CHAPTER-4

S7STEM
S7STEM
DRUG DELVER
MUCOSAL
eAdhueitn
Punchla
LEncehl2 adnantagee
* Antneductien
MuCEndhealen n a n A m i L C e A d

a n d dieadiamtage
sózmLuLAtLQn ,
A
Cm L
ena aou
ud Liai
tU AmA
t sk n a G HLCcaldline

Qystima
PTS2PRINCIPLES
INTRODUCTION &CONCE
OF BlO MUCO-ADHES)ON

BieddheQLen2endhouen moy matiuale

Ao mallHLale
Alati n Aohuch
atteaat Gni Autich vng, 0a
KLdkpather
elegical natue A r e
nntomplod heueA
Kmtinkcal oNA.
t e ales domd
adheAe a Aelogucal tiweueo m
emded huLed _Aine
BiendhaEL=,
BLendhee le the tuem
hslymun te A ASOZALal Auletat
KatimAle
Kaltem he datien
meat
CalSR Lediute eAhMÄumatuly
 cASSMA
Dete
Page.

b12 hsU dun tethe ulatualy ahst

dhhheCch o iehghoie helynta

Xae loMulehed hat adhu to
TuuunhihalLal Auace uch
MmPanno Nem-mucaLuA MUmLana
BieadhoALNA Aclaoupid
BAkadhALen LChanactLgd
cte thout_hOslnK/mUni

2 I
BiendhIeN CAn_ uhGWAunted luy
C Aduwien ente cullune Alehee
Oddhien ke a Aanuiy Aulatancla ih
MAale CGd otc.

Adhen LLCLAN Aultcuncea Le

MEeGUCal auloUhia A c A Acdhoauen

ucaduLveuLg Qllnes yatima uil

 Ahahehwty HeQdhiiign
CAim a t - eui hey
Ahich ACEmgadhLAUe
Qnd Xhmce Canly Ld LL
AAnQelumg
OLedA tum
he miuc8- LiNE
dug diliwhy Aystima nclud ihL
BuLccal diwLY AyAUm
2 Aul-umgualclivh Usim
3 laginal dolinuy uTm
5Naoal
Culan dilinhy ysium
GadiwMY Ahllh

amalukni Ad AHALLd
ymea thim LEnUnEAu QlNiEnAich
ankut
adhwwnt fe thi
MuLeaak thual
Ram AAnUA m Aut 50450m
Un umame
The huhlia
amg Athe
LErhEuten-
 lAsSMALe
Date
Page

hat 95
Lylycohnstuwne Rhude OS-S
HineHal ealte
05-/
CuAQlytepnblune Au high madluulaz
etun eaweung atteched ollg0-
Ancchanidimie

Pniebe-
udnephsinitsi
hnstcla he mucsAa tm the diyLAien
Ha
2Banmen
Aceneiuba ad eien anuo
meleculee nd Lep:_againat AcULg
aehten

Utucue hae Álneng Ashaienal

honehaxtune
4Kulicaluen Laye kuhe tho muceeal
mimlAne MeiAt. goadcckavoda

Riole chaume

hetun
 ASSMAte
Date

c0clhonuen
G_hhmmemuna w nUQuUILd.
UOCAALem
(b Nrot otage"tnekeg am mumaD
Cntoct Juwkuma GAdhLoie lnd
mumamo ethun }uem a 40Ac JLetiUmg
em
t Aullimg e the lieadheeme
CIID n Ahe Acend Afag, at Aentadt
AaltLhLd Jhnolnhtien neIne XHogdhi
nTe KhociÁHCL
Uninhdtien Gh haume hi
Takia hLace Zsu dUmLeal ende_CamAhen
Attle

muceadhluen ts eccuW tha anaeliau

tLailuen Aheuld u Dnge Tham NEN-
AhLe 1ohulSm
HEORIES OF BIDADHESION
(a dnene Acc te hue iheoy
octon HameLCCUA uhan_09EtÓst

ALnnc iAmXun CUHOniLAbunclur

Aie0AullA Ane Umailen Gam
Adhain ACUnA duup te atttuacue
 alAsSMAte
Date
Pege

(AEYUen heoy-,
Mullal cEmtad beliuaun tuse kincna
the matihial adhetto CamAL

chumieal lende 'naulting Lemthlao

Cib wmay LeNAttnt ede- chmucal
nde OUalemi matiune
Cin Cgncany chemical onde Auch,aL
glucheaNe Oce Vamdo Waale yoouC0O
hydnegen & hydiehhole Loende
CCOltwng xh tuno thuseuy A
domumants ahhlLcall e OlLgucd
AAndhine ALLATUMA And OMallaLo
dhiL L_Lontast lehanuoun Un
Vma A gLud Ahaate te ahmad
elegcal Ayom
dheAnEn, JAUmg 4uMnid
And An0nacLak maLen im an
h om2 niLaAod
adhsain iegnbny
AB

Awne A RB nen te Ahg &Melegical

UmaluLal
memlane & hi ue0dhaiug
 elassMat
Date
Page

Qiemy
h 2A

AB
SB AheLud eheime LoaHCOdhooiue
mauak to dhe a
slegicol mimamA.
Ld UALeN husy-
hhelumiit haune MdAha
mwcuom AoA A ciimtduhih
adhaiM end. aha 9actdehth
hich th helymt caume to
mutiou
dmd mAh0AMRLOn
Ce aHactue huy:
t 9ulaio Aho
cdieutt YOahotin

G1CEEJLY
 ASSMAte.

hixeE =ung' medula odosi

= ANadHIA Qnig
LulicoCaktLomatn
unJus

FACTORS AFFACTING MUCO ADHES ON

LAD 1ouymit uatid a l a
1 MOLECOLAR WEIGHT
AMcHLAAVA ith_Öe Maleulm uwigA o
mu uhte iodcco
yAmd thia luu) Thon aMst much DAL_
2. CONC OF ACTINE POL MER

HeddhwALAn
3 FLEXIBILITH OF POLZMER CHAINS
AHu helumiia Stcem ANNA- uynRed t h
c w XAtngth the haun Lch Cam_
muKRdhaw wnch euduucod
A. SPATIAL CONFORMATION
Boaudea MN CAum
nathAhaal Cen&maten AMLu
ical Cen maleL doAMAn
 Page.

CB unmnenmund ulalid Gaadea ali

1PH
PH ImUugmcon the chaoe enAe
leth MUlai amd theheluma
h dugrw nydlnatuen
huacuylic hyinud AMcnLaReAJAIuLIm
PH4- 05 CenuuwnA be AMcnLare
Aughtiyat PH 6-20 Mnd cuckoaw0
Atmoa alkalina ule. OL
2 APPLIED STRENGTH
Ahe acdlhtoim ngth
Aibn the dunatien Ahhlucabn.
3.INIIAL CONTACTTME
ruLLeachoAue
AWngh imcAARDR MA_ he
CAnact um AnANLAALR Mmuliak
4
4 SELECTION OF_IHE MODEL SUBSTRATE
SURFACE
h e hhamcllyng&Tw/mndc
Aitqical
Ka wng Aulnalks cuNMg tha
uCBOdhLAUNeA
Ameand ac
5 SWELL ING
n
adAMOAAL m Aling ie Te0 gaent
eadhoosen SCCuso
CC yeislegical Vualte
 elass

MUCIN TURNOVER
luceadhenue are de-
Kachud Lem_th Awf-e Ae te mLcln

ucin uwuno ulte Un

Qulelanlal mnt 0Avlule mucn
meleculbe hiu melecúlte intwLad with
muceadheane 2 Ths_hnn ALhance
teintoiOA JÄth thimuwcuk lauyet, whuch_
e wn LalNa L¢mLUcELdhteuen

2DiGEASE STATES
hheicechumical
LehuiluLe the MLLCuA Sae kmUIn_t
chamg dulimQ diaLaAL COndluem2

+ADVNANTAGES
1eleng thu uLgonc ume ehe
mAt tho RL alneutisnheNca
mcAAA0A Ahe LMOOÁLLalrlty
2 culimt accolity , apid enat o

3 Kahid aloeytien ItcanMAL OLm&ymoue

HOOd Authly Aund gs0d. loed Uo

Lg e helLclidem diqIAdatien in
Ahacidic Anment i n TYi GAT
 a admmiatalien. eassate

o. heue haveiu nyilom

a duug2 Dahe
Poge

alhehen.
5 dmhed hationt cembluanca
6 agding eh dug and Localigauen
Mymatiicacnuty amd AOLole
t tda mital-eluem
b gn daug Nux At the awin4
H DISADVANTAGES
1 MDDS QL,Lee iughttyadhured
TA mre the emulaluen
t nAAR,AlAe the huC&aa LAuld le

2 em haliwnte Au nhloaoamb
limg

4 ocicatiene Admumaliod ally d

e t snluL,thu eed nam
Wmmudiakily PU h0ARaGethMough
5 Dceuruma ecalAlayeuA c
doung hmawutg lceRgmic pahets
 elAsSMAte
Date
Page

6hack a Gecl medee inmtre

RNOOMinAto idlemlu ugs Autal
Ack Acmunialtklen

atimg Rdinkimg ua hrnehiuund.

#TRANSMUCO SA PER MEATION

twred dhauma
hantiele

MuCe
Layez

ucewe
mwmbn
 Date
Page

uaien tucora
mUmame

CXhudadAathay
Ya e Paaallulan nout

C0ong haa) CKicahtenLhheae

n dug hImealLen cheog Cchuhelial
mumAmia
CDtu uamaclulan oui
CiDthe haracelulh nout
mumlrano ConguAT ehithelual
uhotdao
athuway.
Akim &Galmura a
AnAich Ahe
Adrug dvmwnid
hnikmColCumA Andmoluela
puALen
atier Ca sugh
IHcho A
TOmomombvone hOUmaaNLAn
 tudebule Cemoumol, Auch a Abmhuurd
dtult
cetlntumeyaume. u mucillylar eh
doug anehit.
u g meiKment n thie PSte CJh) n
A Cuutwn e
J D CH-
hH
Auas AHLA
hanacl0ld ucta
h4Ehatn kimgth
C4 AEMET AdecLLG CEnc

Hanocllulah neute ie ahhliealke ez

Juhephiuc Cemneumd.ug mslLcule mee
ACA th lijehhulic C mUmlpame
oumaall aho
fhiie Cemhaund A0 the 4hinelnat
Muma/ne je , yhically high ug ur

J = CL-ES DL K,CL

9eicor
ath ength
 Page

mcenalhumLaLLen
megeAlBN
lgmumed y Jueting
Mllculo
h e Medel ihehilie
melucule AUmg m u c o L a k m u m l b n e

enald
B hhehhuc. 2hudnshhil drug
KO cahalle ehhiaWng thn0uC
al omaCMal MomlameQ
ed Rmulce.
aaakmucwa Ahoun ALgruLCgnitl
highn fate homiatienAUndad
t Lag umi th0N LCLakAUnd
CLOinalK mLSAAO
AhedutatLen Xagma ag
Nasal 2 Ructal 2Vagmak
Jugal
al mcA
umiame hickhe@
buccal
ul ungual
NaAal
535wm
753wm
Nagimal
I65.1m
 elasSMAe
Date
Page

Pumiatuen Ynhaneuz
PomLaten onhanciio Aa addod t g

Bisaailalulit

CCUmane mLAlL`n
mhamcy cy dehnta mhen
DPhyoicechumcalhnehvte Anug
Cl1d AdmumealLen Ait
Co NaÜLhe 0 ALcl
ci) mmaluc o H y
(ysih Cermheulien
(VIDYentiolngtimantochin
CUID omlyama huckneo
CIX)MA mhanCIHMlsmo_ im (Embnal+èra
t amoqle mhanLHa =
aBullAdla 2 thn unedal agente
C( Aedjuwm glycechslate
U cdium TusechAlale
Cii aenUne
CIVDediwm Qusno dudnaiueLdae

5)unhoactante
NONONIC
i PyePdate 80

CATIONIC
CID ulhy Divmihylammeniutm ltomic
ANIONIC
Ci Seciuum aueul ulhate
OTHER ENHANCERS
CI AenL
ClIDaucyati
CiiD Sudidoe
BUCCAL DELINER S/STEMS
Selid dsengu erma e etal maucecal
uLccal dililun am eclaeehiicl
ncc Ae hu (melildty m ihe a l
COtuy
Auhically tuouhea oAUAUmA2
A Ncmattochud or melule ASLLd crall A
deeagem that weuld le hhyaicol
mainidmed thm hi Aral Lanntig
in Centaci h LhemiuLEal
AUace aCenaCLA
hallunt CanenmienalMILA nd
Qaat deeslning allta eleng To

B tacha Ammmoiulizud dhug

delutuy Ay me that
canle
etaukudGnthe MuLCCAA ANtaa
y theAdheavue
ehlle the
 asSt
Dats
Pags

Ayelim i l a l .
ADVANTAGES *
apyage em And thi muuLei
CIDigh Cug_C8ncCam H manlaned at
AhAMEHIUe Aaco A Þ2ELANLOdL
hied e wme
Cii a g eum can Ammlnlized ahecicoll
prtLhyt Al muCANA.
civ Systotn laelCam peLstLct _tku ARugEm
ANhemmomiAl CUgiadalien
hollousing
diwnt eLMMuLAal uLcal ddage
meha LduniiylA -
HOLLON ELBRES
hellsu
dgnid te le Lowd im hu aty
ccal Caunay
er holenqud dug delwsuy.
CshLLA hALu qultia chelyaulhhone
An LHRH AENIAk
2 MUCO-/BIo-ADHESINE TABLETS,
tMm o-
Adhoine diocN matiLale That Lind e
nAh te lsislegical AuNLaL
ucachtune
a m ued te drecbe mallLale That
AuatL h l Ahe oum yen.dhidie
Umhlue adhuiien te coWe
 bAeadheeine aluta arImmle
ed CR dnugLdllnsu u ma
unch CmAit msnaT
Cenod 9 mulilayedmabucia
hGlleecoelhua HPC OCe
helymtQchtean AGcumAQna
o gh'Mw helyoueihylengcial
ANm.eat udata gh
ndnuem, Aceumance TUneLomgod
OdhoADNACalte
muaiten
nouude -
ack ulty dRAOLGL0m
ult Leachde igh dtuuA
AEmeCLOR

hulauluf
Aeucdu

uning
uceaclhORNO
DDS
 elAsSAe
Date
Page

netouunt
Ca)
Ttadn IIA b)
O OO BLendlhwaine

Kain
(Z7ZLZZLUILIA mhvomialle
OOj O,o VackImg
Kierdhewine
Natmh-
muva Vcickm

Ce o o cf
HHHTHH
CRmabu+

BieddhAUNR
3FILMSANDPATCHES
>Backima
oOOo0 dnug Eoooooi
Mucenal mumliane
2 h ALyaume ha een dovelshua ko cod
eme 1 doautrnckke of muCeadhiae tallte
achu 00 MALLally uhaHLd ly a n g a
And

Winm it tedy
ala Mauallybmade o ana -30m
w u Am elihese ahahe Z tcemEUalH
 eiASSAT
Date
Page

Jnts theLnA d tu JaiLeak mucea

A t hlymer&Caml ANALCL e2
duelsumimt dnug 9aoeot
mucendhere atchee Jnlucima
ClulSAO dHUNatime Matunal ome
And pelumetnacyla
Rahdutmuceadhuguehohehtiea
Ance Aaluita
h AAhiuue h a t cha yaimCam
QUnhle OdhANe
dg-eaded mgtAohiaine Laen n

CHEING CaUM
adicozd chisimq uiUm
4ility to utgum tin Yo tal cat
Leng hnLede yeielenged Awo
dopirALY
AAAt emAt tim o

al muceaa
C Abty kodolmwny
dnugs te Tha GT 4
9duc 11utotuertto
civ) aRy 1eAmChPctN rAomwch
AuL& mamuctn
9ALm ae, mulaiuS
amuexiCanta
taaTOmiA-
 alAsstee

lacc Laml ChLng gm e

muceumi CNLcSUeQum)._

5 QULDCRISIALLINE PHASESOE CGLYCERL

MONO-OLEATE GMOD
GaMOS ManD -olun
e helan_hid_CEmhpd MenD
Gycudoe omamly eluciacid Amd
ofha CCi hen CEmtact t h
Late it hwella e eum d mi Tyre
cueShic auLd ualalun_hhaste
PRoPER TIES x_
Ca)ucOachiAiwe hhHty
( A y te umcCeLhsuot eth hydehhiluc
hshlue ugs
Lecemhailultu
cd) Yretdiw cdden Agaun maymatLe
dgacatyen ARCUuGIYynd
agaunat chomLCal imalaHLUL A Augz

CMO Cam cltud_thngugh hi 1al

mcea ith thaohUlLe Lacy
6SEMLSOLIDS1ELS,
Centan a id
adhooehelymi Amd deug hlua Any
uguicd iaduont dieosed SNAehimled
hqucuAan
hy cam ahkld
MAmg th nge JAA TAgai P0Aien
MICRO PARTIC LESJcheralicdoooh2
mo adwantagee, ush e
hhyicechemlcal chanadllill
i
CO main maltLOA GE
C Ahuy CAn e Admumattuk y

CCS y u c t Omcaheulaid dnug

Cd)
CeduyCam An devmulatid touencla
COnltamt catug Cene: in heLed
uat ecal duwaut.
hy Cam e
h a e ly-
CiD o m-elaim Col0mhed)
CI atuin-oiln-Mialitdsule emuloien
Comdhed N

1nacune
8LECTINS
hnolum Mat Iina te shao Au
NALdue4AmdiCAm
MMcUowng