class today, we ask for your presence and guidance. We know that without you, we can do nothing. We ask that you open our minds and hearts to receive knowledge and understanding we will be taught. Help us to be attentive and respectful to our teachers and classmates. We pray for the ability to apply what we learn to our daily lives. We give you all the glory and honor. Amen How do Nervous System and Endocrine System Work together? The nervous system is a physically connected network of cells, tissues, and organs that controls thoughts, movements, and simpler life processes, such as swallowing. The endocrine system is a collection of physically disconnected organs that helps control growth, development, and responses to your environment, such as body temperature. The Nervous and Endocrine system work together because they are both communicators of the body. The nervous system receives and sends out information about activities within the body. It also monitors and responds to the changes in the environment. This coordination: Enables the body to carry out its activities and functions efficiently and smoothly. Enables the body to respond to stimuli effectively so as to take action quickly and avoid injury. Enables the nervous system to detect changes in the body or environment and relate it to the endocrine system for producing the hormones required for join response and action. Without coordination between the nervous system and the endocrine system, the body cannot function as a whole. Maintaining Homeostasis The Body’s Communication Systems Help Maintain Homeostasis. The human body is made up of trillions of cells that all work together for the maintenance of the entire organism. Maintaining a constant internal environment by providing the cells with what they need to survive (oxygen, nutrients, and removal of waste) is necessary for the wellbeing of individual cells and of the entire body. The many processes by which then body controls its internal environment are collectively called homeostasis. The complementary activity of major body systems maintains homeostasis. Both the nervous system and the endocrine system are important in enabling the body to maintain homeostasis. Homeostasis depends on the ability of different systems in your body to communicate with one another. To maintain homeostasis, messages must be generated, delivered, interpreted, and acted upon by your body. The nervous system and the endocrine system are the communication networks that allow you to respond to changes in your environment countless times each day. To achieve homeostasis, the nervous system and the endocrine system maintain a normal range of the following variables: a. Body temperature, b. Amount of water in the body, c. Amount of metabolic waste in the cell, d. Blood calcium levels, Hormones in the blood Most body systems maintain homeostasis by using feedback mechanisms. When the brain receives messages from the body about an internal change in one of its systems, it works to restore the system to its normal state. The levels of hormones in the body are controlled by feedback. It is important that the amount of hormones in the body is kept at the right level. Feedback Regulation Loops The endocrine system plays an important role in homeostasis because hormones regulate the activity of body cells. The release of hormones into the blood is controlled by a stimulus. For example, the stimulus either causes an increase or a decrease in the amount of hormone secreted. Then, the response to a stimulus changes the internal conditions and may itself become a new stimulus. This self-adjusting mechanism is called feedback regulation. Feedback regulation occurs when the response to a stimulus has an effect of some kind on the original stimulus. The type of response determines what the feedback is called. Negative feedback occurs when the response to a stimulus reduces the original stimulus. Positive feedback occurs when the response to a stimulus increases the original stimulus. Negative feedback is the most common feedback loop in biological systems. The system acts to reverse the direction of change. Since this tends to keep things constant, it allows the maintenance of homeostatic balance. Control of blood glucose level is an example of negative feedback. Blood glucose concentration rises after a meal (the stimulus). As blood glucose increases, insulin is released, causing the blood glucose to drop. If the blood glucose level is too low, the pancreas releases the hormone glucagon resulting in an increase in blood glucose. This travels to the liver in the blood and causes the break-down of glycogen into glucose. The glucose enters the blood stream and glucose levels increase back to normal. Thermoregulation is another example of negative feedback. When body temperature rises, receptors in the skin and the hypothalamus sense the temperature change. The temperature change (stimulus) triggers a command from the brain. This command causes a response (the skin makes sweat and blood vessels near the skin surface dilate), which helps decrease body temperature. Positive feedback is less common in biological systems. Positive feedback acts to speed up the direction of change. An example of positive feedback is lactation (milk production). As the baby suckles, nerve messages from the mammary glands cause the hormone prolactin, to be secreted by the pituitary gland. The more the baby suckles, the more prolactin is released, which stimulates further milk production. How do Nervous System and Endocrine System Work together? Human Disorders 1. Neurodegenerative Disorders are both neurodegenerative disorders characterized by loss of nervous system functioning. a. Alzheimer’s disease is an irreversible, progressive brain disorder that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks. b. Parkinson’s disease is a brain disorder that leads to shaking, stiffness, and difficulty with walking, balance, and coordination. Human Disorders 2. Neurodevelopmental Disorders are neurodevelopmental disorders that arise when nervous system development is disrupted. a. Autism or autism spectrum disorder (ASD) refers to a broad range of conditions characterized by challenges with social skills, repetitive behaviors, speech, and nonverbal communication. b. Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders of childhood. It is usually first diagnosed in childhood and often lasts into adulthood. Children with ADHD may have trouble paying attention, controlling impulsive behaviors (may act without thinking about what the result will be), or be overly active. Human Disorders 3.Neurodevelopmental Disorders: Mental Illnesses a. Schizophrenia a psychiatric diagnosis denoting a persistent, often chronic, mental illness variously affecting behavior, thinking, and emotion. b. Depression is caused by a decrease in norepinephrine and serotonin neurotransmission. Human Disorders 4. Other Neurological Disorders a. Epilepsy a medical condition in which the sufferer experiences seizures (or convulsions) and blackouts b. Stroke the loss of brain function arising when the blood supply to the brain is suddenly interrupted. 5. Gigantism is a serious condition that is nearly always caused by an adenoma, a tumor of the pituitary gland. Gigantism occurs in patients who had excessive growth hormone in childhood. The pituitary tumor cells secrete too much growth hormone (GH), leading to many changes in the body. 6. Growth hormone deficiency (GHD), also known as dwarfism or pituitary dwarfism, is a condition caused by insufficient amounts of growth hormone in the body.