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Molecular Basis of Inheritance

d. 200
1. Φ x 174 bacteriophage has 9. Packaging of chromatin t higher level to form
chromosomes is carried out by
a. 48502 bp
a. Polyamines
b. 48502 nucleotides
b. Histone tails
c. 5386 bp
c. Nonhistone chromosomal proteins
d. 5386 nucleotides
d. Lamins
2. Number of nucleotides pairs in the genome of
Escherichia coli is 10. The two strands of DNA are held together by
a. 4.6 X 106 a. Phosphodiester bonds
b. 4.6 X 107 b. Glycosidic bonds
c. 4.6 X 108 c. Hydrogen bonds
d. 4.6 X 109 d. S –S bonds
3. 3’ end of polynucleotides contains 11. Nucleic acids are made of
a. OH of 3’C a. Nucleotides
b. H- of 2’C b. Nitrogen bases
c. OH-of 5’ C c. Nucleosides
d. OH at 4’C d. Amino acids
4. 5-methyl uracil is 12. Hydrogen bonds between cytosine and guanine
are
a. Adenine
a. 1
b. Guanine
b. 2
c. Thymine
c. 3
d. Cytosine
d. 4
5. Who provided X-ray diffraction data of DNA
to Watson and Crick? 13. Who proposed the central dogma?
a. Chargaff a. Watson and Crick
b. Wilkins b. Beadle and Tatum
c. Franklin c. Klug
d. Both Wilkins and Franklin d. Crick
6. The total length of human DNA is 14. RNA contain sugar
a. 22 m a. Hexose
b. 2.2 m b. Ribose
c. 6.5 m c. Fructose
d. 1.8 m d. Glucose
7. “Beads on string” structure is seen under 15. In a DNA molecule cytosine is 18%.
electron microscope for Percentage of adenine would be
a. Euchromatin a. 32%
b. Heterochromatin b. 64%
c. Nucleosomes in chromatin c. 36%
d. Ribosomes in polysome d. 18%
8. Number of pairs of DNA double helix 16. Watson and Crick shared the Nobel prize for
associated with a nucleosome is DNA structure with
a. 8 a. Franklin
b. 100 b. Wilkins
c. 125 c. Monod
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d. Pauling
17. In DNA adenine is 30% what would be the 25. In some viruses, the flow of information is in
percentage of guanine reverse direction , i.e. from RNA to DNA. Can
a. 10 % you suggest a simple name to the process?
b. 20% a. Transcription
c. 30% b. Transception
d. 40% c. Reverse transcription
18. In DNA, how far is each base pair from the d. Translation
next base pair 26. Positively charged basic proteins that are found
a. 34 nm in eukaryotes are called
b. 3.4 nm a. Histones
c. 0.34 nm b. Protamine
d. 2.0 nm c. Arginine
19. Haploid content of human DNA is d. Lysine
a. 1.65 X 109 bp 27. Linker-DNA is attached to
b. 3.3 X 109 bp a. H1
c. 4.6 X 10 9 bp b. H2A
d. 0.3 X 109 bp c. H2B
20. Nucleoside is formed when the nitrogenous d. H3
bases are linked to 28. The association of histone H1 with a
a. Sugar nucleosome indicates
b. Phosphate a. Transcription is occurring
c. Proteins b. DNA replication is occurring
d. Fats c. The DNA is considered into chromatin
21. What is the difference between adenosine and fibre
deoxyadenosine? d. The DNA double helix is exposed
a. Only sugar 29. Lightly stained part of chromatin which
b. Only purine remains loosely packed and is transcriptionally
c. Only phosphate active named as
d. All of these a. Euchromatin
22. Which of the following are all nucleotides? b. Heterochromatin
a. Adenosine, cytidilic acid, cytosine c. Chromatosome
b. Adenylic acid, cytidilic acid, guanylic d. Chromonemata
acid 30. Part of chromatin which is densely packed,
c. Cytidine, adenine, adenylic acid stain darkly and is transcriptionally inactive is
called
d. Uracil, thymidine, thymidylic acid
a. Euchromatin
23. X-ray data diffraction of DNA was produced
by b. Chromatosome
a. Watson and Crick c. Heterochromatin
b. Wilkins and Franklin d. Chromosome
c. Bateson and Punnett
d. Both a and b
24. In DNA 20% bases are adenine. What
percentage of bases are pyrimidines?
a. 30%
b. 60%
c. 50%
d. 20%

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ANSWERS KEY

1. D
2. A
3. A
4. C
5. D
6. B
7. C
8. D
9. C
10. C
11. A
12. C
13. D
14. B
15. A
16. B
17. B
18. C
19. B
20. A
21. A
22. B
23. B
24. C
25. C
26. A
27. A
28. C
29. A
30. C

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