INTERNATIONAL SCHOOL OF ASIA

AND THE PACIFIC- KALINGA

COLLEGE OF PHARMACY

PREPARATION NO. 4
TITLE OF EXPERIMENT: ZINC OXIDE
PASTE, USP

I. OBJECTIVE: To prepare Zinc Oxide Paste.

II. MATERIALS:
Water bath Digital Balance
Spatula Watch glass

III. FORMULATION: based on this formulation prepare only 50 grams

Zinc oxide.................................................125g
Starch.......................................................120g
White Petrolatum.......................................5g
To make.....1000g

IV. COMPOUNDING PROCEDURE:

1. Weigh the needed ingredients accurately.
2. Triturate the Zinc oxide and Starch in a mortar and pestle.
3. Incorporate the powder mixture into a small portion of white petrolatum until a smooth nucleus is
formed.
4. Add the rest of the white petrolatum portion by portion until a smooth paste is obtained.
5. Place in an appropriate container.
6. Label the container properly.

V. QUESTIONS FOR RESEARCH:

1. What are pastes?

2. How do pastes differ from ointments?
3. What are the precautions when using pastes?
GROUP NAME: PHARCEN___ WRITTEN REPORT SCORE:
RESEARCH SCORE
DATE PERFORMED: ___JULY 30, 2021_
PRODUCT SCORE:

A. PRODUCT INFORMATION SHEET
Synonyms/ Latin Names
Therapeutic classification
Indication
Description of the Finished Product
Method(s) of Preparation Used
Appropriate Container for the Product Plastic ointment jar
Storage Condition
Amount of Product Prepared
Calculations for Formula Adjustment
•FORMULATE 50 grams
Zinc Oxide 125 g
Starch 120 g
White petroleum 5 g
To make 1000 mL
Factor(F)= _ amount desired_
ZINC OXIDE PASTE, USP
Lassar's Plain Zinc Paste, Compound Paste Zinc Oxide
Topical Drug
- medication that is applied to a particular place on or in
the body.
• used for diaper rash
•Antiseptic; used to protect skin from being irritated and
wet caused by diaper use.
•Used widely in the treatment of ivy poisoning, seborrhea,
eczema, psoriasis and pruritus
•This medicine is available as an (OTC) product
•Dries the oozing and weeping of poison
Zinc Oxide Paste contains not less than 24.0 percent and not
more than 26.0 percent of ZnO. The product has mild
astringent properties and works as an antipyretic in which it
can be used for skin irritations such as rash, burns, and as a
skin protectant.
•Lay out the proper amount of ingredients for the procedure
1. Place the zinc oxide to the porcelain mortar and add
the proper amount of starch with it.
2. Triturate the zinc oxide and starch until it’s a thin
fine homogenous product.
3. After mixing it thoroughly, put the triturated zinc
oxide and starch into the glass tile for the levigation
process.
*use a spatula to get all the mixture form the mortar
to the tile.
4. Incorporate the mixture with the white petroleum
in the glass tile portion by portion. *Levigate
properly the mixture.
5. Place the levigated zinc oxide, starch and white
petroleum into a plastic ointment jar.
*Make sure there is no product on the side of the
rim and compact it.
6. The last step is to properly label the zinc oxide
paste
Preserve in well-closed containers, and avoid prolonged
exposure to temperatures exceeding 30 degrees. Avoid
excessive heat.
50 g
 Amount of formula

F=__50 g____= 0.05

1000 mL

×0.05
Zinc Oxide 125 g 6.25 g
Starch 120 g 6g
White petroleum 5g 0.25 g
1000 mL to make 50 g

B. PRODUCT FORMULATION SHEET

INGREDIENT USE IN THE FORMULA PHYSICAL DESCRIPTION

Zinc Oxide Used in the formula as the active yellow-gray granular solid with no
ingredient odor. It is insoluble in water

Starch Filler, dis-integrant, absorbent used white, tasteless and odorless powder
to render ointments firm or paste- that is insoluble in cold water or
like; binder; demulcent alcohol.

White petroleum Used as Ointment base; and a Colorless-white waxy paste

levigating agent

C. LABELING INFORMATION (Attach Product Label)

FORMULATION: Mfg. lic. No.: ljjj/2021

Zinc oxide……………6.25g Batch No.: 1540
Starch………………..6g Mfg. Date: July 2021
White Petrolatum……0.25g MRP.Rs: 55(inclusive of all taxes)

INDICATIONS:
Skin protectant
ZINC OXIDE PASTE
Mild astringent USP 50g
Antiseptic Antiseptic/Skin Protectant
Treatment of seborrhea, eczema,
psoriasis and pruritus

PRECAUTIONS:
For external use only.
Keep out of reach of children.
If swallowed, get medical help.
Ask your healthcare professional
how you should dispose of any
medicine you do not use.

D. ANSWERS TO QUESTIONS FOR RESEARCH

1. What are pastes?

•Pastes are semi-solid, homogeneous formulations with high concentrations of insoluble

powdered substances dispersed in a suitable base for medicinal or cosmetic use. Due to a large
number of powdered ingredients in the formulation, pastes are typically more absorptive, less greasy,
and stiffer in consistency compared to ointments. They are mostly water-based products that have
good adhesion to the skin, intended for application on the mucous membrane, oral cavity, and the skin.

2. How do pastes differ from ointments?

The major difference between paste and ointment is that the paste is a soft mixture that
contains a large amount of finely powdered solids, while ointment is homogenous semisolid dosage
forms contain medicaments that are generally suspended or emulsified, or dissolved in the base.

• Pastes contain a large amount of finely powdered solids, whereas ointments contain less amount of finely
powdered solids than paste.
•The paste is less greasy not transparent than ointment, whereas, ointment is greasy than paste.
•Pastes are mostly water-based products, whereas ointments are mostly oil-based formulations.
•The paste is a stiff and thick product, while the ointment is soft.
•The paste may be applied with a spatula, whereas, the ointment is simply applied to the skin.
•Pastes are more viscous than ointments, while ointments are usually less viscous than pastes.
•The pastes are less penetrating than ointments, while ointments are more penetrating than pastes.
•The paste forms a protective layer in the region where it is applied, whereas the ointment is used as an
emollient or protective for the skin.
•The pharmaceutical ointment lasts longer at the application site than the paste, which releases the drug
for a longer period.
•Pastes have a lower macerating effect, while ointments have a higher macerating effect.
•As compared to the pastes, the ointments are usually greasy and difficult to clean.
•The paste does not spread more easily on the skin than the ointment, while the ointment is more easily
spread on the skin.
 3. What are the precautions when using pastes?

-If you or your child's symptoms do not improve within 7 days, or if they become worse, check with your
doctor. If you or your child accidentally swallow the medicine, call the Poison Control Center right away.
-For external use only.
-Stop and as a doctor if condition worsens.

REFERENCES:
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=7b42655b-2163-4637-9f5d-
1d2efa1bdf1d&type=display

https://chrominfo.blogspot.com/2021/05/difference-between-paste-and-ointment.html?m=1

https://www.webmd.com/drugs/2/drug-62093/lassars-paste-topical/details

https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=7b42655b-2163-4637-9f5d-
1d2efa1bdf1d&type=display

E. EVALUATION

PHARCEN GRP MEMBERS FUNCTION REMARKS

Mendoza, Jhunlaine Kate G.
Javier, Ailyn A.
Callueng, Christian Dale
Bang-I, Geraldine
Dumagdag, Criza Rose
Tolentino, Sandy
Sitdogan, Michelle
LEADER/ COMPILER,
CALCULATIONS PART,
PRODUCT INFORMATION SHEET,
QUALITY ASSURANCE
ANSWERS TO QUESTIONS FOR
RESEARCH, PRODUCT
FORMULATION SHEET,
RESEARCHER
ANSWERS TO QUESTIONS FOR
RESEARCH
ANSWERS TO QUESTIONS FOR
RESEARCH
ANSWERS TO QUESTIONS FOR
RESEARCH
ANSWERS TO QUESTIONS FOR
RESEARCH
PRODUCT FORMULATION SHEET
COMPLETED
COMPLETED
COMPLETED
DID NOT PARTICIPATE OR DID
NOT DO HIS/ HER PART
DID NOT PARTICIPATE OR DID
NOT DO HIS/ HER PART
DID NOT PARTICIPATE OR DID
NOT DO HIS/ HER PART
DID NOT PARTICIPATE OR DID
NOT DO HIS/ HER PART

SUBMITTED TO: ARCHIMEDES O. BAYQUEN, RPh, MPH

Laboratory Instructor

GRADING Rubrics:

PHARCEN SCORE REMARKS

 COMPLETENESS AND ACCURACY OF DATA AND
INFORMATION
• PRODUCT INFORMATION SHEET- 10 POINTS
• PRODUCT FORMULATION SHEET- 10 POINTS
• LABELING INFORMATION- 15 POINTS
• ANSWERS TO QUESTIONS- 20 POINTS
QUALITY OF OUTPUT

TIMELINESS OF SUBMISSION

INDIVIDUAL CONTRIBUTION OF EACH STUDENT

REFERENCES AT LEAST 3 CITATIONS

TOTAL