Professional Documents
Culture Documents
13
Reactions and Preparations of Ethers and Epoxides
1. Predict the major products (if any) of the reaction of isobutyl-n-propyl ether with:
a. conc. NaOH NO REACTION
b. H2Cr2O7, room temp. NO REACTION
c. dilute aq. H2SO4 Isobutanol & Propanol
d. hot conc. HBr Isobutanol & 1-iodopropane
O Br OH
c.
+ HBr
2-bromocyclohexanol
CH3-CH-CH-CH3 + C6H5COOH
d. CH3CH=CCH3 + C6H5COOOH
O
2,3-epoxy-butane + benzoic acid
e.
OH
O + CH3MgBr
CH3
2-methylcyclohexanol
3. Write the major products of the reaction of ethylene oxide with each of the following:
a. HI
CH2 - CH2 + HI CH2 - CH2
O I OH
Ethylene iodohydrin / 2-iodoethanol
b. aq. KOH
CH2 - CH2
CH2 - CH2
c. H2SO4 in CH3CH2CH2OH as solvent
CH3CH2CH2OH CH3CH2CH2O OH
CH2 - CH2
2-propoxyethanol
O H2SO4
d. CH3CH2CH2CH2MgBr
CH3CH2CH2CH2CH2CH2OH
CH2 - CH2 + CH3CH2CH2CH2MgBr hexanol
O
e. CH3CH2NH2
4. Starting with an appropriate alcohol, outline the method of synthesis of each of the
following:
a. CH3-O-CHCH3
CH3
CH3 CH Br
CH3
b. C6H5OCH2CH3
OH O- Na+ O-CH2CH3
Na CH2CH3Br
+ NaBr
c. (CH3CH2CH2CH2)2O
CH3CH2CH=CH2
180 Co
CH3CH2CH2CH2OH
CH3CH2CH2CH2-O-CH2CH2CH2CH3
140 oC