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  • Antibacterial R-WPS Office

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    Pharmanic By Ruttaba Fatima
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    Bacterial resistance to antibiotics occurs due to various sophisticated mechanisms evolved by bacteria, including drug efflux pumps that provide baseline resistance and help emergence of further resistance mechanisms such as target site modification. Bacteria produce hydrolytic enzymes such as beta-lactamases that inactivate antibiotics like aminoglycosides and break beta-lactam rings. Controlling bacterial drug efflux pumps through structural and genetic studies has allowed better understanding of transport mechanisms, but developing effective pump inhibitors to combat resistance has proven difficult. Combining drugs like sulbactam that inhibits beta-lactamases with ampicillin helps overcome negative effects caused by multidrug resistance pumps.

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    Antibacterial r-WPS Office

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    Bacterial resistance to antibiotics occurs due to various sophisticated mechanisms evolved by bacteria, including drug efflux pumps that provide baseline resistance and help emergence of further resistance mechanisms such as target site modification. Bacteria produce hydrolytic enzymes such as beta-lactamases that inactivate antibiotics like aminoglycosides and break beta-lactam rings. Controlling bacterial drug efflux pumps through structural and genetic studies has allowed better understanding of transport mechanisms, but developing effective pump inhibitors to combat resistance has proven difficult. Combining drugs like sulbactam that inhibits beta-lactamases with ampicillin helps overcome negative effects caused by multidrug resistance pumps.

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    3 views3 pages

    Antibacterial R-WPS Office

    Uploaded by

    Pharmanic By Ruttaba Fatima
    Bacterial resistance to antibiotics occurs due to various sophisticated mechanisms evolved by bacteria, including drug efflux pumps that provide baseline resistance and help emergence of further resistance mechanisms such as target site modification. Bacteria produce hydrolytic enzymes such as beta-lactamases that inactivate antibiotics like aminoglycosides and break beta-lactam rings. Controlling bacterial drug efflux pumps through structural and genetic studies has allowed better understanding of transport mechanisms, but developing effective pump inhibitors to combat resistance has proven difficult. Combining drugs like sulbactam that inhibits beta-lactamases with ampicillin helps overcome negative effects caused by multidrug resistance pumps.

    Copyright:

    © All Rights Reserved
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