INNOVA BIOMED INSTRUMENTS LIMITED

Add:Lucky centre,165 Wanchai Road,Wanchai, Hong Kong

Qingdao Innova Bio-Meditech Co., Ltd.
Add:1212,#5 building,No. 176 Jufeng Road,Qingdao,China
Tel.: 0086-532-8789 0634 Email:info@innobiomed.com

年产 5 吨透明质酸（HA)项目主要设备清单

Annual production of 5 tons of hyaluronic acid (HA) project main equipment list 2016.8.25

该技术菌种发酵罐产量 7g/L 以上，分子量 100-180 万 Dao，提取率＞60%，化妆品级透明质酸

The yield of the strain fermentation tank of this technology is more than 7g/L, the molecular weight is 100-1800,000 Dao, the extraction rate

is >60%, cosmetic grade hyaluronic acid

1
 INNOVA BIOMED INSTRUMENTS LIMITED
Add:Lucky centre,165 Wanchai Road,Wanchai, Hong Kong
Qingdao Innova Bio-Meditech Co., Ltd.
Add:1212,#5 building,No. 176 Jufeng Road,Qingdao,China
Tel.: 0086-532-8789 0634 Email:info@innobiomed.com

S/N Equipments QTY User requirement specification（factory）

公称体积（下封头+筒体）500L；介质为粘性发酵液。
上下椭圆封头；夹套加热；装液系数最大 80%；
耳式支撑 4 个；搅拌采用顶搅拌；
物料接触的主体材质为 304 不锈钢；设计压力为 P 内＝0.3Mpa，P 夹＝0.4Mpa；设计温度 150℃；罐体内外抛光精度 Ra≤0.4；
罐顶另预留 1～2 个接口，罐体也应多预留一个接口（至少有四个接口） ；罐顶式机械密封系统；
高性能搅拌桨（二挡：两层弯叶涡轮浆） ，消泡桨；
交流调速电机（德国 SEW） ，无级调速，60~700rpm±1%；
变频器无级，搅拌叶高度可调；
恒温水箱加热，循环泵强制循环，气动阀门自动控制(冷却水+5℃)~50℃±0.2℃，温度探头（进口铂电阻）；
2.00-12.00±0.05pH，通过补加酸碱自动控制，pH 电极（武汉能世）及屏蔽导线(武汉能世)，进碱气动阀门控制，自动流加；
DO 检测 0-150±3%,显示精度 0.1%，电极及屏蔽导线；
通气量气动阀门控制，排气气动隔膜阀控制，V 锥风量计显示，流量调节范围：0~500L/min，空气精过滤器过滤精度 0.01μ；
种子罐
1 2 压力表显示；带液位显示或液位压力数显。
Seed tank
接触工艺物料和发酵液的管道、阀门、管件等均为 304 钢制作，与物料接触的阀门选用隔膜阀，各管路做相应处理，达到
GMP 要求。
气动阀门、压力显示、风流量显示、温度显示、PH 显示、液位显示等接入 DCS 控制电脑。
Nominal volume (bottom head + barrel) 500L; medium is viscous fermentation broth.
Upper and lower elliptical heads; jacket heating; liquid filling coefficient up to 80%;
4 ear supports; Stirring with top stirring;
The material of the main body in contact with the material is 304 stainless steel; the design pressure is P inside = 0.3Mpa, P clip =
0.4Mpa; the design temperature is 150°C; the polishing accuracy of the inside and outside of the tank is Ra≤0.4;
Reserve another 1 to 2 ports on the tank top, and reserve one more port on the tank body (at least four ports); tank top
mechanical seal system;
High-performance stirring paddle (second gear: two-layer curved blade turbine paddle), defoaming paddle;
AC speed regulating motor (Germany SEW), stepless speed regulation, 60~700rpm±1%;

2
 INNOVA BIOMED INSTRUMENTS LIMITED
Add:Lucky centre,165 Wanchai Road,Wanchai, Hong Kong
Qingdao Innova Bio-Meditech Co., Ltd.
Add:1212,#5 building,No. 176 Jufeng Road,Qingdao,China
Tel.: 0086-532-8789 0634 Email:info@innobiomed.com
The frequency converter is stepless, and the height of the stirring blade is adjustable;
Constant temperature water tank heating, forced circulation of circulating pump, automatic control of pneumatic valve (cooling
water +5°C)~50°C±0.2°C, temperature probe (imported platinum resistor);
2.00-12.00±0.05pH, automatically controlled by adding acid and alkali, pH electrode (Wuhan Nengshi) and shielded wire (Wuhan
Nengshi), alkali inlet pneumatic valve control, automatic feeding;
DO detection 0-150±3%, display accuracy 0.1%, electrodes and shielded wires;
Air flow pneumatic valve control, exhaust pneumatic diaphragm valve control, V-cone air flow meter display, flow adjustment
range: 0~500L/min, fine air filter filtration accuracy 0.01μ; pressure gauge display; liquid level display or liquid level pressure
digital display.
The pipes, valves, and pipe fittings in contact with process materials and fermentation liquid are all made of 304 steel. The valves
in contact with materials are diaphragm valves, and each pipeline is treated accordingly to meet GMP requirements.
Pneumatic valves, pressure display, wind flow display, temperature display, PH display, liquid level display, etc. are connected to
the DCS control computer.
公称体积（下封头+筒体）5m³；介质为粘性发酵液 。
上下椭圆封头；夹套加热；装液系数最大 80%；
底支撑式支脚 4 个；搅拌采用顶搅拌；
物料接触的主体材质为 304 不锈钢；
设计压力为 P 内＝0.3Mpa，P 夹＝0.4Mpa；设计温度 150℃；
罐体内外抛光精度 Ra≤0.4；
发酵罐 Bioreactor
罐顶另预留 1～2 个接口，罐体也应多预留一个接口（至少有四个接口） ；罐顶式机械密封系统；
2 tanks 2
高性能搅拌桨（三挡：底部两层弯叶涡轮浆，顶部单层轴流搅拌） ，消泡桨；
交流调速电机（德国 SEW） ，无级调速，60~400rpm±1%；
变频器无级，搅拌叶高度可调；
恒温水箱加热，循环泵强制循环，气动阀门自动控制(冷却水+5℃)~50℃±0.2℃，温度探头（进口铂电阻）；
2.00-12.00±0.05pH，通过补加酸碱自动控制，pH 电极（武汉能世）及屏蔽导线(武汉能世)，进碱气动阀门控制，自动计量；
补料进料阀气动阀门控制；
DO 检测，0-150±3%,显示精度 0.1%，电极及屏蔽导线（武汉能世） ；

3
 INNOVA BIOMED INSTRUMENTS LIMITED
Add:Lucky centre,165 Wanchai Road,Wanchai, Hong Kong
Qingdao Innova Bio-Meditech Co., Ltd.
Add:1212,#5 building,No. 176 Jufeng Road,Qingdao,China
Tel.: 0086-532-8789 0634 Email:info@innobiomed.com
通气量气动阀门控制，排气气动隔膜阀控制，V 锥风量计显示，流量调节范围：0~6m3vvm，空气精过滤精度 0.01μ；压力
表显示；带液位显示或液位压力数显。
接触工艺物料和发酵液的管道、阀门、管件等均为 304 钢制作，与物料接触的阀门选用隔膜阀，各管路做相应处理，达到
GMP 要求。
气动阀门、压力显示、风流量显示、温度显示、PH 显示、液位显示等接入 DCS 控制电脑。
Nominal volume (bottom head + barrel) 5m³; medium is viscous fermentation broth.
Upper and lower elliptical heads; jacket heating; liquid filling coefficient up to 80%;
4 bottom support feet; top stirring is used for stirring;
The main material in contact with the material is 304 stainless steel;
The design pressure is P inside = 0.3Mpa, P clip = 0.4Mpa; the design temperature is 150°C;
The polishing precision of the inside and outside of the tank is Ra≤0.4;
Reserve another 1 to 2 ports on the tank top, and reserve one more port on the tank body (at least four ports); tank top
mechanical seal system;
High-performance stirring paddle (third gear: two layers of curved-blade turbine paddle at the bottom, single-layer axial flow
stirring at the top), defoaming paddle;
AC speed regulating motor (Germany SEW), stepless speed regulation, 60~400rpm±1%;
The frequency converter is stepless, and the height of the stirring blade is adjustable;
Constant temperature water tank heating, forced circulation of circulating pump, automatic control of pneumatic valve (cooling
water +5°C)~50°C±0.2°C, temperature probe (imported platinum resistor);
2.00-12.00±0.05pH, automatically controlled by adding acid and alkali, pH electrode (Wuhan Nengshi) and shielded wire (Wuhan
Nengshi), alkali inlet pneumatic valve control, automatic metering; feeding valve pneumatic valve control;
DO detection, 0-150±3%, display accuracy 0.1%, electrode and shielded wire (Wuhan Nengshi);
Air flow pneumatic valve control, exhaust pneumatic diaphragm valve control, V-cone air flow meter display, flow adjustment
range: 0~6m3vvm, air fine filtration accuracy 0.01μ; pressure gauge display; liquid level display or liquid level pressure digital
display.
The pipes, valves, and pipe fittings in contact with process materials and fermentation liquid are all made of 304 steel. The valves
in contact with materials are diaphragm valves, and each pipeline is treated accordingly to meet GMP requirements.

4
 INNOVA BIOMED INSTRUMENTS LIMITED
Add:Lucky centre,165 Wanchai Road,Wanchai, Hong Kong
Qingdao Innova Bio-Meditech Co., Ltd.
Add:1212,#5 building,No. 176 Jufeng Road,Qingdao,China
Tel.: 0086-532-8789 0634 Email:info@innobiomed.com
Pneumatic valves, pressure display, wind flow display, temperature display, PH display, liquid level display, etc. are connected to
the DCS control computer.
2.5m³；介质为配料发酵液
上下椭圆封头；夹套加热；装液系数 80%；
耳式支撑 4 个；搅拌采用顶搅拌；
物料接触的主体材质为 304 不锈钢；设计压力为 P 内＝0.3Mpa，P 夹＝0.4Mpa；设计温度 150℃；罐体内外抛光精度 Ra≤0.4； ；
罐顶另预留 1～2 个接口，罐体也应多预留一个接口（至少有四个接口） ；罐顶式机械密封系统；
高性能搅拌桨（二挡：两层弯叶涡轮浆） ，消泡桨；
交流调速电机（德国 SEW） ，无级调速，60~700rpm±1%；
变频器无级，搅拌叶高度可调；
恒温水箱加热，循环泵强制循环，气动阀门自动控制(冷却水+5℃)~50℃±0.2℃，温度探头（进口铂电阻）；
通气量气动阀门控制，空气精过滤器过滤精度 0.01μ；排气隔膜阀手动控制，压力表显示；带液位显示或液位压力数显。
接触工艺物料和发酵液的管道、阀门、管件等均为 304 钢制作，与物料接触的阀门选用隔膜阀，各管路做相应处理，达到
GMP 要求。
补料罐
3 1 气动阀门、压力显示、温度显示、液位显示等接入 DCS 控制电脑。
Feeding tank
2.5m³; the medium is the ingredient fermentation liquid
Upper and lower elliptical heads; jacket heating; liquid filling coefficient 80%;
4 ear supports; Stirring with top stirring;
The material of the main body in contact with the material is 304 stainless steel; the design pressure is P inside = 0.3Mpa, P clip =
0.4Mpa; the design temperature is 150°C; the polishing accuracy of the inside and outside of the tank is Ra≤0.4;
Reserve another 1 to 2 ports on the tank top, and reserve one more port on the tank body (at least four ports); tank top
mechanical seal system;
High-performance stirring paddle (second gear: two-layer curved blade turbine paddle), defoaming paddle;
AC speed regulating motor (Germany SEW), stepless speed regulation, 60~700rpm±1%;
The frequency converter is stepless, and the height of the stirring blade is adjustable;
Constant temperature water tank heating, forced circulation of circulating pump, automatic control of pneumatic valve (cooling
water +5°C)~50°C±0.2°C, temperature probe (imported platinum resistor);

5
 INNOVA BIOMED INSTRUMENTS LIMITED
Add:Lucky centre,165 Wanchai Road,Wanchai, Hong Kong
Qingdao Innova Bio-Meditech Co., Ltd.
Add:1212,#5 building,No. 176 Jufeng Road,Qingdao,China
Tel.: 0086-532-8789 0634 Email:info@innobiomed.com
Pneumatic valve control of ventilation volume, fine air filter filtration accuracy of 0.01μ; manual control of exhaust diaphragm
valve, pressure gauge display; with liquid level display or liquid level pressure digital display.
The pipes, valves, and pipe fittings in contact with process materials and fermentation liquid are all made of 304 steel. The valves
in contact with materials are diaphragm valves, and each pipeline is treated accordingly to meet GMP requirements.
Pneumatic valves, pressure display, temperature display, liquid level display, etc. are connected to the DCS control computer.
小料罐
Feeding tank 500L；设计压力 0.3MPa；材质 304；带夹套，压力表，泄压阀，液位计
4 2
(small) 500L; design pressure 0.3MPa; material 304; with jacket, pressure gauge, pressure relief valve, liquid level gauge

2.5m³；筒体φ1200mm×2200mm；设计压力 0.3Mpa，上下椭圆封头，底支撑式支脚 4 个；内外抛光，抛光精度 Ra≤0.4；材

质 316L 不锈钢；无菌空气混合，空气进口以测斜进入。带有可视液位计，抗压抗腐蚀，带压力表显示。介质为浓碱液。
碱液罐
5 1 2.5m³; cylinder φ1200mm×2200mm; design pressure 0.3Mpa, upper and lower elliptical heads, 4 bottom support feet; internal
Base tank
and external polishing, polishing accuracy Ra≤0.4; material 316L stainless steel; . With visual liquid level gauge, anti-pressure and
anti-corrosion, with pressure gauge display. The medium is concentrated lye.
2.5m³；筒体φ1200mm×2200mm；常压，上下椭圆封头，底支撑式支脚 4 个；玻璃钢或 316L。带有可视液位计，抗压抗腐
蚀，带压力表显示。介质为烯酸液。
酸液罐
6 1 2.5m³; cylinder φ1200mm×2200mm; normal pressure, upper and lower oval heads, 4 bottom support feet; glass fiber reinforced
Acid tank
plastic or 316L. With visual liquid level gauge, anti-pressure and anti-corrosion, with pressure gauge display. The medium is alkene
acid solution.
2.5m³；筒体φ1200mm×2200mm；上下椭圆封头，底支撑式支脚 4 个，内蛇管加热，岩棉保温 60mm，外包不锈钢，内外
抛光，抛光精度 Ra≤0.4；外带可视液位计；带温度传感器， （蒸汽加热） 。设计常压，设计温度 100℃；带温度显示；材质
304。蒸汽加热
热水罐
6 2 2.5m³; cylinder φ1200mm×2200mm; upper and lower elliptical heads, 4 bottom support feet, inner coil heating, rock wool
Hot water tank
insulation 60mm, outsourcing stainless steel, internal and external polishing, polishing accuracy Ra≤0.4; external visual liquid level
gauge; With temperature sensor, (steam heating). Design normal pressure, design temperature 100°C; with temperature display;
material 304. steam heating

6
 INNOVA BIOMED INSTRUMENTS LIMITED
Add:Lucky centre,165 Wanchai Road,Wanchai, Hong Kong
Qingdao Innova Bio-Meditech Co., Ltd.
Add:1212,#5 building,No. 176 Jufeng Road,Qingdao,China
Tel.: 0086-532-8789 0634 Email:info@innobiomed.com
离心泵 Q=5m3/h，H=30m；材质 321，卫生级。用于 CIP 清洗进程泵和回程泵。
7 1
centrifugal pump Q=5m3/h, H=30m; material 321, sanitary grade. For CIP cleaning process pumps and return pumps.
Q=5m3/h，H=30m；材质 321，卫生级。根据发酵罐换热需求安装，用来进行发酵罐的换热。
离心泵
8 1 Q=5m3/h, H=30m; material 321, sanitary grade. It is installed according to the heat exchange requirements of the fermenter and
centrifugal pump
used for heat exchange of the fermenter.
换热器 用于发酵液的换热，温度 37℃升高至 70-75℃
9 1
Heat Exchanger Used for heat exchange of fermentation broth, temperature rises from 37°C to 70-75°C
2.5m³；筒体φ1200mm×2200mm；设定压力常压；平顶；锥底，底角 150°，底支撑式支脚 4 个；内外抛光，抛光精度 Ra≤0.4。
二档桨式搅拌，变频电机，搅拌转速 60rpm。材质 304。罐内带精确体积刻度。
配料罐
10 1 2.5m³; cylinder φ1200mm×2200mm; set pressure and normal pressure; flat top; cone bottom, bottom angle 150°, 4 bottom
Ingredients tank
support feet; internal and external polishing, polishing accuracy Ra≤0.4. Second gear paddle stirring, frequency conversion motor,
stirring speed 60rpm. Material 304. Tank with precise volume scale.
离心泵 离心泵，Q=5m3/h，H=30m，材质 321，卫生级，配料，酸液，热水，耐酸碱
10 4
centrifugal pump Centrifugal pump, Q=5m3/h, H=30m, material 321, sanitary grade, ingredients, acid liquid, hot water, acid and alkali resistance
PLC 控制 配备 pH 电极、溶氧电极、消泡电极等
12 1套
PLC control Equipped with pH electrode, dissolved oxygen electrode, defoaming electrode, etc.
15m³；常压，带保温；内外抛光，抛光精度 Ra≤0.4；顶端椭圆封头，筒体φ2200mm×4000mm；底支撑式支脚 4 个；顶搅
拌，转速 70rpm，温度显示；材质 304；介质水溶液，罐外设循环换热器，热水换热，带 pH 显示
溶解罐
13 1 15m³; normal pressure, with heat preservation; internal and external polishing, polishing accuracy Ra≤0.4; top oval head, cylinder
Dissolving tank
φ2200mm×4000mm; bottom support feet 4; top stirring, speed 70rpm, temperature display; material 304; medium aqueous
solution, Circulation heat exchanger outside the tank, hot water heat exchange, with pH display
板式换热器 板片材质为 304（多为卫生级铬片） ；加热水温度至 60-65℃，调整溶液温度，以热水进行换热，同时用于料液的升温。
14 Plate heat 1 The plate material is 304 (mostly sanitary grade chrome); heat the water temperature to 60-65 ℃, adjust the solution
exchanger temperature, use hot water for heat exchange, and at the same time, it is used to raise the temperature of the material liquid.
离心泵 Q=10m3/h，H=30m，材质 321，卫生级。(一备一用)
15 2
centrifugal pump Q=10m3/h, H=30m, material 321, sanitary class. (Use alone)

7
 INNOVA BIOMED INSTRUMENTS LIMITED
Add:Lucky centre,165 Wanchai Road,Wanchai, Hong Kong
Qingdao Innova Bio-Meditech Co., Ltd.
Add:1212,#5 building,No. 176 Jufeng Road,Qingdao,China
Tel.: 0086-532-8789 0634 Email:info@innobiomed.com
板框过滤机
40m2；暗流，工作压力 0.35Mpa
16 Plate and frame 1
40m2; undercurrent, working pressure 0.35Mpa
filter
1m³；顶搅拌，居中，二档浆式搅拌,转速 70rpm；材质 304。 硅藻土、活性炭，罐内带刻度尺寸
配料罐
17 2 1m³; top stirring, centering, second gear paddle stirring, speed 70rpm; material 304. Diatomaceous earth, activated carbon, scaled
Ingredients tank
size inside the tank
离心泵 Q=5m3/h，H=30m，材质 321，卫生级。
18 2
centrifugal pump Q=5m3/h, H=30m, material 321, sanitary class
15m³；筒体φ2200mm×4000mm 常压，带保温；内外抛光，抛光精度 Ra≤0.4；顶端椭圆封头，底端椭圆封头。设计温度 100℃；
炭吸罐
温度显示，材质 304；介质水溶液。
19 Charcoal suction 1
15m³; cylinder φ2200mm×4000mm normal pressure, with insulation; internal and external polishing, polishing accuracy Ra≤0.4;
tank
top oval head, bottom oval head. Design temperature 100°C; temperature display, material 304; medium aqueous solution.
离心泵 Q=10m3/h，H=30m，材质 321，卫生级。
20 1
centrifugal pump Q=10m3/h, H=30m, material 321, sanitary class
板框过滤机
40m2；暗流，工作压力 0.35Mpa，暗流，半自动挤压
21 Plate and frame 1
40m2; undercurrent, working pressure 0.35Mpa, undercurrent, semi-automatic extrusion
filter
轴流泵 用于板框过滤管道流体加压
22 2
axial flow pump for plate and frame filtrationfor pipelinesfluid pressurization
15m³；筒体φ2200mm×4000mm 保温，常压；内外抛光，抛光精度 Ra≤0.4；顶端椭圆封头，底端椭圆封头，设计温度 100℃；
带温度显示，pH 显示
调碱罐
23 1 15m³; cylinder φ2200mm×4000mm heat preservation, normal pressure; internal and external polishing, polishing accuracy
Base tank
Ra≤0.4; top oval head, bottom oval head, design temperature 100°C; with temperature display, pH display

离心泵 Q=10m3/h，H=30m，材质 321，卫生级。

24 1
centrifugal pump Q=10m3/h, H=30m, material 321, sanitary class

8
 INNOVA BIOMED INSTRUMENTS LIMITED
Add:Lucky centre,165 Wanchai Road,Wanchai, Hong Kong
Qingdao Innova Bio-Meditech Co., Ltd.
Add:1212,#5 building,No. 176 Jufeng Road,Qingdao,China
Tel.: 0086-532-8789 0634 Email:info@innobiomed.com
板框过滤机
20m2；暗流，工作压力 0.35Mpa
25 Plate and frame 1
20m2; undercurrent, working pressure 0.35Mpa
filter
周转罐 15m³；筒体φ2200mm×4000mm 常压，保温，带温度 pH 显示，顶搅拌
26 1
Transfer tank 15m³; barrel φ2200mm×4000mm normal pressure, heat preservation, with temperature and pH display, top stirring
20m2，纸板支撑，孔径 0.45um；不锈钢过滤器一般自带进料泵
27 纸板过滤器 1
20m2, cardboard support, pore size 0.45um; stainless steel filter usually comes with a feed pump
超滤设备
截留分子量 1 万，用于过滤除盐和浓缩，处理量为 1T/h， （一备一用）
28 Ultra filtration 1
Molecular weight cut-off 10,000, used for filtration desalination and concentration, with a processing capacity of 1T/h, (Use alone)
system
超滤浓相储罐
Ultrafiltration 用于储存超滤过滤后的盐溶液和小分子蛋白
29 1
Dense Phase Used to store salt solution and small molecular protein after ultrafiltration
Storage Tank
缓冲罐 超滤后用于进入喷雾干燥的储罐，4 立方
30 1
Buffer tank Storage tank for spray drying after ultrafiltration, 4 cubic meters
蒸发量 500L/h，料液处理量，温度 140-210℃， （可用煤、天然气、蒸汽、做能源
喷雾干燥器
31 1 Evaporation capacity 500L/h, material liquid handling capacity, temperature 140-210°C, (source energy can be coal, natural gas,
spray dryer
steam )
震荡筛 防爆，316L；孔径根据产品需要可调筛网
32 1
Shaker Explosion-proof, 316L; the aperture can be adjusted according to the needs of the product
精密包装称 包装秤，封口机
33 1
Precision Packaging Packaging scales, sealing machines
纯净水制备装置
2m3/h，进水为蒸汽冷凝水，带 10T 的纯水储罐，带离泵 10T/h
34 Pure water 1
2m3/h, the inlet water is steam condensed water, with 10T pure water storage tank, 10T/h away from the pump
preparation device

9
 INNOVA BIOMED INSTRUMENTS LIMITED
Add:Lucky centre,165 Wanchai Road,Wanchai, Hong Kong
Qingdao Innova Bio-Meditech Co., Ltd.
Add:1212,#5 building,No. 176 Jufeng Road,Qingdao,China
Tel.: 0086-532-8789 0634 Email:info@innobiomed.com
GMP 车间 D 级净化标准，带空调一体机
35 1
GMP workshop Class D purification standard, with integrated air conditioner
污水处理系统
清洗用水，60 立方处理能力
36 sewage treatment 1
Cleaning water, 60 cubic capacity
system
蒸汽锅炉 3T/h ，烧天然气
37 1
steamer 3T/h, burning natural gas
设备平台
38 3 不锈钢 Stainless steel
Platform
冷却循环水池
按照客户需求定制
39 cooling circulating 1
As requirement
pool
化验室
菌种室 包括常规设备和高端仪器
40
Laboratory Strain Including conventional equipment and high-end instruments
room

10