Predisposing factors

Precipitating Factors -Cancer (Colorectal cancer 16.2%)

-Diet rich in fatty -Older adults (slower motility, decreasing muscle tone)
-Tumor (Physical, blood flow impairment)

Affects normal cells

Mutation in DNA mismatch Proto-oncogenes transforms to

repair genes oncogenes

Inability to control
Promote formation of cancer cells and
proliferation of affected cells.
deactivate tumor suppressor genes

Neoplasm formation in rectum WBC-1/22/24

and sigmoid colon 11.91 X10^3mm3

DNA repair genes inactivated. Electrolyte Panel Test- 2/2/24

Potassium- 2.07

Increase survival and

proliferation of cancer cells.

Invades the intestinal tract Orange box- Laboratory and Diagnostic test
Green box- Surgical Management
Yellow box – Nursing Care Plans
Blue box- Pharmacologic Management
Line without arrow- not in sequence.
Invades epithelium in the Line with arrow- sequence
bowel wall.

Mucosa in the large intestine.

(Regeneration of Abnormal
cells)

Undergoes
differentiation
and maturation COLONSCOPIC BIOPSY-
1/11/24
Impression: COLORECTAL
villous adenoma CANCER-
Histopathologic diagnosis: at
least villus adenoma with high
grade dysplasia in a
background of extensive
necrosis.
Additional mutations accumulate affecting
genes that control cell cycle, apoptosis
(programmed cell death)

progressive cellular Tranexamic Acid 500 mg IVTT every 8 hrs.

abnormalities (resembling Vitamin K 1amp. IVTT every 8 hrs.
cancer cells but still confined to Omeprazole 40 mg. IVTT OD (+) Increased
the inner lining (epithelium). Cefuroxime 750 mg IVTT every 8 hrs. NCP peristalsis attempts
Metronidazole 600 mg IVTT every 6 hours #1,2,3 to force contents
past obstruction.
Additional mutations accumulate,
affecting genes that control cell cycle,
Exploratory Laparoscopy, Anterior
apoptosis and other critical cellular
Resection Hartmann’s procedure,
processes
Colostomy
-Abdominal pain and cramping
Contrast CT Scan: 1/22/24 pain scale of 10/10.
8.1 mass with exophytic: component- Colorectal Partial Mechanical Bowel Obstruction
-Severe nausea and vomiting
Cancer -Loss of appetite