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  • Fts Perhitungan Modul 6

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    iyas utomo
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    The document discusses quality control calculations for tablets, including measurements taken before and after coating. It analyzes the uniformity of weight, thickness, hardness, fragility, and disintegration time of the tablets. For each measurement, it provides the average, standard deviation, and coefficient of variation to determine if the values meet specifications. The results show that the weight, thickness, and hardness were more uniform after coating compared to before coating.

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    The document discusses quality control calculations for tablets, including measurements taken before and after coating. It analyzes the uniformity of weight, thickness, hardness, fragility, and disintegration time of the tablets. For each measurement, it provides the average, standard deviation, and coefficient of variation to determine if the values meet specifications. The results show that the weight, thickness, and hardness were more uniform after coating compared to before coating.

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    7 views5 pages

    Fts Perhitungan Modul 6

    Uploaded by

    iyas utomo
    The document discusses quality control calculations for tablets, including measurements taken before and after coating. It analyzes the uniformity of weight, thickness, hardness, fragility, and disintegration time of the tablets. For each measurement, it provides the average, standard deviation, and coefficient of variation to determine if the values meet specifications. The results show that the weight, thickness, and hardness were more uniform after coating compared to before coating.

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    © All Rights Reserved
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    of 5

    H.

    PERHITUNGAN KONTROL KUALTITAS TABLET

    a. KESERAGAMAN BOBOT
    - Keseragaman bobot tablet sebelum disalut
    SD = 9,476

    CV = 9,476/318,585 x 100 %

    = 2,974 %

    Persyaratan baik CV <5%, sehingga keseragaman bobot memenuhi

    - Keseragaman bobot tablet sesudah disalut


    SD = 8,143

    CV = 8,143/436,67 x 100%

    = 1,864 %

    Persyaratan baik CV <5%, sehingga keseragaman bobot memenuhi

    - Selisih Penambahan Bobot


    Rerata ( x ) 318,585 436,67 = 118,085

    SD 1,333

    CV 2,974 1,864 = 1,11

    - Penyimpangan bobot rata-rata:


    Sebelum
    A = 334,515 302,655
    B = 350,495 286,725
    Sesudah
    A = 480,337- 393,003
    B = 458,5- 414,84

    b. KETEBALAN TABLET
    - Sebelum disalut
    Rerata = 0,53

    SD = 6,32 x 10^-3

    - Setelah disalut
    Rerata = 0,607

    SD = 3,26 x 10^-3
    - Selisih penambahan tebal
    Rerata 0,077

    SD 3,06 x 10^-3

    c. KEKERASAN
    - Sebelum disalut
    Rerata = 14,79

    SD = 0,84

    - Sesudah disalut
    Rerata = 18,67

    SD = 1,10

    - Selisih penambahan keras


    Rerata 18,67 + 14,79 / 2 = 16,82

    SD 1,10 + 0,84 / 2 = 0,97

    d. KERAPUHAN TABLET
    - Sebelum disalut
    Rerata = 5,33

    SD = 0,03

    CV (%) = 0,563 %

    % = 40,54

    - Setelah disalut
    Rerata = 6,76

    SD = 0,06

    CV (%) = 0,88 %

    % = 92,06

    e. WAKTU HANCUR TABLET


    - Sebelum disalut
    - Retara = 5,17
    - SD =
    - CV (%) =
    - Setelah disalut
    - Rerata = 7,5
    - SD =
    - CV (%) =

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