4 Given the molecule shown, what tests will be

appropriate for identifying its presence? I. Bromine

Test II. Sodium Bicarbonate Test III. Ceric
Ammonium Nitrate Test. Single choice.
(0/1 Point)
FINALS LAB QUIZ
What testing reagents were employed in
simulation 1 that needed a spatula for transfer? I.
Sodium Bicarbonate II. Ceric Ammonium Nitrate III.
Bromine Solution. Single choice.
(1/1 Point)
I & II
I & III I & II
I only II & III
II only I, II, III
II & III I only
Correct answers: I only II & III
Correct answers: II & III
2
5 The sodium bicarbonate test is used for detecting
the presence of:. Single choice.
(1/1 Point)
carboxylic acids
phenols
aromatic compunds
alkenes
Correct answers: carboxylic acids
Given the molecule shown, what test will be
appropriate for identifying its presence? Single 6 How will you determine a positive result with the
choice. sodium bicarbonate test?. Single choice.
(1/1 Point) (1/1 Point)
Ceric Ammonium Nitrate Test Formation of a turbid or cloudy solution
Sodium Bicarbonate Test Disappearance of reddish brown color of the
None of the above (NOTA) reagent
Bromine Test Formation of red color
Correct answers: Sodium Bicarbonate Test Effervescence
Correct answers: Effervescence
3 The bromine test is used for detecting the
presence of:. Single choice. 7 What testing reagents were employed in
(1/1 Point) simulation 1 that needed a pipette for transfer? I.
alcohols and phenols Sodium Bicarbonate II. Ceric Ammonium Nitrate III.
unsaturated compounds Bromine Solution. Single choice.
two of the choices (1/1 Point)
carboxylic acids I & II
Correct answers: unsaturated compounds I only
II only
 I & III pump inhibitors undergo chemical activation to
II & III sulfonamides which bind to H+/K+ ATPase in
Correct answers: II & III parietal cellsSingle choice.
(1/1 Point)
8 How will you determine a positive result with the I, II, III
ceric ammonium nitrate test?. Single choice. II, III
(1/1 Point) II
Formation of a turbid or cloudy solution I, II
Formation of red color I
Effervescence Correct answers: I
Disappearance of reddish brown color of the
reagent 2
Correct answers: Formation of red color Which of the following statements is true regarding
the molecule below? Single choice.
9 The ceric ammonium nitrate test is used for (1/1 Point)
detecting the presence of:. Single choice.
(1/1 Point)
aromatic compunds
alkenes
carboxylic acids
phenols The ester group contributes to half-life
Correct answers: phenols prolongation.
The chain must be composed of 7-8 atoms for it
10 How will you determine a positive result with to exert biological activity
the bromine test?. Single choice. As seen in its structure, the trimethyl
(1/1 Point) ammonium group is necessary for activity because
Disappearance of reddish brown color of the it is necessary for receptor binding.
reagent It is used in symptomatic treatment of
Formation of red color bradycardia/heart block.
Effervescence Correct answers: As seen in its structure, the
trimethyl ammonium group is necessary for activity
Formation of a turbid or cloudy solution
because it is necessary for receptor binding.

3
A given drug was shown to increase catecholamine
release from adrenergic neurons. The central
nucleus in this drug is more or less: Single choice.
(0/1 Point)
Imidazoline
FINALS QUIZ 1 Phenylisopropylamine
Beta-phenylethylamine
Which of the following statement(s) is(are) true Aryloxypropanolamine
regarding bioprecursor drugs? I. Antivirals are Your answer to question 3 is wrong. Correct
nucleoside analogs that undergo phosphorylation answers: Phenylisopropylamine
as a mechanism of activation II. Mechanisms of
activation involve redox & hydrolysis III. Proton 4
Which of the following is an arylimadazoline? II, III
Single choice. I, II
(1/1 Point)
I, III
Clonidine Your answer to question 6 is wrong. Correct
Phenylephrine answers: I, III
Methamphetamine
Antazoline 7
Tyramine Which of the following agents has/have a beta
Correct answers: Clonidine phenylethylamine structure with the phenyl moiety
containing an ortho-dihydroxy substitution? I.
5 Epinephrine II. Ephedrine III. Dopamine Single
If the meta-position of the benzene ring is the only choice.
region hydroxylated, instead of the traditional (0/1 Point)
meta and para hydroxylations, what happens to II, III
the activity of the drug? Single choice. I
(1/1 Point) I, III
II
I, II, III
Your answer to question 7 is wrong. Correct
answers: I, III

8
The drug becomes a vasoconstrictor. Which of the following statement(s) is(are) true?
The drug becomes a vasodilator. I. The amine group must be tertiary for
The drug becomes a diuretic. optimum activity.
II. Substitution in the para position is
The drug becomes an antihypertensive agent.
essential for selective beta-1
The drug becomes an inotrope.
antagonistic activity.
Correct answers: The drug becomes a
III. Substituents on the amino group must
vasoconstrictor.
be bulky.Single choice.
(1/1 Point)
6
Given the reaction, evaluate which of the following
statement is correct. I. The drug is Nitroglycerin.
The reaction depicted is a mechanism of its
activation. II. The drug is Nitroglycerin. The reaction
depicted shows its mechanism of termination. III.
The enzyme that catalyzes this reaction is
glutathione-S-transferase.Single choice.
(0/1 Point) I, II, III
II, III
III
I
I, II
Correct answers: II, III
I
I, II, III 9
What are the reactions involved seen in the image? Ethyl
I. Oxidative Deamination to an Aldehyde II. Propyl
Oxidative N-demethylation III. Oxidation of an
Ethanol
Aldehyde to Carboxylic Acid IV. Conjugation with
Glutathione V. Conjugation with Glutamine. Single Ether
choice. Correct answers: Ethyl
(0/1 Point)
12
Given the reaction, evaluate which of the following
statement is correct.Single choice.
(1/1 Point)
I, III, V
I, IV
I, III, IV
I, V
I, II, III
Your answer to question 9 is wrong. Correct
answers: I, III, V The drug is Isoniazid, metabolized by Glutamine
conjugation. The drug therefore becomes non-
10 toxic.
Which of the following statement(s) about
The drug is Isoniazid, metabolized by N-
pheniramines is(are) true?
acetyltransferase. The metabolite causes
I. Some contain a diphenyl group, some
hepatotoxicity especially in Asian patients.
have phenyl and pyridyl groups.
II. Dextrorotatory isomers are The drug is Hydralazine, metabolized by N-
pharmacologically active. acetyltransferase. The drug is therefore
III. All are employed as systemic drugs inactivated.
administered via PO. The drug is Isoniazid, metabolized by N-
IV. They are the most active H1 acetyltransferase. The drug therefore loses its anti-
antagonists.Single choice. tubercular effect and the dose should be increased.
(1/1 Point) The drug is Isoniazid, metabolized by N-
II, III acetyltransferase. The metabolite is more potent.
I, II Correct answers: The drug is Isoniazid, metabolized
by N-acetyltransferase. The metabolite causes
I, IV
hepatotoxicity especially in Asian patients.
II, IV
III, IV 13
Correct answers: II, IV What is the drug molecule in the reaction and what
is its description?Single choice.
11 (1/1 Point)
The moeity between X and N is usually: Single
choice.
(1/1 Point)
Two of the choices
Procainamide, an amide anti-arrhythmic
Mescaline, an arylacetic acid hallucinogen
Lidocaine, an amide local anesthetic
Hydrocarbon Mescaline, an alkaloidal amine hallucinogen
Correct answers: Mescaline, an alkaloidal amine 17
hallucinogen Ampicillin is formulated to Hetacillin by making the
drug react with:Single choice.
14 (1/1 Point)
A patient with primary open-angle glaucoma was Formaldehyde
prescribed with topical Epinephrine for application Amide
onto the eye. You know very well that Epinephrine
Nucleoside Analogs
penetrates the mucus membranes of the eye
poorly. Which of the following agents will you Acetone
suggest as an alternative? Single choice. Acetaldehyde
(1/1 Point) Correct answers: Acetone
Fenoldopam
18
Physostigmine
If the meta-position of the benzene ring is the only
Dipivefrin region hydroxylated, instead of the traditional
Pilocarpine meta and para hydroxylations, what happens to
Norepinephrine the oral bioavailability of the drug? Single choice.
Correct answers: Dipivefrin (1/1 Point)

15
Co-substrate(s) that terminate or attenuate
pharmacologic activity includes: I. Acetyl-CoA II.
UDP-Glucuronic Acid III. Phosphoadenosine
phosphosulfate Single choice.
(1/1 Point)
Increased due to decreased attack by COMT
I, II
Decreased due to increased attack by COMT
I, II, III
Two of the Choices
III
Decreased due to increased attack by MAO
II
Increased due to decreased attack by MAO
I Correct answers: Increased due to decreased attack
Correct answers: I by COMT

16 19
An example of a drug molecule that possesses A patient being maintained on Levocarbidopa for
similarity with the structure depicted is:Single Parkinsonism will more or less benefit from the co-
choice. administration of an antihistamine that belongs to
(1/1 Point) which of the following chemical class? Single
choice.
(1/1 Point)
Alkylamines
Terfenadine Piperazines
Hydroxyzine Ethanolamines
Omeprazole Piperidines
Clemastine Phenothiazines
Ranitidine Correct answers: Ethanolamines
Correct answers: Ranitidine
20
What are the enzymes involved in the reaction? I. Phenacetin was removed from the market due to
CYP II. Glutamine-N-acyltransferase III. its toxic metabolite that can cause hepatotoxicity
Glutathione-S-transferase IV. Aldehyde and nephrotoxicity which is formed via what
Dehydrogenase V. Alcohol DehydrogenaseSingle reaction? Single choice.
choice. (1/1 Point)
(0/1 Point) Glycine Conjugation
Glucuronidation
Sulfate Conjugation
O-deethylation
I, III, IV
Methylation
I, II, IV
Correct answers: Sulfate Conjugation
II, IV
I, II, V 24
I, III, V A new drug was found to have low oral absorption
Your answer to question 20 is wrong. Correct and bioavailability. The new drug does not fit the
answers: I, II, IV criteria for ester prodrug formulation and it was
decided that it should be formulated as a Mannich
21 Base. Which of the following functional groups
A drug used as an adjunct for ulcer due to its ability does this drug possibly contain?
to increase PG synthesis in the gastric mucosa: I. Alcohols
Single choice. II. Amines
(1/1 Point) III. Carbonyl Compounds Single choice.
Rebamipide (0/1 Point)
Sucralfate II, III
Hyoscine-N-butylbromide I
Misoprostol I, II, III
Amoxicillin II
Correct answers: Rebamipide I, II
Your answer to question 24 is wrong. Correct
22 answers: I, II
The two Ar's in the structure shown is linked in
what group of drugs?Single choice. 25
(1/1 Point) Methenamine is a urinary tract antiseptic & its
active metabolite is ____________. Single choice.
(1/1 Point)
Carboxylic Acid
Methanol
Acetaldehyde
Piperazines
Ethanol
Ethanolamines
Formaldehyde
Ethylenediamines Correct answers: Formaldehyde
Phenothiazines
Alkylamines 26
Correct answers: Phenothiazines Given the reaction, which of the following
statement(s) is(are) true?
23
 I. The reaction is the most dominant
functionalization reaction.
II. The reaction is the most dominant non-
functionalization reaction.
III. An endogenous molecule is involved in Acetyl CoA
the reaction.Single choice. Sulfate and ATP
(1/1 Point) Methionine and ATP
Glucose and UTP
CoA and ATP
Correct answers: CoA and ATP
I, II, III
29
II, III
The N in the structure is usually a part of a
II hetercycle in what group of drugs?Single choice.
I, II (1/1 Point)
I, III
Correct answers: II, III

27
Which of the following properties may be expected
from drugs possessing this general structure? I. Pheniramines
Inhibition of allergic response II. Anticholinergic Ethylenediamines
Activity III. Inhibition of gastric acid secretionSingle
Piperazines
choice.
(0/1 Point) Phenothiazines
Tertiary Amino Alkyl Ethers
Correct answers: Piperazines

30
For patients who are suffering from ophthalmic
I conjunctivitis and have allergic histories to
III ethanolamines, piperazines, phenothiazines and
alkylamines, which of the following agents will be
II, III
considered the most appropriate? Single choice.
I, II, III
(1/1 Point)
I, II
Naphazoline
Your answer to question 27 is wrong. Correct
Tetrahydrozoline
answers: I, II
Antazoline
28 Pyrilamine
Which of the following biomolecules are involved Tripelennamine
in the reaction? Correct answers: Antazoline
I. CoA and ATP
II. Acetyl CoA 31
III. Glucose and UTP Which of the following biomolecules are involved
IV. Methionine and ATP in the following reaction? I. CoA and ATP II. Acetyl
V. Sulfate and ATP CoA III. Glucose and UTP IV. Methionine and ATP V.
Single choice. Sulfate and ATPSingle choice.
(1/1 Point)
(1/1 Point) 34
Doxylamine & Carbinoxamine belong to what
chemical class of antihistamines?Single choice.
(1/1 Point)
Ethanolamines
I Piperidines
I & IV Piperazines
IV & V Alkylamines
V Phenothiazines
IV Correct answers: Ethanolamines
Correct answers: V
35
32 Considering the structure, which of the following
Antibiotics for H. pylori-induced ulcer, statement/s is/are true?
except:Single choice. I. Maximal activity of this drug molecule is
(0/1 Point) seen when the meta & para positions of
Clarithromycine the ring have hydroxyl groups.
Doxycycline II. Substitution of the catechol ring with a
resorcinol ring offers beta-1 selective
Amoxicillin
agonist activity.
Tetracycline III. Bulky substituents confer beta-2
Metronidazole selectivity.Single choice.
Your answer to question 32 is wrong. Correct (0/1 Point)
answers: Doxycycline I, II, III
I
33
I, II
I, III
III
Your answer to question 35 is wrong. Correct
answers: I, III

Which of the following would you consider as a
necessity or “a must” for a drug to have
antimuscarinic activity? Single choice.
(1/1 Point)
X being an ethylene functional group.
R1 & R2 being aromatic.
N substituent being quaternary ammonium.
X being an amine
The amine must be 2 carbon atoms away from
the tri-substituted carbon atom.
Correct answers: N substituent being quaternary
ammonium.
36
Given the molecule, which of the following is/are
true?
I Presence of β hydroxyl groups decreases
effectivity while, α methyl groups increases
effectivity.
II N-substituents make them less active, &
substituents larger than methyl groups, render
them inactive. III. The primary amine is subject to
alteration into secondary or tertiary amine in order
to increase activity. Single choice.
(0/1 Point)
 The drug is a selective alpha-1 agonist for
hypotension.
The drug is a non-selective beta-blocker used
for hypertension and hyperventilation.
Your answer to question 38 is wrong. Correct
answers: The drug is a selective beta-2 agonist for
premature labor.

I, III 39
I, II
II, III
I, II, III
I
Your answer to question 36 is wrong. Correct
answers: I, II

37
These are types of prodrugs that don’t have pro- Given the structure below, which of the following
moeities & rely on biotransformation for their statement(s) is(are) true?
activation.Single choice. I. In order for the drug to inhibit the
(1/1 Point) allergic response, the alkyl bridge
Esters maybe composed of 2 carbon atoms.
Bioprecursor Drugs II. In order for the drug to exhibit an
Carrier-Linked Prodrugs antipsychotic effect, the alkyl bridge
Mannich Bases must be composed of 3 carbon atoms.
III. For the drug to be useful as an
Carbonyl Carbons
antipsychotic, the heterocyclic ring must
Correct answers: Bioprecursor Drugs
be substituted.Single choice.
(1/1 Point)
38
Question II
Single choice. I, III
(0/1 Point) I, II, III
I, II
II, III
Correct answers: I, II, III

The drug is a selective beta-2 agonist for
management of acute asthma.
The drug is a selective beta-1 agonist used for
heart failure.
The drug is a selective beta-2 agonist for
premature labor.
40
Which of the following statement(s) is(are) true? I.
The presence of four carbons in the chain
separating the ring & nitrogen group is necessary
for optimal antagonistic activity. II. Maximal
antagonistic activity requires that the terminal
nitrogen group should be polar & non- basic. III.
The imidazole ring is required for competitive
inhibition at H2 Receptors and hence, should not
be replaced. Single choice.
(1/1 Point)
 (0/1 Point)
Clonidine
Isoproterenol
Methamphetamine
I, II, III
Salbutamol
III
Phenylephrine
I, II
Your answer to question 43 is wrong. Correct
I
answers: Methamphetamine
II, III
Correct answers: I, II 44
41 Which of the following is the co-substrate involved
Which H2 blocker has greater than 90% in the reaction? Single choice.
bioavailability?Single choice. (1/1 Point)
(1/1 Point)
Cimetidine
Terfenadine
Nizatidine S-adenosylmethionine
Ranitidine Coenzyme A and ATP
Correct answers: Nizatidine Acetyl CoA
UDP-glucuronic Acid
42 Phosphoadenosine phosphosulfate
If an isopropyl group or a tert-butyl group is Correct answers: S-adenosylmethionine
attached to the nitrogen atom: Single choice.
(1/1 Point) 45
Given the reaction, which of the following is true? I.
The reaction is a phase I reaction. II. The reaction is
O-demethylation. III. The reaction is a phase II
reaction. IV. The reaction involves phenol
methylation. V. The reaction involves catechol
methylation. Single choice.
(1/1 Point)
Two of the choices
The drug’s absorption and bioavailability will be
increased due to decreased degradation by COMT.
The drug’s absorption and bioavailability will be I&V
decreased due to increased water solubility. III & IV
The drug’s absorption and bioavailability will be I & IV
increased due to decreased degradation by MAO.
III & V
The drug will become a selective alpha-2
I & II
agonist.
Correct answers: III & V
Correct answers: The drug’s absorption and
bioavailability will be increased due to decreased
46
degradation by MAO.
Given the structure of Bethanechol, which of the
following is true?:Single choice.
43
(1/1 Point)
Which of the following is a phenylisopropylamine?
Single choice.
 The methyl group on the carbon beta to the II
onium group confers affinity to nicotinic receptors. I
The amine group of the urethane group renders Correct answers: II, III
it stable against attack by ACh esterases due to pi
electron delocalization. 49
The carbonyl moiety becomes sensitive to Esters of which of the following functional groups
attachment by serine present in ACh esterase due are for enhancing water-solubility? I. Succinates II.
to the urethane amino group. Sulfonates III. PalimitatesSingle choice.
The ionized quaternary nitrogen is a (1/1 Point)
pharmacophore at nicotinic receptors. II, III
Correct answers: The amine group of the urethane I, II, III
group renders it stable against attack by ACh I, II
esterases due to pi electron delocalization. I
III
47
Correct answers: I, II
Given the reaction, which of the following
statements is/are true? I. The reaction is a
50
conjugative reaction. II. The general substrate for
If a methyl group is attached to the alpha-carbon,
such reactions involves aromatic acids. III. The
what is the most probable effect that can be
reaction enhances water-solubility of susceptible
observed from this drug molecule?Single choice.
substrates. Single choice.
(1/1 Point)
(1/1 Point)

I, II, III
II, III Inotropism
I Bronchodilation
I, III Increased lipolyisis
I, II Hypotension
Correct answers: I, II, III Hypertension due to inotropism
Correct answers: Hypotension
48
Which of the following statement(s) regarding 51
Estramustine is(are) true? Given the reaction, what enzyme is involved?Single
I. The steroidal nucleus is an alkylating choice.
agent required for the antineoplastic (1/1 Point)
effect.
II. The normustard group is required for
the antineoplastic effect.
III. The drug is used for prostate cancer. CYP
Single choice. O-acetyltransferase
(1/1 Point) Alcohol-O-methyltransferase
I, II Phenol-O-methyltransferase
I, II, III Catechol-O-methyltransferase
II, III Correct answers: Catechol-O-methyltransferase
 Tripelennamine
52 Pheniramine
A patient with Peptic Ulcer Disease, was prescribed Correct answers: Promethazine
a drug to be maintained for 2 months in order to
assure complete healing of his ulcer wound. After 6 55
weeks of therapy, he complains of impotence and Which of the following agents is an alkylamine, in
some signs of breast tenderness. This patient was which the connecting atom for the aromatic
probably maintained on which of the following moieties is linked by an sp2-hybridized carbon
agents? Single choice. atom? Single choice.
(1/1 Point) (1/1 Point)
Cimetidine Pheniramine
Misoprostol Dimethindene
Pantoprazole Promethazine
Pirenzepine Chlorphenamine
Sucralfate Azelastine
Correct answers: Cimetidine Correct answers: Dimethindene
56
53
If the amino group was converted to a secondary What is the clinical use of Bethanechol? Single
amine via attachment of an isopropyl group, what choice.
is expected from its effect? Single choice. (1/1 Point)
(0/1 Point)
Tachycardia
Intestinal Onstruction
Urinary Retention
Glaucoma
CHF
Correct answers: Urinary Retention
The drug will be selective for exerting an
inotropic effect. 57
Which of the following statements will definitely
The drug will be selective for exerting a
increase the oral absorption and bioavailability of
bronchodilating effect.
the beta-phenylethylamines? Single choice.
The drug will be selective for exerting a (1/1 Point)
vasoconstricting effect.
Attachment of a hydroxyl group at position 3
The drug will be a powerful laxative.
Attachment of a tert-butyl group to the
Your answer to question 53 is wrong. Correct
nitrogen atom
answers: The drug will be selective for exerting a
bronchodilating effect. Attachment of 3 more alkyl groups to the
nitrogen atom
54 Attachment of a hydroxyl group at the beta
Which of the following antihistamines favor a carbon
branching structure in its alkyl chain?Single choice. Attachment of a hydroxyl group and
(1/1 Point) hydroxymethyl groups at positions 4 and 3
Promethazine respectively.
Diphenhydramine Correct answers: Attachment of a hydroxyl group
and hydroxymethyl groups at positions 4 and 3
Cyclizine
respectively.
58
A patient suffering from the common cold will most
likely benefit from the administration of an
antihistamine that belongs to which of the
following class? Single choice.
(1/1 Point)
Piperazines
Phenothiazines
Ethanolamines
Ethylenediamines Which of the following statement/s is/are true
Alkylamines regarding the drug molecule represented below?
Correct answers: Alkylamines I. The drug is currently more used for
seizures.
59 II. The drug molecule is more toxic than
Which of the following statement(s) regarding Benzodiazepines.
promoeities is(are) true? III. III. The drug molecule’s activity is
I. Promoeities must be devoid of increased if the substituents at position
pharmacological activity. 5 are alkyl groups instead of hydrogen
II. Promoeities need not have atoms.Single choice.
pharmacological activity. (1/1 Point)
III. Promoeities may also have I, II, III
pharmacological activity.Single choice. I, II
(1/1 Point)
II, III
I, II, III
I, III
II, III
III
I, II Correct answers: I, II, III
I
II 2
Correct answers: II, III

60
Which of the following substrates will be activated
prior to conjugative reactions? Single choice.
(0/1 Point)
Benzoic Acids
Phenols
Catechols
Amines
Resorcinols
Correct answer: Benzoic acids
With regards to positions 6, 8, and 9 of the drug
molecule, which of the following statement/s
FINALS QUIZ 2 is/are true?Single choice.
1 (1/1 Point)
 Substitution with alkyl groups at these positions
increases the drug molecule’s effects
Substitution of these positions with hydroxyl
groups increase the drug’s effects
Leaving them un-substituted increases drug’s
effects
Incorporating large alkyl groups enhance
lipophilicity and therefore increase the drug’s
effects
Correct answers: Leaving them un-substituted
increases drug’s effects

3 Which of the following statement/s regarding the

Which of the following agents is an opioid analgesic position 1 of the drug molecule is/are true?Single
not commonly used as an aqueous pre-anesthetic? choice.
Single choice. (1/1 Point)
(1/1 Point) Activity is enhanced if this position is
Meperidine substituted with small alkyl groups such as methyl.
Methadone Activity is decreased if this position is
Morphine substituted with small alkyl groups such as methyl.
Fentanyl Activity is enhanced but half-life is shortened if
this position is substituted with a hydroxyl group.
Remifentanil
Correct answers: Methadone Hydrolytic cleavage of the bond between
position 1 and 2 will enhance the drug’s activity.
4 Leaving this position un-substituted increases
Which of the following statement/s correctly the drug’s activity.
describes the properties of the local anesthetics? I. Correct answers: Activity is enhanced if this
The lipophilic center of these drugs is essential for position is substituted with small alkyl groups such
blocking sodium channels of neurons. II. The as methyl.
hydrophilic center of these drugs is essential for
penetrating the axon of neurons. III. These group of 6
drugs can be esters or amides and the amides are With regards to the structure of Phenothiazine
usually longer acting.Single choice. anti-psychotics, which of the following conditions
(1/1 Point) will definitely increase their potency?Single choice.
III (1/1 Point)
I, II, III Substituting the N10 position with a propyl
dialkyl amino side chain
I, II
Substituting the N10 position with a propyl
II, III
piperazine side chain
I, III
Substituting the N10 position with a propyl
Correct answers: III
piperidine side chain
5 Converting the nitrogen atom at position 10
into a carbon atom
Correct answers: Substituting the N10 position with
a propyl piperazine side chain

7
Amongst the drugs for ADHD, which of the The addiction liabilities of the drug molecule
following agents is considered to be the most increases.
potent?Single choice. The efficacy of the drug molecule increases with
(1/1 Point) no appreciable effects on toxicity and abuse
Threo-Methylphenidate potential.
Erythro-Methylphenidate Correct answers: The efficacy of the drug molecule
levo-Threo-Methylphenidate increases with no appreciable effects on toxicity
Lisdexamfetamine and abuse potential.
dextro-Threo-Methylphenidate
10
Correct answers: dextro-Threo-Methylphenidate
Which of the following anti-seizure drugs are
sodium channel blockers? I. CBZ II. Phenytoin III.
8
Phenobarbital. Single choice.
Which of the following agents is expected to have
(1/1 Point)
the greatest potency?Single choice.
(1/1 Point) I, II, III
Trifluoperazine I, II
Pipracetazine II, III
Levomepromazine I, III
Trifluopromazine III
Correct answers: I, II
Thioridazine
Correct answers: Trifluoperazine
11
Which of the following agents will more or less
9
closely resembles the structure and activity of
Haloperidol? I. Clopentixol II. Penfluridol III.
ThiothixeneSingle choice.
(1/1 Point)
II
I, II, III
I, II
II, III
I, III
Correct answers: II

12
Which of the following agents is expected to cause
Given the molecule, which of the following less CNS depression and less addiction liabilities?
statement/s is/are true regarding substitution of Single choice.
the drug molecule with a phenyl position at (1/1 Point)
position 5?Single choice. Phenobarbital
(1/1 Point) Buspirone
The tendencies of the drug to induce Diazepam
respiratory depression is increased.
Zolpidem
The CNS depressant effects of the molecule is
Zaleplon
intensified and becomes toxic.
Correct answers: Buspirone
13 Which of the following can decrease this drug
molecule's activity? I. Alkyl substitution at position
3 II. Hydroxy substitution at position 3 III.
Conversion of N at position 1 to CSingle choice.
(1/1 Point)
I, II, III
I, III
II, III
I, II
II
Correct answers: I, III

15
Which of the following drugs closely resembles the
Given the molecule, If an electronegative action of the Benzodiazepines?Single choice.
substituent is attached to position 7, which of the (1/1 Point)
following is expected from its activity?Single Zolpidem
choice. Diphenhydramine
(1/1 Point) Buspirone
The tendencies of the drug to induce Ramelteon
respiratory depression is increased. Chloral Hydrate
The CNS depressant effects of the molecule is Correct answers: Zolpidem
intensified and becomes toxic.
The addiction liabilities of the drug molecule 16
increases. Which of the following anti-seizure agents will
The efficacy of the drug molecule increases with more or less have lower alkyl groups in their ureide
no appreciable effects on toxicity and abuse structure?Single choice.
potential. (1/1 Point)
Correct answers: The efficacy of the drug molecule Phenytoin
increases with no appreciable effects on toxicity CBZ
and abuse potential. VPA
Oxazolidinedione
14
Ethosuximide
Correct answers: Ethosuximide

17
Which of the following chemicals will more or less
be the most effective bronchodilator?Single choice.
(0/1 Point)
1,3,7-trimethylxanthine
3,7-dimethylxanthine
1,3-dimethylxanthine
Two of the choices
Your answer to question 17 is wrong. Correct
answers: 1,3-dimethylxanthine
18
Which of the following chemicals produced the
only atypical anti-psychotic with partial 5-HT and
dopamine agonistic properties?Single choice.
(1/1 Point)
Benzamides
Fluorophenylindoles
Benzisoxazoles
Dibenzodiazepine
Dihydrocarbostyrol
Correct answers: Dihydrocarbostyrol

19
Which of the following agents may induce
schizophrenic-like symptoms due to NMDA
blockade? I. Ketamine II. Etomidate III.
PhencyclidineSingle choice.
(1/1 Point)
I & III only
II & III
III only
I, II & III
I & II
Correct answers: I & III only

20
Which of the following agents is classified as an
Ester of PABA?Single choice.
(1/1 Point)
Cocaine
Dibucaine
Cyclomethicaine
Propoxycaine
Dibucaine