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PROPOR SG-Rev 3A
PROPOR SG-Rev 3A
• liquid filters
• polyethersulphone
Note: PROPOR and DEMICAP are registered trademarks of Parker domnick hunter
Performance Characteristics
Flow (gpm (US)) Flow (gpm (US)) Flow (gpm (US))
0 0.5 1.0 1.5 2.0 2.5 0 2 4 6 8 0 0.5 1.0 1.5 2.0 2.5
300 250 600
B Size 4 2.5 8
Differential Pressure (mbar)
200 7
2.0
3 6
200 400
A Size
150 1.5 5
B Size
150 300
K Size 2 4
100 1.0
100 200 3
A Size
10¨ (250 mm)
1 2
50 0.5
50 100
1
0 0 0 0 0 0
0 2 4 6 8 10 0 10 20 30 0 2 4 6 8 10
Flow (L / min) for liquid @ 20 °C and 1 cp Flow (L / min) for liquid @ 20 °C and 1 cp Flow (L / min) for liquid @ 20 °C and 1 cp
Cartridge flow rates MURUS flow rates (10¨ Size (250 mm)) DEMICAP flow rates
0.2 µm Cartridge 0.2 µm Capsule 0.2 µm Capsule
PROPOR SG Filter Cartridges
Specifications
Materials of Construction Effective Filtration Area (EFA) Quality Standards
Filtration Membrane: Polyethersulphone 10¨ (250 mm): 0.55 m2 (5.92 ft2) Pharmaceutical grade products are
Upstream Support: Polyester K Size: 0.26 m2 (2.79 ft2) manufactured in accordance with cGMP,
Downstream Support: Polyester A Size: 0.20 m2 (2.15 ft2) 100% flushed with pharmaceutical purified
B Size: 0.10 m2 (1.07 ft2) water and integrity tested prior to despatch.
Filter Cartridges E Size: 0.05 m2 (0.53 ft2) A sample of each lot is tested to demonstrate
Inner Support Core: Polypropylene Syringe ø50 mm: 14.50 cm2 (2.25 in2) conformity to validated claims.
Outer Protection Cage: Polypropylene
End Caps: Nylon Sterilisation Gamma-Irradiation
End Caps Insert: 316L Stainless Steel Autoclave Steam-in-Place PROPOR SG MURUS & DEMICAP disposable
Standard o-rings/gaskets: Silicone Cycles Temp Cycles Temp filters can be gamma-irradiated up to a
(30 min.)
maximum dosage of 40 kGy.
MURUS Disposable Filter Capsules Cartridges 10 130 °C (266 °F) 30 130 °C (266 °F)
MURUS 5 130 °C (266 °F) - -
Core: Polypropylene
DEMICAP 10 130 °C (266 °F) - -
Sleeve: Polypropylene
Syringe 1 130 °C (266 °F) - -
Standard o-rings/gaskets: Silicone
Capsule Body: Polypropylene PROPOR SG filter cartridges can be
Capsules Vent Seals: Silicone sanitised with hot water at up to 90 °C
(194 °F) and are compatible with a wide
DEMICAP Filter Capsules range of chemicals.
Core: Polypropylene
Sleeve: Polypropylene For detailed operational procedures and
End Caps: Nylon advice on cleaning and sterilisation, please
Capsule Body: Nylon contact the Technical Support Group through
Capsules Vent Seals: Silicone your usual Parker domnick hunter contact.
Filling Bell: Polycarbonate
Food and Biological Safety
Syringe Filters Materials conform to the relevant
Body: Polypropylene requirements of 21CFR Part 177 and current
USP Plastics Class VI - 121 °C and
Recommended Operating Conditions ISO10993 equivalents.
Filter Cartridges
Up to 70 °C (158 °F) continuous operating
temperature and higher short-term
temperatures during CIP to the following
limits:
Temperature Max. Forward dP
°C °F (bar) (psi)
20 68 5.0 72.5
40 104 4.0 58.0
60 140 3.0 43.5
80 176 2.0 29.0
90 194 1.7 24.6
Performance Characteristics
TOC / Conductivity Oxidisable Substances Retention Characteristics
The filtrate quality from a 10¨ (250 mm) PROPOR SG filter cartridges meet current PROPOR SG filter cartridges are validated
PROPOR SG conforms to the requirements USP and EP quality standards for sterile by bacterial challenge testing with
of current USP <643> (TOC) and USP <645> purified water for oxidisable substances Brevundimonas diminuta to current ASTM
(conductivity) within the first 200 ml flush of following a <1 litre water flush. F838-05 methodology (107 organisms / cm2
purified water. EFA minimum) with typical in-house
Integrity Test Data challenge levels being 1011 organisms per
Endotoxins All filters are integrity testable to the 10¨ (250 mm) filter cartridge.
Aqueous extracts from the 10¨ (250 mm) following limits when wet with water and
PROPOR SG contain < 0.25 EU / ml when using air as the test gas. 140
tested in accordance with the Limulus HSA
120 g-globulin
Amoebocyte Lysate test. Micron Rating 0.2
(LSG).
Protein binding on membrane materials
350
Differential Pressure @ 10 L / min (mbar)
300
250
200
150
100
50
0
Competitor A Competitor B Competitor A PROPOR SG
Nylon PVDF PES
Membrane Material
Ordering Information
Cartridges
ZCSG - -
Code ǀ Length (Nominal) Code ǀ Micron Code ǀ Endcap (10¨) Code ǀ Variant Code ǀ O-rings1
B 2.5¨ (65 mm) 010 0.10 µm B dh DOE P Pharmaceutical E EPDM2
A 5¨ (125 mm) 020 0.20 µm C BF / 226 Bayonet S Silicone
K 5¨ (125 mm) 045 0.45 µm G Recess / 222 V Viton
1 10¨ (250 mm) R BF / 222 Bayonet 1
Silicone o-ring supplied
2 20¨ (500 mm) as standard without
3 30¨ (750 mm) having to specify the
SK Retrofit
T TRUESEAL
Y Demi Stub
Z Demi A & B Std
MURUS Capsules
ZLSG - - -
Code ǀ Length (Nominal) Code ǀ Micron Code ǀ Inlet Connection Code ǀ Outlet Connection Code ǀ Variant Code ǀ Grade Code ǀ Design Code ǀ O-rings1
K 5¨ (125 mm) 010 0.10 µm A / ¨ Tri-Clamp
3 4
A / ¨ Tri-Clamp
3 4
P Pharmaceutical N Non-sterile L In-Line E EPDM2
1 10¨ (250 mm) 020 0.20 µm B 11/2¨ Tri-Clamp B 11/2¨ Tri-Clamp S Pre-sterilised T T-Port S Silicone
2 20¨ (500 mm) 045 0.45 µm D 1¨ Hosebarb D 1¨ Hosebarb γ (>25 kGy) V Viton
3 30¨ (750 mm) T 1¨ Tri-Clamp T 1¨ Tri-Clamp 1
Silicone o-ring supplied
as standard without
having to specify the
‘S’ code
2
EPDM - Ethylene
Propylene Diene
Monomer Rubber
DEMICAP Capsules
ZESG - - -
Code ǀ Length (Nominal) Code ǀ Micron Code ǀ Inlet Connection Code ǀ Outlet Connection Code ǀ Variant Code ǀ Grade Code ǀ Pack N° Code ǀ Accessory
E 4.4¨ (113 mm) 010 0.10 µm T 1¨ Tri-Clamp T 1¨ Tri-Clamp P Pharmaceutical N Non-sterile 3 Pack of 3 FB Filling Bell
B 5.5¨ (140 mm) 020 0.20 µm N 1
/2¨ NPT Male N 1
/2¨ NPT Male S Pre-sterilised
A 7.9¨ (200 mm) 045 0.45 µm H 1
/2¨ Hosebarb H 1
/2¨ Hosebarb γ (>25 kGy) G & H styles only
Syringe Filters
ZSSG - -
Code ǀ Diameter Code ǀ Micron Code ǀ Inlet / Outlet Connection Code ǀ Variant Code ǀ Grade Code ǀ Options Code ǀ Pack N°
050 50 mm 010 0.10 µm F Female Luer Lock P Pharmaceutical N Non-sterile S Standard 025 25 per box
020 0.20 µm G Stepped Hosebarb
045 0.45 µm
Parker domnick hunter has a continuous policy of product development and although the Company
reserves the right to change specifications, it attempts to keep customers informed of any alterations.
This publication is for general information only and customers are requested to contact our Process
Filtration Sales Department for detailed information and advice on a products suitability for specific
applications. All products are sold subject to the company’s Standard conditions of sale.
12/08 Rev. 3A