METRONI

DAZOLE
 Met
roni
dazol
e
(1-
[2-
hydr
oxyethy
l]
-2-
met
hyl
-5-
nit
roi
midazol
e)
i
sani tr
oimidazoledrugactiveagainst
anaerobicbacter
iaandcer tainpar
asit
esIti
sa
widel
yuseddr uggiveni t
stolerabi
li
ty,
highoral
bi
oavailabi
li
tyandcapaci t
yt openetr
ateint
o
ti
ssueswel l
,i
ncludi
ngt he(CNS)

Sour
ceofMet
roni
dazol
e
Met roni
dazoleisasy ntheticant i
bioti
cand
antiprot
ozoalmedi cati
on.I ti
snotder i
vedfrom
plants.Thedrugwasf i
rstsy nthesizedinthe
1960sandhassi ncebeenwi delyusedt otr
eat
vari
ousbact eri
alandpar asit
icinfecti
ons.Whi l
e
therearenaturalantibi
ot i
csder ivedfrom plant
s,
met roni
dazoleisspecificall
ycr eatedthrough
chemi calsy
nthesis.
 Met
roni
dazol
edi
scov
ery
byscienti
stsatt
hepharmaceuti
calcompany
Rhône-Poul
encinFr
anceinthe1950s.Itwas
i
niti
all
ydevel
opedasananti
parasit
icagentf
or
thetr
eatmentofTri
chomonasvaginal
is
i
nfect
ions.
Thecompoundexhi bit
edantimicr
obi
al
propert
iesbeyondit
sorigi
nalscope,
showi
ng
effect
ivenessagai
nstcert
ainbact
eri
a.
Thedi scoveryofmet r
onidazol e'
sbr oader
spect rum ofact i
vi
ty,i
ncludingi t
sef f
icacy
agai nstanaer obi
cbacteria,ledtoi t
susei n
treatingv ar
iousbacterialandpr otozoal
i
nf ections.Thedr ug'
sabi l
itytoselectively
targetanaer obicorganisms, whi chthri
v einlow-
oxy genenv ironments,contributedtoi t
s
successi ntreati
ngcondi t
ionssuchascer tai
n
bact eriali
nfecti
onsandamoebi cdiseases.
 Metroni
dazol
e'
sdev
elopmentand
subsequent
recogniti
onforitstherapeut i
cpotenti
al
highli
ghttheserendipitousnat ur
eofdrug
discovery,whereinit
ialresearchforone
purposecanl eadt othei denti
fi
cati
onof
unex pect
edappl i
cations.
Massspect
rum
I
ROFMETRONI
DAZOLE
NMROFMETRONI
DAZOLE
NMROFMETRONI
DAZOLE
Doneby\Ebr
ahi
m Khal
i
lAl
j
aber
i
Ramzi
Almasqr
i

DR\Abdul
l
ahSal
eh