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combination synergically suppressed TGF-β1-induced expression of α-SMA (right). Western

blot analysis of α-SMA and PAI-1 were performed with lysates of LX-2 cells that had been

pretreated with 400 nM verteporfin and/or 100 μM LQ for 1 h being followed by exposure to

TGF-β1 (5 ng/ml) for 24 h.

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Fig. 7. (A) Western blot analyses were assessed with homogenates of liver tissues in mice

treated with vehicle, CCl4, CCl4 + LQ 10 mg/kg, and CCl4 + LQ 30 mg/kg groups. (B)
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Schematic diagram showed that LQ regulated of Hippo/Yap and TGF-β1/Smad signaling

pathway ameliorating liver fibrosis and hepatic stellate cell activation.

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