Professional Documents
Culture Documents
KENNETH S. SALADIN
Distinguished Professor of Biology, Emeritus
Georgia College
Digital Authors
CHRISTINA A. GAN
Highline College
HEATHER N. CUSHMAN
Tacoma Community College
ANATOMY & PHYSIOLOGY: THE UNITY OF FORM AND FUNCTION, NINTH EDITION
Published by McGraw-Hill Education, 2 Penn Plaza, New York, NY 10121. Copyright ©2021 by McGraw-Hill
Education. All rights reserved. Printed in the United States of America. Previous editions ©2018, 2015, and
2012. No part of this publication may be reproduced or distributed in any form or by any means, or stored in a
database or retrieval system, without the prior written consent of McGraw-Hill Education, including, but not
limited to, in any network or other electronic storage or transmission, or broadcast for distance learning.
Some ancillaries, including electronic and print components, may not be available to customers outside the
United States.
1 2 3 4 5 6 7 8 9 LWI 24 23 22 21 20
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The Internet addresses listed in the text were accurate at the time of publication. The inclusion of a website does
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guarantee the accuracy of the information presented at these sites.
mheducation.com/highered
BRIEF CONTENTS
iii
ABOUT THE
AUTHORS
CHRISTINA A. GAN, digital coauthor for Connect®, has been teaching anatomy and physiol-
ogy, microbiology, and general biology at Highline College in Des Moines, Washington, since 2004.
Before that, she taught at Rogue Community College in Medford, Oregon, for 6 years. She earned
her M.A. in biology from Humboldt State University, researching the genetic variation of mitochon-
drial DNA in various salmonid species, and is a member of the Human Anatomy and Physiology
Society. When she is not in the classroom or developing digital media, she is climbing, mountaineer-
ing, skiing, kayaking, sailing, cycling, and mountain biking throughout the Pacific Northwest.
HEATHER N. CUSHMAN, digital coauthor for Connect®, teaches anatomy and physiology
at Tacoma Community College in Tacoma, Washington, and is a member of the Human Anatomy
and Physiology Society. She received her Ph.D. in neuroscience from the University of Minnesota
in 2002, and completed a postdoctoral fellowship at the Vollum Institute at Oregon Health & Science
University in Portland, Oregon, where she studied sensory transduction and the cellular and molec-
ular mechanisms of muscle pain. She currently resides in Tacoma, Washington, and enjoys climbing,
camping, and hiking with her husband Ken and their daughter Annika.
Ken Saladin’s first step into authoring was a 318-page paper on the ecology
of hydras written for his tenth-grade biology class. With his “first book,”
featuring 53 original India ink drawings and photomicrographs, a true story-
teller was born.
When I first became a textbook writer, I found myself bringing the same
enjoyment of writing and illustrating to this book that I first discovered
when I was 15.
—Ken Saladin
Courtesy of Ken
Saladin
viii
PREFACE
Anatomy & Physiology: The Unity of Form and Function tells a story comprised of many layers, including core science, clinical applica-
tions, the history of medicine, and the evolution of the human body. Saladin combines this humanistic perspective on anatomy and physi-
ology with vibrant photos and art to convey the beauty and excitement of the subject to beginning students.
To help students manage the tremendous amount of information in this introductory course, the narrative is broken into short seg-
ments, each framed by expected learning outcomes and self-testing review questions. This presentation strategy works as a whole to create
a more efficient and effective way for students to learn A&P.
Organizational Changes
For improved readability, narrative descriptions of some systems are moved from tables into chapter text; selected illustrations are moved
outside of the tables; and tables are distilled to more concise summaries. These include the skeletal muscles (chapter 10), spinal nerve
plexuses (chapter 13), cranial nerves (chapter 14), and blood vessels (chapter 20). A detailed list of changes by chapter follows.
ix
Detailed List of Changes
Chapter 1, Major Themes of Anatomy and Physiology, now includes digital subtraction angiography among the common clinical imag-
ing techniques.
Atlas A, General Orientation to Human Anatomy, has an added Deeper Insight A.1 on cardiac tamponade in relation to body cavities
and membranes.
Chapter 2, The Chemistry of Life, has added the Nobel-winning new technique of cryo-electron microscopic imaging of biological
structure at the atomic level.
Chapter 3, Cellular Form and Function, has enhanced discussions of limitations on cell size, the origin of peroxisomes, mitochondrial
fusion and fission, and clinical mitochondrial transfer and three-parent babies.
Chapter 4, Genes and Cellular Function, updates protein processing by the Golgi complex, epigenetics, the DNA damage response, and
the role of the nuclear lamina in gene silencing.
Chapter 5, The Human Tissues, has a new perspective on the tissue interstitium, updates on stem-cell therapy and regenerative medicine,
and a new Deeper Insight on biopsy methods.
Chapter 6, The Integumentary System, has a new drawing of epidermal histology, new discussion of the evolutionary genetics of apo-
crine glands, an update on skin-grafting technology, and a simpler description of the hair growth cycle.
Chapter 7, Bone Tissue, gives a less detailed overview of calcium and phosphate homeostasis, adds a Deeper Insight on osteomalacia
and rickets, and updates the pathology and treatment of osteoporosis.
Chapter 8, The Skeletal System, conforms the description of normal and pathological spinal curvatures to orthopedic terminology and
has a new Deeper Insight on herniated discs.
Chapter 9, Joints, improves the discussion of joint biomechanics and updates the discussions of temporomandibular joint dysfunction
and engineering of prosthetic joints.
Chapter 10, The Muscular System, pulls illustrations and narrative descriptions from the muscle tables, converts the narrative to easier-
to-read normal text, and condenses the tables to more concise summaries. It updates inguinal hernias and adds new Deeper Insights on
rotator cuff injury, shinsplints, calcaneal tendon rupture, and plantar fasciitis.
Chapter 11, Muscular Tissue, adds a photo of the histochemistry of fast glycolytic and slow oxidative muscle fiber types and updates
the discussion of fibromyalgia.
Chapter 12, Nervous Tissue, includes updates on astrocyte functions, beta-endorphin and enkephalin, mutations affecting neurotransmit-
ter reuptake and neurological disorders, and the implication of lipofuscin in some diseases. It introduces the frontier neuroscience of brain
connectomics and the use of diffusion tensor imaging to visualize the connectome. There is now an illustration of the midbrain histological
change and body posture characteristic of Parkinson disease.
Chapter 13, The Spinal Cord, Spinal Nerves, and Somatic Reflexes, adds a new Deeper Insight and illustration of lumbar puncture,
reduces detail on spinal cord tracts, reformats the tables of spinal nerve plexuses, illustrates regional innervation of the hand by the major
forearm nerves, and adds a photo of a shingles lesion.
Chapter 14, The Brain and Cranial Nerves, now adopts the concept of brainstem as excluding the diencephalon. It adds Deeper Insights
on stroke and diffusion tensor imaging, and updates the Deeper Insight on trigeminal neuralgia and Bell palsy, adding an illustration of
the latter. It updates sleep physiology and the functions of the midbrain colliculi and pretectal nuclei. It corrects a common misconception
about the subdural space. The discussion and table of cranial nerves are reorganized.
Chapter 16, Sense Organs, has an updated discussion of pain physiology and includes phantom limb pain. It updates the genetics and
functions of some taste sensations and flawed assumptions about human olfactory sensitivity. It deletes discredited or dubious views of
endorphins and runner’s high and human pheromones. It enhances the figure of olfactory projection pathways; adds the dorsal and ventral
streams of visual processing pathways; adds photos of cataracts and glaucoma; adds macular degeneration and diabetic retinopathy to the
Deeper Insight on blindness; and has better insights into the functions of the cornea, choroid, and vitreous body.
Chapter 17, The Endocrine System, updates the histology and cytology of the thyroid gland and pancreatic islets and the effects of mela-
tonin; adds new information on hormones of osseous and adipose origin; updates the enteroendocrine system; and adds effects of
lipocalin 2 on insulin action. It deletes the now-questionable idea about pineal tumors and precocial puberty. It updates the pathologies
of Addison disease and myxedema, and the genetic, immunological, and treatment aspects of diabetes mellitus.
x
Chapter 18, The Circulatory System: Blood, now explains how blood is fractionated to obtain plasma and then serum, and the uses of
blood serum. It has an enhanced explanation of the functional significance of the discoidal shape of erythrocytes, and includes cell pro-
liferation in the illustration of erythropoiesis. It reports updated clinical research on the number of known blood groups and RBC antigens,
cord blood transplants, other methods of bone marrow replacement, and pharmaceutical anticoagulants. It adds the surprising new discov-
ery of abundant platelet production by megakaryocytes in the lungs and megakaryocyte migration between the lungs and bone marrow.
Chapter 19, The Circulatory System: Heart, is reorganized at section 19.1 to place figures closer to their references. Cardiac innervation
is moved to section 19.6 on regulation of cardiac output, with a new illustration. The electrocardiogram is described with more detailed
attention to interpretation of each wave, segment, and interval, with an added table. The section on cardiac arrhythmias includes a fuller
explanation of atrial fibrillation.
Chapter 20, The Circulatory System: Blood Vessels and Circulation, has improved discussions of the vasa vasorum and metarterioles;
describes the measurement of blood pressure in more depth; adds photos of edema, circulatory shock, and upper limb veins most often
used for phlebotomy; and has a new drawing of air embolism. It discusses the difficulty of pancreatic surgery in light of the complex, deli-
cate branches of the celiac trunk. The Deeper Insight on ascites is rewritten to relate it to alcoholism. The tables of blood vessels and
routes of flow are now converted to normal, easier-to-read text.
Chapter 21, The Lymphatic and Immune Systems, updates bone marrow histology; the sources of macrophages; T cell diversity;
asthma and AIDS mortality; and the obstacles to treating AIDS in pandemic countries. It adds the risk in splenectomy and the role of ATP
and ADP as inflammatory chemoattractants.
Chapter 22, The Respiratory System, enhances descriptions of the nasal epithelium; the cricothyroid ligament in relation to emergency
tracheotomy; the Deeper Insight on tracheotomy; cor pulmonale; and squamous cell carcinoma. It adds a mutational cause of Ondine’s
curse; discovery of pulmonary platelet production; and the potential of electronic cigarettes and legalization of recreational marijuana as
emerging risk factors for lung cancer.
Chapter 23, The Urinary System, adds to the function of glomerular mesangial cells and has an improved Deeper Insight on kidney
stones, with a new photo.
Chapter 24, Fluid, Electrolyte, and Acid–Base Balance, has further information on sodium and the effects of hypernatremia, and has
added a new table summarizing the major electrolyte imbalances.
Chapter 25, The Digestive System, includes additions on the immune role of the omenta; dental proprioception; aspirin and peptic ulcer;
the cell-signaling function of the intestinal mucous coat; anatomical variability of the colon and a new drawing of its histology; an updated
Deeper Insight on gallstones, with a photo; a new Deeper Insight on diverticulosis and diverticulitis; a new Deeper Insight on colorectal
cancer; and an improved description of intestinal lymphatic nodules.
Chapter 26, Nutrition and Metabolism, includes new MRI images of a morbidly obese individual compared to one of normal BMI; a
new drawing of lipoprotein structure and chart of composition of the lipoprotein classes; new information on the effects of leptin on sym-
pathetic nerve fibers and lipolysis; and a new photo of hepatic cirrhosis.
Chapter 27, The Male Reproductive System, has a new table and discussion of the composition of semen and function of the bulboure-
thral preejaculatory fluid, and updates on benign prostatic hyperplasia and prostate cancer. It adds discussion of zinc deficiency as a cause
of infertility, hypothalamic maturation and GnRH in relation to the onset of puberty, and andropause in relation to declining androgen
secretion.
Chapter 28, The Female Reproductive System, has improvements in hymen anatomy and the figure of ovarian structure; a new perspec-
tive on morning sickness as a possible factor mitigating birth defects; and updates on contraception and on breast cancer genes, risk fac-
tors, and mortality.
Chapter 29, Human Development and Aging, adds the role of the sperm centrosome in fertilization; chromosomal defects as a leading
cause of first-trimester miscarriages; and the formation of monozygotic twins. It adds a new Deeper Insight and illustration of cleft lip
and palate. It updates the telomere theory of senescence but deletes the now-doubtful theory of DNA damage by endogenous free radicals.
It adds a new, MRI-based drawing of muscle atrophy in old age and a discussion of pineal gland senescence as a factor in the insomnia
experienced by some older people. It updates statistics on human life expectancy and the major causes of death. The final Deeper Insight
is retitled Assisted Reproductive Technology and has a new photo of intracytoplasmic sperm injection.
Appendix D, The Genetic Code and Amino Acids, now adds a table of the 20 amino acids and their symbols, and the structural formulae
of the amino acids.
xi
ACKNOWLEDGMENTS Valerie Kramer, Marketing Manager;
Donna Nemmers, Senior Product Devel-
Kyle P. Harris
Temple University
Peer review is a critical part of the scientific oper; Vicki Krug, Senior Content Project Karen L. Kandl
process, and very important to ensure the Manager; Lori Hancock, Lead Content Western Carolina University
content in this book continues to meet the Licensing Specialist; Brent dela Cruz, Stephen A. Kash
needs of the instructors and students who Senior Content Project Manager; Egzon Oklahoma City Community College
use it. We are grateful for the people who Shaqiri, Designer; and Jeanne Patterson, Stephanie Matlock
agree to participate in this process and thank freelance copy editor. Their efforts have Colorado Mesa University
them for their time, talents, and feedback. yielded another great edition of the text Deborah T. Palatinus
The reviewers of this text (listed here) have and its companion media suite of Connect Roane State Community College
contributed significant comments that help products. Jeffrey Alan Pence
us refine and update the print and digital Excelsior College
components of this program.
Timothy A. Ballard Carla Perry
Christina Gan and Heather Cushman University of North Carolina—Wilmington Community College of Philadelphia
have updated the question bank and test
Barry N. Bates Franz Sainvil
bank to closely correlate with the intricate
Atlanta Technical College Broward College–Central Campus
changes made in this ninth edition and
Christopher I. Brandon Jr. Brian Stout
have greatly increased the educational
Georgia Gwinnett College Northwest Vista College
value of these books through their work to
create self-assessment tools and align Nickolas A. Butkevich Andrew Van Nguyen
Schoolcraft College The City University of New York–
McGraw-Hill’s Connect resources with
the textbook. This has contributed signifi- John W. Campbell Queensborough Community College
cantly to student and instructor satisfac- Oklahoma City Community College Kimberly Vietti
tion with our overall package of learning Jennifer Cochran Biederman Illinois Central College
media and to the students’ success as they Winona State University Beth L. Williams
master A&P en route to their career Mary B. Colon Wallace State Community College
aspirations. Seminole State College of Florida Delon Washo-Krupps
I would also like to extend apprecia- Abdeslem El Idrissi Arizona State University
tion to members of the Life Sciences Book College of Staten Island, City University Samia Williams
Team at McGraw-Hill Education who have of New York Santa Fe College
worked with me on this project, including Bagie George
Matthew Garcia, Senior Portfolio Manager; Georgia Gwinnett College
xii
THE STORY OF
FORM AND FUNCTION
BRIEF CONTENTS
13 The Spinal Cord, Spinal Nerves, and APPENDIX E: Medical Word Roots and Affixes A-19
muscle and nerve cells is treated Somatic Reflexes 459
in two consecutive chapters (11 14 The Brain and Cranial Nerves 492
Glossary G-1
Index I-1
and 12), which are thus closely 15 The Autonomic Nervous System and
Visceral Reflexes 542
integrated in their treatment of 16 Sense Organs 563
synapses, neurotransmitters, and 17 The Endocrine System 612
xiii
THE STORY OF
FORM AND FUNCTION
LEARNING TOOLS
Engaging Chapter Layouts
∙∙ Chapters are structured around the way students learn.
CHAPTER
∙∙ Frequent subheadings and expected learning outcomes help
students plan their study time and review strategies.
BONE TISSUE
Deeper Insights highlight areas of interest
and career relevance for students.
1
3
cub = cube; oidal = like, resembling
4
poly = many; gon = angles
5
when teaching chapters out of order.
cyto = cell; logy = study of stell = star; ate = resembling, characterized by
xiv
CHAPTER 9 Joints 271
separation between the bones and length of the fibers give these (fig. 9.4a). (The other costal cartilages are joined to the sternum by
joints more mobility than a suture or gomphosis has. An especially synovial joints.)
mobile syndesmosis exists between the shafts of the radius and
ulna, which are joined by a broad fibrous interosseous membrane. Symphyses
This permits such movements as pronation and supination of the
In a symphysis9 (SIM-fih-sis), two bones are joined by fibrocarti-
forearm. A less mobile syndesmosis is the one that binds the distal
Questions in figure legends and Apply What You ends of the tibia and fibula together, side by side (see fig. 9.2c).
lage (fig. 9.4b, c). One example is the pubic symphysis, in which
the right and left pubic bones are joined anteriorly by the carti-
Know items prompt students to think more deeply 9.1c Cartilaginous Joints
laginous interpubic disc. Another is the joint between the bodies
of two vertebrae, united by an intervertebral disc. The surface of
about the implications and applications of what they A cartilaginous joint is also called an amphiarthrosis7 (AM-fee-
ar-THRO-sis). In these joints, two bones are linked by cartilage
each vertebral body is covered with hyaline cartilage. Between the
vertebrae, this cartilage becomes infiltrated with collagen bundles
to form fibrocartilage. Each intervertebral disc permits only slight
have learned. This helps students practice higher (fig. 9.4). The two types of cartilaginous joints are synchondroses
and symphyses. movement between adjacent vertebrae, but the collective effect of
all 23 discs gives the spine considerable flexibility.
order thinking skills throughout the chapter. Synchondroses
A synchondrosis8 (SIN-con-DRO-sis) is a joint in which the ▶▶▶APP LY W HAT YO U K NOW
bones are bound by hyaline cartilage. An example is the temporary The intervertebral joints are symphyses only in the cervi-
joint between the epiphysis and diaphysis of a long bone in a child, cal through the lumbar region. How would you classify
formed by the cartilage of the epiphysial plate. Another is the at- the intervertebral joints of the sacrum and coccyx in a
tachment of the first rib to the sternum by a hyaline costal cartilage middle-aged adult?
7
amphi = on all sides; arthr = joined; osis = condition
8 9
syn = together; chondr = cartilage; osis = condition sym = together; physis = growth
Clavicle Sternum
Rib 1
Intervertebral
Costal disc (fibrocartilage)
cartilage
ST U DY
(a) G U I DE
▶ Assess Your Learning Outcomes
(c) extension, hyperexten- Body of vertebra
To test your knowledge, discuss the following 3. Three essential components of a lever 12. The same for flexion,
FIGURE
topics 9.4partner
with a study or in writing,Joints.
Cartilaginous ideally 4. The meaning of mechanical advantage (MA); sion, and lateral flexion of the spine, and
from(a)
memory.
A synchondrosis, represented by how the MA of a lever can be determined right and left rotation of the trunk
from measurements of its effort and resis- 13. The same for elevation, depression, protrac-
9.1 the costal
Joints andcartilage joining rib 1 to the
Their Classification tance arms; and the respective advantages of tion, retraction, and lateral and medial excur-
sternum. (b) The pubic symphysis.
1. The fundamental definition of joint (articu- levers in which the MA is greater than or less sion of the mandible
(c) Intervertebral discs, which join
lation) and why it cannot be defined as a than 1.0 14. The same for dorsiflexion, plantar flexion,
adjacent vertebrae to each other by
point at which one bone moves relative to an 5. Comparison of first-, second-, and third-class inversion, eversion, pronation, and supina-
symphyses. Interpubic disc
adjacent bone levers, and anatomical examples of each tion of the foot
2. ? What is the
Relationships and difference
differences betweenbetween the 6. Variables that determine a joint’s range of (fibrocartilage)
9.3 Anatomy of Selected CHAPTER 9 Joints
Diarthroses 297
the pubic
sciences symphysis
of arthrology, and the
kinesiology, and motion (ROM), and the clinical relevance
Pubic symphysis
interpubic disc?
biomechanics of ROM (b) 1. Features of the jaw (temporomandibular)
3. The typical system for naming most joints 7. Axes of rotation and degrees of freedom in joint including the mandibular condyle,
ST U DY
after the bones they involve; examples of joint movement, and how this relates to the mandibular fossa, synovial cavity, articular
296 PART thisTWO Support and Movement
4. Basic criteria for classifying joints G U I DE classification of joints as monaxial, biaxial,
or multiaxial
disc, and principal ligaments
2. Features of the shoulder (glenohumeral)
5. Characteristics and examples of bony joints 8. Six kinds of synovial joints; how each is joint including the humeral head, glenoid
(synostoses) classified as monaxial, biaxial, or multiaxial; cavity and labrum, five major ligaments
ST U DY 4. Whichofoffibrous
6. Characteristics the following joints cannot be
joints (synar- imperfectionsd. always
in this produces
classification;an MA andless than 1.0. and four 12.bursae,
A fluid-filled
and tendons sac that eases
of the the movement
biceps
The end-of-chapter Study Guide offers several methods throses) and G U I DE
circumducted?
each of their subclasses, with
examples a. carpometacarpal
examples of e. each
9. The concept of
is applied
move
type inonthe
zeroaposition
one
resistance
bodyside of the fulcrum to brachii andoffour
andonhowtheitother side. 3. Features of the elbow;
a tendon
rotatorover
.
cuffa muscles
bone is called a/an
the three joints that
7. Characteristics of cartilaginous joints (am- relates to the description of joint function occur here; the olecranon bursa and four
Bloom’s Taxonomy in sections to phiarthroses) and each of their subclasses,
with examples
10. Examples of each of the following limb
movements, including an ability to
major ligaments
4. Features of the hip (coxal) joint including
▶ Building Your Medical Vocabulary Answers in Appendix A
1. test simple recall and analytical thought; 9.2 Synovial Joints
describe or demonstrate them: flexion,
extension, hyperextension, abduction,
the femoral head, fovea capitis, acetabulum
and labrum, and five principal ligaments
1. The definition and State a meaning
anatomical of eachofword
features a element, 3. -ate hyperadduction,
and give hyperabduction,
adduction, 5. Features of the knee 7. (tibiofemoral
kinesio- and
2. build medical vocabulary; and a medical term
synovial joint (diarthrosis),
type, and why this slight
typevariation
from this
examples chapter thatcircumduction,
of this
of it. interest
is of greatest
uses it or a
rotation
medial rotation, and lateral
4. cruci- patellofemoral joints),8. men- including the menisci,
cruciate and other ligaments, and four major
5. cruro- 9. supin-
3. apply the basic knowledge to new clinical for kinesiology 1. ab-
2. General anatomy of tendons, ligaments,
11. The same for supination,
flexion, and radial 6. flexion
-duc
pronation, ulnar
of the forearm 6.
bursae around the patella
Features of the ankle (talocrural)
10. -trac joint,
bursae, and tendon2.sheaths,
arthro-and their contri- and hand, and opposition, reposition, abduc- including the malleoli, calcaneal tendon, and
problems and other situations. butions to joint function tion, and adduction of the thumb major ligaments
▶ Testing Briefly
Yourexplain
Recall 4. Menisci occur in the elbow and knee joints. Answers in Appendix
8. The knuckles A
are amphiarthroses.
What’s Wrong with These Statements? questions
why each of the following state-
ments is false, or reword it to make it true.
5. Reaching behind you to take something out 9. Synovial fluid is secreted by the bursae.
1. Internal and external rotation of the 2. Which of the following is the least mov- 3. Which of the following movements are
1. More people get rheumatoid arthritis than of your hip pocket involves flexion of the
further address Bloom’s Taxonomy by asking humerus is made possible by a
a. pivot
osteoarthritis.
joint. able?
a. a diarthrosis
shoulder.
10. Like most ligaments, the periodontal liga-
unique to the foot?
ments attach one bone (the tooth) to another
a. dorsiflexion and inversion
b. condylar 2. A doctor who treats arthritis is called a
b. a synostosis 6. The cruciate ligaments are in theb.feet. (the mandible or maxilla).
elevation and depression
the student to explain why the false statements c. ball-and-socket kinesiologist.
d. saddle
c. a symphysis c. circumduction and rotation
7. The femur is held tightly in the acetabulum
d. a synovial joint d. abduction and adduction
3. Synovial joints are also known as mainly by the round ligament.
are untrue. e. hinge
298 e. a condylar joint
synarthroses. PART TWO Support and Movement
e. opposition and reposition
STUDY
Testing Your Comprehension questions address GUIDE
Bloom’s Taxonomy in going beyond recall to
▶ Testing Your Comprehension
application of ideas. 1. All second-class levers produce a mechani- the first interphalangeal joint of the index arm. Imagine a person holding a weight
cal advantage greater than 1.0 and all third- finger. (Do not bend the fingers of a wired in the hand and abducting the arm. On a
class levers produce a mechanical advantage laboratory skeletal hand, because they can laboratory skeleton, identify the fulcrum;
less than 1.0. Explain why. break off.) measure the effort arm and resistance arm;
determine the mechanical advantage of
2. For each of the following joint movements, 3. In order of occurrence, list the joint actions
this movement; and determine which of
state what bone the axis of rotation passes (flexion, pronation, etc.) and the joints
the three lever types the upper limb acts as
through and which of the three anatomical where they would occur as you (a) sit
when performing this movement.
planes contains the axis of rotation. You down at a table, (b) reach out and pick
may find it helpful to produce some of up an apple, (c) take a bite, and (d) chew 5. List the six types of synovial joints, and for
these actions on an articulated laboratory it. Assume that you start in anatomical each one, if possible, identify a joint in the
skeleton so you can more easily visualize position. upper limb and a joint in the lower limb that
the axis of rotation. (a) Plantar flexion; fall into each category. Which of these six
4. The deltoid muscle inserts on the deltoid
(b) flexion of the hip; (c) adbuction of the joints has/have no examples in the lower
tuberosity of the humerus and abducts the
thigh; (d) flexion of the knee; (e) flexion of limb?
xv
THE STORY OF
FORM AND FUNCTION
Medullary cords
LEARNING
Reticular tissue
Macrophage
Trabecula
Trabecula
The incredible art program in this textbook sets the standard Lymphocytes
in A&P. The stunning portfolio of art and photos was created Cortex: Reticular fibers
Subcapsular sinus
with the aid of art focus groups and with feedback from Lymphatic nodule Artery
and vein
Venule
Germinal center
hundreds of accuracy reviews. Cortical sinuses
(b)
Medulla:
Medullary sinus Efferent
lymphatic Lymphocytes
Medullary cord
vessel
Reticular fibers
Frontal sinus
Cribriform plate
Nasal conchae: Auditory tube
Superior
Middle Sites of respiratory control nuclei:
Inferior Pons
Medulla oblongata
Meatuses
Nasopharynx
Hard palate Uvula
Oropharynx
Tongue
Laryngopharynx
Larynx:
Epiglottis
Vestibular fold
Vocal cord
Trachea
Vertebral column
Cadaver dissections are paired with
Esophagus
carefully drawn illustrations to show
(a) intricate human detail.
Rebecca Gray/McGraw-Hill Education
Meatuses:
Frontal Superior
sinus Middle
Nasal conchae: Inferior
Superior Sphenoidal sinus
Middle Posterior nasal
aperture
Inferior Pharyngeal
Vestibule tonsil
Guard hairs Auditory Nasal septum:
tube
Naris (nostril) Perpendicular plate
Hard palate Soft palate
Upper lip Uvula Septal cartilage
Oropharynx
Vocal cord
Larynx
Trachea
Esophagus
(b) (c)
xvi
Palmaris longus tendon (cut) Flexor digitorum superficialis
tendon
Orientation Tools Flexor carpi radialis tendon Flexor digitorum profundus
tendon
Saladin art integrates Flexor carpi ulnaris tendon
Flexor pollicis longus tendon
tools to help students Ulnar artery
quickly orient themselves Palmar carpal ligament (cut)
Ulnar nerve
within a figure and make
Radial artery
connections between ideas. Flexor retinaculum covering
carpal tunnel
Median nerve
Bursa
Palmaris longus
tendon Median nerve
Thenar muscles Ulnar artery
Flexor digitorum Flexor retinaculum
superficialis tendons
Carpal tunnel
Trapezium
Flexor digitorum Hypothenar muscles
profundus tendons
Ulnar bursa
Radial artery
Anterior Hamate
Trapezoid
Capitate
Lateral Medial
Scaphoid Extensor tendons
Posterior
(b) Cross section
Process Figures
Conducive to Learning Saladin breaks complicated physiological
∙∙ Easy-to-understand process figures processes into numbered steps for a
∙∙ Tools for students to easily orient themselves manageable introduction to difficult
concepts.
10
1 Blood enters right atrium from superior
and inferior venae cavae.
xvii
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W
hen I was a young boy, I became interested in what I pedagogy—the art of teaching. I’ve designed my chapters to make
then called “nature study” for two reasons. One was the them easier for you to study and to give you abundant opportunity
sheer beauty of nature. I reveled in children’s books to check whether you’ve understood what you read—to test your-
with abundant, colorful drawings and photographs of animals, self (as I advise my own students) before the instructor tests you.
plants, minerals, and gems. It was this esthetic appreciation of Each chapter is broken down into short, digestible bits with a
nature that made me want to learn more about it and made me hap- set of Expected Learning Outcomes at the beginning of each sec-
pily surprised to discover I could make a career of it. At a slightly tion, and self-testing questions (Before You Go On) just a few
later age, another thing that drew me still deeper into biology was pages later. Even if you have just 30 minutes to read during a lunch
to discover writers who had a way with words—who could capti- break or a bus ride, you can easily read or review one of these brief
vate my imagination and curiosity with their elegant prose. Once I sections. There are also numerous self-testing questions in a Study
was old enough to hold part-time jobs, I began buying zoology and Guide at the end of each chapter, in some of the figure legends, and
anatomy books that mesmerized me with their gracefulness of the occasional Apply What You Know questions dispersed
writing and fascinating art and photography. I wanted to write and throughout each chapter. The questions cover a broad range of
draw like that myself, and I began teaching myself by learning cognitive skills, from simple recall of a term to your ability to
from “the masters.” I spent many late nights in my room peering evaluate, analyze, and apply what you’ve learned to new clinical
into my microscope and jars of pond water, typing page after page situations or other problems. In this era of digital publishing, how-
of manuscript, and trying pen and ink as an art medium. My “first ever, learning aids go far beyond what I write into the book itself.
book” was a 318-page paper on some little pond animals called SmartBook®, available on smartphones and tablets, includes all of
hydras, with 53 India ink illustrations that I wrote for my tenth- the book’s contents plus adaptive technology that can give you
grade biology class when I was 16 (see page viii). personalized instruction, target the unique gaps in your knowledge,
Fast-forward about 30 years, to when I became a textbook and guide you in comprehension and retention of the subject
writer, and I found myself bringing that same enjoyment of writing matter.
and illustrating to the first edition of this book you are now hold- I hope you enjoy your study of this book, but I know there are
ing. Why? Not only for its intrinsic creative satisfaction, but always ways to make it even better. Indeed, what quality you may
because I’m guessing that you’re like I was—you can appreciate a find in this edition owes a great deal to feedback I’ve received from
book that does more than simply give you the information you students all over the world. If you find any typos or other errors, if
need. You appreciate, I trust, a writer who makes it enjoyable for you have any suggestions for improvement, if I can clarify a con-
you through his scientific, storytelling prose and his concept of the cept for you, or even if you just want to comment on something
way things should be illustrated to spark interest and facilitate you really like about the book, I hope you’ll feel free to write to
understanding. me. I correspond quite a lot with students and would enjoy hearing
I know from my own students, however, that you need more from you.
than captivating illustrations and enjoyable reading. Let’s face it—
A&P is a complex subject and it may seem a formidable task to Ken Saladin
acquire even a basic knowledge of the human body. It was difficult Georgia College
even for me to learn (and the learning never ends). So in addition Milledgeville, GA 31061 (USA)
to simply writing this book, I’ve given a lot of thought to its ksaladin2@windstream.net
xxi
PART ON E : OR GAN IZ AT IO N O F TH E BO DY
1
CHAPTER
MAJOR THEMES
OF ANATOMY
AND PHYSIOLOGY
hormones), and pathophysiology (mechanisms of disease). Partly usually considered to be the Greek physician Hippocrates
because of limitations on experimentation with humans, much (c. 460–c. 375 bce). He and his followers established a code
of what we know about bodily function has been gained through of ethics for physicians, the Hippocratic Oath, which is still
comparative physiology, the study of how different species have recited in modern form by graduating physicians at some medi-
solved problems of life such as water balance, respiration, and re- cal schools. Hippocrates urged physicians to stop attributing
production. Comparative physiology is also the basis for the de- disease to the activities of gods and demons and to seek their
velopment of new drugs and medical procedures. For example, natural causes, which could afford the only rational basis for
a cardiac surgeon may learn animal surgery before practicing on therapy.
humans, and a vaccine cannot be used on human subjects until Aristotle (384–322 bce) was one of the first philosophers to
it has been demonstrated through animal research that it confers write about anatomy and physiology. He believed that diseases and
significant benefits without unacceptable risks. other natural events could have either supernatural causes, which
he called theologi, or natural ones, which he called physici or phys-
BE FOR E YOU GO ON iologi. We derive such terms as physician and physiology from the
latter. Until the nineteenth century, physicians were called “doctors
Answer the following questions to test your understanding of
of physic.” In his anatomy book, On the Parts of Animals, Aristotle
the preceding section:
tried to identify unifying themes in nature. Among other points, he
1. What is the difference between anatomy and physiology? argued that complex structures are built from a smaller variety of
How do these two sciences support each other? simple components—a perspective that we will find useful later in
2. Name the method that would be used for each of the fol- this chapter.
lowing: listening to a patient for a heart murmur; studying
the microscopic structure of the liver; microscopically
▶▶▶APPLY WHAT YOU KNOW
examining liver tissue for signs of hepatitis; learning the
When you have completed this chapter, discuss the
blood vessels of a cadaver; and performing a breast
relevance of Aristotle’s philosophy to our current thinking
self-examination.
about human structure.
intended more to decorate a page than to depict the body real- Among Muslims, probably the most highly regarded medical
istically (fig. 1.1a). Some were astrological charts that showed scholar was Ibn Sina (980–1037), known in the West as Avicenna
which sign of the zodiac was thought to influence each organ or “the Galen of Islam.” He studied Galen and Aristotle, combined
of the body. From such pseudoscience came the word influenza, their findings with original discoveries, and questioned authority
Italian for “influence.” when the evidence demanded it. Medicine in the Mideast soon
Free inquiry was less inhibited in Jewish and Muslim cul- became superior to European medicine. Avicenna’s textbook, The
ture during this time. Jewish physicians were the most esteemed Canon of Medicine, was the leading authority in European medical
practitioners of their art—and none more famous than Moses ben schools for over 500 years.
Maimon (1135–1204), known in Christendom as Maimonides. Chinese medicine had little influence on Western thought and
Born in Spain, he fled to Egypt at age 24 to escape antisemitic practice until relatively recently; the medical arts evolved in China
persecution. There he served the rest of his life as physician to the quite independently of European medicine. Later chapters of this
court of the sultan, Saladin. A highly admired rabbi, Maimonides book describe some of the insights of ancient China and India.
wrote voluminously on Jewish law and theology, but also wrote Modern Western medicine began around the sixteenth
10 influential medical books and numerous treatises on specific century in the innovative minds of such people as the anato-
diseases. mist Andreas Vesalius and the physiologist William Harvey.
(a) (b)
FIGURE 1.1 The Evolution of Medical Art. Two illustrations of the skeletal system made about 500 years apart. (a) From an eleventh-
century work attributed to Persian physician Avicenna. (b) From De Humani Corporis Fabrica by Andreas Vesalius, 1543.
a: Source: Wellcome Library, London/CC BY 4.0; b: Suzan Oschmann/Shutterstock
CHAPTER 1 Major Themes of Anatomy and Physiology 5
Andreas Vesalius (1514–64) taught anatomy in Italy. In his time, image, and an ocular lens (eyepiece) near the observer’s eye,
the Catholic Church relaxed its prohibition against cadaver dissec- which magnifies the first image still further. Although crude
tion, in part to allow autopsies in cases of suspicious death. Fur- compound microscopes had existed since 1595, Hooke improved
thermore, the Italian Renaissance created an environment more the optics and invented several of the helpful features found in
friendly to innovative scholarship. Dissection gradually found its microscopes today—a stage to hold the specimen, an illumina-
way into the training of medical students throughout Europe. It tor, and coarse and fine focus controls. His microscopes mag-
was an unpleasant business, however, and most professors consid- nified only about 30 times, but with them, he was the first to
ered it beneath their dignity. In those days before refrigeration or see and name cells. In 1663, he observed thin shavings of cork
embalming, the odor from the decaying cadaver was unbearable. and observed that they “consisted of a great many little boxes,”
Dissections were a race against decay. Bleary medical students which he called cellulae (little cells) after the cubicles of a
had to fight the urge to vomit, lest they incur the wrath of an over- monastery (fig. 1.2). He later observed living cells “filled with
bearing professor. Professors typically sat in an elevated chair, the juices.” Hooke became particularly interested in microscopic ex-
cathedra, reading dryly in Latin from Galen or Aristotle while a amination of such material as insects, plant tissues, and animal
lower-ranking barber–surgeon removed putrefying organs from parts. He published the first comprehensive book of microscopy,
the cadaver and held them up for the students to see. Barbering Micrographia, in 1665.
and surgery were considered to be “kindred arts of the knife”; Antony van Leeuwenhoek (an-TOE-nee vahn LAY-wen-
today’s barber poles date from this era, their red and white stripes hook) (1632–1723), a Dutch textile merchant, invented a simple
symbolizing blood and bandages. (single-lens) microscope, originally for the purpose of exam-
Vesalius broke with tradition by coming down from the ining the weave of fabrics. His microscope was a beadlike lens
cathedra and doing the dissections himself. He was quick
mounted in a metal plate equipped with a movable specimen clip.
to point out that much of the anatomy in Galen’s books was
wrong, and he was the first to publish accurate illustrations for
teaching anatomy (fig. 1.1b). When others began to plagiarize
them, Vesalius published the first atlas of anatomy, De Humani
Corporis Fabrica (On the Structure of the Human Body), in
1543. This book began a rich tradition of medical illustration
that has been handed down to us through such milestones as
Gray’s Anatomy (1856) and the vividly illustrated atlases and
textbooks of today.
Anatomy preceded physiology and was a necessary
foundation for it. What Vesalius was to anatomy, the Englishman
William Harvey (1578–1657) was to physiology. Harvey is
remembered especially for his studies of blood circulation and
a little book he published in 1628, known by its abbreviated
title De Motu Cordis (On the Motion of the Heart). He and
Michael Servetus (1511–53) were the first Western scientists
to realize that blood must circulate continuously around the
body, from the heart to the other organs and back to the heart
again. This flew in the face of Galen’s belief that the liver con-
verted food to blood, the heart pumped blood through the veins
to all other organs, and those organs consumed it. Harvey’s
colleagues, wedded to the ideas of Galen, ridiculed Harvey for
his theory, though we now know he was correct (see chapter 20
prologue). Despite persecution and setbacks, Harvey lived to
a ripe old age, served as physician to the kings of England,
and later did important work in embryology. Most importantly,
Harvey’s contributions represent the birth of experimental
physiology—the method that generated most of the information
in this book.
(a) (b)
Modern medicine also owes an enormous debt to two
inventors from this era, Robert Hooke and Antony van
FIGURE 1.2 Hooke’s Compound Microscope. (a) The
Leeuwenhoek, who extended the vision of biologists to the cellu- compound microscope had a lens at each end of a tubular body.
lar level. Robert Hooke (1635–1703), an Englishman, designed (b) Hooke’s drawing of cork cells, showing the thick cell walls
scientific instruments of various kinds, including the compound characteristic of plants.
microscope. This is a tube with a lens at each end—an objec- a: Source: National Museum of Health and Medicine, Silver Spring, MD; b: Bettmann/
tive lens near the specimen, which produces an initial magnified Getty Images
6 PART ONE Organization of the Body
Even though his microscopes were simpler than Hooke’s, they and the structure of DNA. In the twentieth century, basic biol-
achieved much greater useful magnification (up to 200×) owing ogy and biochemistry yielded a much deeper understanding of
to Leeuwenhoek’s superior lens-making technique. Out of cu- how the body works. Advances in medical imaging enhanced
riosity, he examined a drop of lake water and was astonished to our diagnostic ability and life-support strategies. We witnessed
find a variety of microorganisms—“little animalcules,” he called monumental developments in chemotherapy, immunization, an-
them, “very prettily a-swimming.” He went on to observe practi- esthesia, surgery, organ transplants, and human genetics. By the
cally everything he could get his hands on, including blood cells, close of the twentieth century, we had discovered the chemical
blood capillaries, sperm, muscular tissue, and bacteria from tooth “base sequence” of every human gene and begun attempting gene
scrapings. Leeuwenhoek began submitting his observations to the therapy to treat children born with diseases recently considered
Royal Society of London in 1673. He was praised at first, and his incurable. As future historians look back on the turn of this cen-
observations were eagerly read by scientists, but enthusiasm for tury, they may exult about the Genetic Revolution in which you
the microscope didn’t last. By the end of the seventeenth century, are now living.
it was treated as a mere toy for the upper classes, as amusing and Several discoveries of the nineteenth and twentieth centuries,
meaningless as a kaleidoscope. Leeuwenhoek and Hooke had even and the men and women behind them, are covered in short his-
become the brunt of satire. But probably no one in history had torical sketches in later chapters. Yet, the stories told in this chap-
looked at nature in such a revolutionary way. By taking biology to ter are different in a significant way. The people discussed here
the cellular level, the two men had laid an entirely new foundation were pioneers in establishing the scientific way of thinking. They
for the modern medicine to follow centuries later. helped to replace superstition with an appreciation of natural law.
The Hooke and Leeuwenhoek microscopes produced poor They bridged the chasm between mystery and medication. With-
images with blurry edges (spherical aberration) and rainbow- out this intellectual revolution, those who followed could not have
like distortions (chromatic aberration). These problems had to conceived of the right questions to ask, much less a method for
be solved before the microscope could be widely used as a bio- answering them.
logical tool. In the nineteenth century, German inventors greatly
improved the compound microscope, adding the condenser and
developing superior optics. With improved microscopes, biolo- BEFORE YOU GO ON
gists began eagerly examining a wider variety of specimens. By Answer the following questions to test your understanding
1839, botanist Matthias Schleiden (1804–81) and zoologist of the preceding section:
Theodor Schwann (1810–82) concluded that all organisms were 3. In what way did the followers of Galen disregard his advice?
composed of cells. Although it took another century for this idea How does Galen’s advice apply to you and this book?
to be generally accepted, it became the first tenet of the cell theory,
4. Describe two ways in which Vesalius improved medical
added to by later biologists and summarized in section 3.1a. The
education and set standards that remain relevant today.
cell theory was perhaps the most important breakthrough in bio-
medical history; all functions of the body are now interpreted as 5. How is our concept of human form and function today
the effects of cellular activity. affected by inventors from the seventeenth to the nine-
Although the philosophical foundation for modern medicine teenth centuries?
was largely established by the time of Leeuwenhoek, Hooke, and
Harvey, clinical practice was still in a dismal state. Few doctors
attended medical school or received any formal education in basic
science or human anatomy. Physicians tended to be ignorant, inef- 1.3 Scientific Method
fective, and pompous. Their practice was heavily based on expel-
Expected Learning Outcomes
ling imaginary toxins from the body by bleeding their patients or
inducing vomiting, sweating, or diarrhea. They performed opera- When you have completed this section, you should be able to
tions with filthy hands and instruments, spreading lethal infections a. describe the inductive and hypothetico–deductive
from one patient to another and refusing, in their vanity, to be- methods of obtaining scientific knowledge;
lieve that they themselves were the carriers of disease. Countless b. describe some aspects of experimental design that help
women died of infections acquired during childbirth from their to ensure objective and reliable results; and
obstetricians. Fractured limbs often became gangrenous and had
c. explain what is meant by hypothesis, fact, law, and theory
to be amputated, and there was no anesthesia to lessen the pain.
in science.
Disease was still widely attributed to demons and witches, and
many people felt they would be interfering with God’s will if they
tried to treat it.
Prior to the seventeenth century, science was done in a haphazard
way by a small number of isolated individuals. The philosophers
1.2c Living in a Revolution Francis Bacon (1561–1626) in England and René Descartes
This short history brings us only to the threshold of modern (1596–1650) in France envisioned science as a far greater, sys-
biomedical science; it stops short of such momentous discover- tematic enterprise with enormous possibilities for human health
ies as the germ theory of disease, the mechanisms of heredity, and welfare. They detested those who endlessly debated ancient
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[1018] P. C. S. M., I., 126.
[1019] Ibid., 130.
[1020] Ibid., 128.
[1021] Ibid., 145.
[1022] Ibid., 216.
[1023] Ibid., 221.
[1024] Ibid., 239.
[1025] Ibid., 266.
[1026] Ibid., 288.
[1027] Ibid., 276, 277, 279.
[1028] P. C. S. M., I., 309.
[1029] Ibid., 288.
[1030] Min. Phila. Mo. Mtg. 7-30-1779, 151.
[1031] Ibid. (An extract of the report to the monthly meeting is
given on page 71ff., chapter on Philadelphia, showing the state of
schools in 1784.)
[1032] Ibid., 1-30-1784, 123ff.
[1033] Ibid., 1-25-1793, 184.
[1034] Min. Phila. Mo. Mtg., 2-23-1798, 149.
[1035] Quoted in Jenkins’ Hist. Collections of Gwynedd, 396-7.
[1036] The works from which the notices were taken: Watson,
Annals of Philadelphia; Simpson, Lives of Eminent
Philadelphians; Jordan, Colonial Families of Philadelphia;
Oberholtzer, Philadelphia City and Its People; W. Thompson,
History of Philadelphia.
[1037] Vaux, Memoirs, p. 7; also Keyser, Old Germantown, I,
79.
[1038] P. C. S. M., I, 33.
[1039] Ibid., 117.
[1040] Oberholtzer, I, 233.
[1041] P. C. S. M., I, 117.
[1042] Vaux, Memoirs, p. 8
[1043] P. C. S. M., I, 114.
[1044] Ibid., 115.
[1045] Ibid., 161.
[1046] Ibid., 244.
[1047] Ibid., 311.
[1048] Min. Phila. Mo. Mtg., 5-31-1782, 28.
[1049] For list of his works, see Hildeburn or Smith.
[1050] P. C. S. M., I, 21.
[1051] Pa. Gaz., No. 673, 1741.
(Advertising for pupils in newspapers was not the usual rule
among Quaker masters in early Pennsylvania, though some
cases occurred. 345 advertisements from 1730 to 1790 have
been noted in various newspapers of the period. Of a list of
seventy Quakers who are known to have taught school, only 15
were found in the list of advertisers. The papers examined were
the Weekly Mercury, Pennsylvania Gazette, Freeman’s Journal,
Evening Post, Pennsylvania Journal and Weekly Advertiser, Pa.
Packet, and the Pa. Chronicle; also the Courrier Francais (which
is not mentioned in the bibliography).)
[1052] Min. Phila. Mo. Mtg., 1-30-1784, 123.
[1053] Ibid., 1-25-1793, 184.
[1054] Ibid., 2-23-1798, 149.
[1055] Ibid., 11-28-1800, 300.
[1056] Oberholtzer, I, 181.
[1057] Min. Phila. Mo. Mtg., 1-29-1700, 254.
[1058] Min. Phila. Mo. Mtg., 2-24-1702, 329.
[1059] Ibid., 6-27-1703, 376.
[1060] Am. Wk. Mercury, Nov. 29, 1733.
[1061] Watson I, 287.
[1062] Min. Phila. Mo. Mtg., 3-29-1691, 146.
[1063] Collections of the Protestant Episcopal Historical Soc.,
1851, Vol. I, XIX to XX.
[1064] Min. Phila. Mo. Mtg., 1-30-1784, 123ff.
[1065] Moses Patterson was the first teacher in the Negro
School. Phila. Mo. Mtg. Min., 6-29-1799, 398.
[1066] P. C. S. M., I, 274.
[1067] P. C. S. M., I, 208.
[1068] Ibid., 272.
[1069] Ibid., 288.
[1070] Min. Phila. Mo. Mtg., 6-26-1748, 64.
[1071] P. C. S. M., I, 101.
[1072] Ibid., 84.
[1073] Ibid., 122.
[1074] Ibid., 131.
[1075] Ibid., 133.
[1076] Pa. Gaz., No. 1403, 1755.
[1077] P. C. S. M., I, 133.
[1078] P. C. S. M., I, 106.
[1079] Ibid., 122.
[1080] Ibid., 131.
[1081] Ibid., 141.
[1082] Ibid., 188.
[1083] Simpson, 912-13.
[1084] P. C. S. M., I, 175.
[1085] Ibid., 234.
[1086] Ibid., 334.
[1087] Min. Phila. Mo. Mtg., 1-30-1784, 123.
[1088] Robert Proud Ms. Col., No. 20, 27.
[1089] Watson, I, 282.
[1090] Min. Phila. Mo. Mtg., 7-30-1779, 151.
[1091] The Public School Gazetteer, 1777, in Norris Ms.
Collections, H. S. P.
[1092] P. C. S. M., I, 90.
[1093] Ibid., 117.
[1094] Ibid., 198.
[1095] Ibid., 199.
[1096] Ibid., 266.
[1097] Min. Phila. Mo. Mtg., 7-30-1779, 151.
[1098] Ibid., 1-30-1784, 123f.
[1099] Watson, I, 290f.
[1100] Ibid., 292.
[1101] Ibid., 290.
[1102] Ibid., 291.
[1103] Min. Phila. Mo. Mtg., 7-30-1779, 151.
[1104] P. C. S. M., I, 24.
[1105] Ibid., 165.
[1106] Pa. Gaz., No. 1951, 1766.
[1107] Ibid.
[1108] Pa. Gaz., No. 1865, 1764.
[1109] P. C. S. M., I, 164.
[1110] Ibid., 173.
[1111] The last eight mentioned are named as teachers in
Gwynedd neighborhood school, by Joseph Foulke. (Jenkins, 396-
7.)
[1112] Min. Abington Mo. Mtg., 4-25-1711, 73.
[1113] Min. Phila. Mo. Mtg., 2-27-1722, 83.
[1114] Min. Abington Mo. Mtg., 10-29-1753, 111.
[1115] Pa. Gaz., No. 2371, 1774. Ibid., No. 2147, 1770. Ibid.,
No. 2118, 1769. Ibid., No. 1821, 1763.
[1116] Wickersham, 26.
[1117] Ibid., 27.
[1118] Prowell, I, 539.
[1119] Ibid., 541
[1120] Name found in the account book for the Jonathan
Walton Fund used for that meeting, p. 1. (Deposited at Friends
Meeting House in Quakertown, Pa.)
[1121] Min. Horsham Mo. Mtg., 4-28-1784.
[1122] Ibid.
[1123] Min. Horsham Sch. Com., 1-11-1793.
[1124] Min. Horsham Mo. Mtg., 4-28-1784.
[1125] Min. Exeter Mo. Mtg., 4-28-1784, 510f.
[1126] Ibid.
[1127] Ibid., 10-31-1787, 60f.
[1128] Pa. Mag. Hist., XXV, 3.
[1129] Proud, Hist. of Pa., I, 233 and 109f. See Ms. description
of the province of Pennsylvania written by William Penn relating
to the first settlement written 1682. A copy in Logan Ms.
Collections, Vol. 1.
[1130] 2 Pa. Archives, XVI, 234.
[1131] Hazard, Annals of Pa., 331. N. Y. Col. Doc. II, 213-14.
[1132] Col. Rec., XII, 99.
[1133] Laws of Pa., III, 269-272; 3 Pa. Archives, XVIII, 303-430.
[1134] Ms. Ancient Rec. of Phila., July 28, 1702.
[1135] Turner, The Negro in Pa., 79.
[1136] London Yr. Mtg., Epistles, 1772, 394.
[1137] 3 Pa. Archives, XVIII, 303-430.
[1138] Turner, The Negro in Pa.
[1139] Stat. at Large of Pa., II, 107, 285.
[1140] Ms. Bd. of Trade Papers, Proprieties, IX, Q, 39, 42; Stat.
at Large of Pa., II, 543-4.
[1141] Watson, Annals of Phila., II, 264.
[1142] Ms. Bd. of Trade Papers, Proprieties, IX, Q, 39, 42; Stat.
at Large of Pa. II, 543-4.
[1143] Votes and Proceedings, 1726-1742, 31.
[1144] Smith, Hist. of Del. Co., 261; Kaln, Travels, I, 391.
[1145] Pa. Gaz. and Wk. Advt., 1779, No. 2580.
[1146] Col. Rec., XII, 99.
[1147] The quality of the clothing on their backs does not
necessarily mean they enjoyed a good location. It was in many
cases stolen goods.
[1148] Pa. Gaz., No. 2568, 1779.
[1149] Watson, Annals, I, 406.
[1150] Heatwole, Hist. of Ed. in Va., 299.
[1151] Pa. Mag. of Hist., XXIX, 363.
[1152] Smith, H. W., Life of W. Smith, I, 238.
[1153] Pa. Gaz., 1740, 624; Am. Wk. Mer., 1740, No. 1097.
[1154] Am. Wk. Mer., 1722-3, IV, 16.
[1155] Ibid.
[1156] Pa. Archives, XVIII, 303-430. Ibid., XXI, 165-324. Ibid.,
XVII, 489-685.
[1157] Christian Doc. Prac. and Dis. Relig. Soc. of Friends,
1727, 122, (published 1861). Ibid., extract of 1758.
[1158] Friends’ Lib., I, 79.
[1159] Woolman’s Works, 15.
[1160] Turner, Negro in Pa., 67.
[1161] Woolman’s Words, 156-7.
[1162] Ibid., 78.
[1163] Ibid., 44.
[1164] Woolman’s Works, 96-7.
[1165] Ibid., 244.
[1166] Most significant works are given in the bibliography.
[1167] Min. Phila. Mo. Mtg., 1-30-1784, 128.
[1168] Ibid., 6-29-1770, 398.
[1169] Benezet, A Short Account of the People Called Quakers,
81-2.
[1170] Vaux, Memoirs of Lay and Sandiford.
[1171] Pa. Mag. of Hist., XIII, 265; Old Germantown,
Lippincott’s Mag., Feb., 1884, 118ff., containing an account of the
protest; Phila. Quarterly Meeting would not take action, it being
considered too weighty a question (Min. Phila. Q. Mtg., 4-4-1688,
136.)
[1172] Pa. Mag. of Hist., 266, 268.
[1173] Christian Doc. Prac. and Discipline, 1727, pub. 1861,
122.
[1174] Min. Phila. Mo. Mtg., 4-30-1756, 215.
[1175] Epistles London Yr. Mtg., 1772, 394.
[1176] Christian Doc. Prac. and Discipline, 1758, pub. 1861,
122.
[1177] Extracts Buckingham Mo. Mtg., 12-6-1762, 107.
[1178] Min. Phila. Mo. Mtg., 4-30-1756, 215; Concord Mo. Mtg.,
6-9-1779, 86; Horsham Sch. Com, 8-17-1792; Chester Mo. Mtg.,
10-25-1779, 31; Uwchlan Mo. Mtg., 9-9-1779, 65f.; Sadsbury, 7-
17-1782, 340.
[1179] Min. Phila. Mo. Mtg., 4-30-1756, 215 and 1-25-1765, 7.
[1180] Ibid., 7.
[1181] Ibid., 1-26-1770, 371; (Proud in his Ms. History of
Philadelphia gives Benezet the whole credit of establishing the
Negro school. There were two branches, one for boys and one for
girls, taught by different tutors. He says the successful outcome of
this school of Benezet’s was the incentive which caused the
Abolition Society to establish others.) See Proud’s Ms. History, p.
64. H. S. P.
[1182] Min. Phila. Mo. Mtg., 2-23-1770, 376.
[1183] Ibid., 3-30-1770, 379.
[1184] Min. Phila. Mo. Mtg., 3-30-1770, 379.
[1185] Ibid.
[1186] Ibid., 1-25-1771, 430.
[1187] Ibid., 6-29-1770, 398.
[1188] Ibid., 1-25-1771, 430.
[1189] Ibid., 2-28-1777, 438.
[1190] Min. Phila. Mo. Mtg., 5-31-1782, 28; 1-25-1793, 184; 3-
30-1770, 379.
[1191] Ibid.
[1192] Ibid.
[1193] Ibid.
[1194] Ibid.
[1195] Dewey, p. 39.
[1196] Min. Phila. Mo. Mtg., 3-30-1770, 379.
[1197] Ibid., 4-26-1771, 444, and 21-25-1772, 145.
[1198] Ibid., 7-28-1786, 271.
[1199] Ibid., 1-30-1784, 128.
[1200] Ibid., 1-25-1793, 184.
[1201] Ibid.
[1202] Min. Phila. Mo. Mtg., 1-25-1793, 184.
[1203] For an insight to the real value of the money see note p.
212 of this work; also Dewey, p. 39.
[1204] Ibid.
[1205] Ibid., 2-23-1798, 149.
[1206] Ibid.
[1207] Ibid.
[1208] Ms. Minutes of the Committee on Negro Education, I,
19; other expenditures mentioned are for copy books, ciphering
books, child’s spelling books, lessons for youth, writing paper, red
blotting paper, slates, quills, ink, tutors’ assistants, Cheap
Repository, 4 volumes, and one set Murray’s Introduction, I, 138.
[1209] Min. Phila. Mo. Mtg., 11-28-1800, 300; Ibid., 2-23-1798,
149.
[1210] Ibid.
[1211] Min. Exeter Mo. Mtg., 7-26-1764, 519.
[1212] Min. Uwchlan Mo. Mtg., 9-9-1779, 65; Min. Sadsbury
Mo. Mtg., 7-17-1782, 340.
[1213] Min. Uwchlan Mo. Mtg., 9-9-1779, 65f.
[1214] Ibid.
[1215] Min. Deercreek Mo. Mtg., 7-24-1779, 304.
[1216] Ibid., 11-23-1776, 274.
[1217] Ibid.
[1218] Min. Sadsbury Mo. Mtg., 7-17-1782, 340.
[1219] Min. Chester Mo. Mtg., 10-25-1779, 31.
[1220] Extracts, Buckingham Mo. Mtg., 12-6-1779, 202; (this
was a part of the discipline).
[1221] Ibid., 12-6-1762, 107.
[1222] Min. Uwchlan Mo. Mtg., 9-9-1779, 65f.
[1223] Cf. Report on Philadelphia, pp. 68f.
[1224] Min. Exeter Mo. Mtg., 7-26-1764, 519.
[1225] Ibid., 10-26-1758, 301.
[1226] Min. Radnor Mo. Mtg., 10-12-1756, 287.
[1227] Ibid., 1-11-1757, 300; 4-10-1759, 28; 6-8-1764, 54; 7-8-
1766, 139.
[1228] Ibid., 7-8-1766, 139.
[1229] Min. Radnor Mo. Mtg., 7-12-1768, 209.
[1230] Ibid., 7-10-1770, 286.
[1231] Ibid.
[1232] Ibid., 10-8-1776, 102; 8-13-1779, 171; 11-12-1779, 179.
[1233] Ibid., 12-10-1778, 145.
[1234] Ibid., 11-13-1778, 140.
[1235] Ibid., 7-1-1780, 198.
[1236] Ibid., 7-13-1790, 7.
[1237] Ibid.
[1238] See p. 228ff.; also Davis, Hist. Bucks Co., II, 294.
[1239] Col. Rec. XII, 99.
[1240] Davis, Hist., II, 297.
[1241] Davis, Hist., II, 295.
[1242] Ibid.
[1243] Min. Middletown Mo. Mtg., 8-1-1782, 535.
[1244] Ibid., 8-7-1783, 557.
[1245] Extracts, Min. Buckingham Mo. Mtg., 12-6-1762, p. 107.
[1246] Ibid., 11-2-1778, 181.
[1247] Min. Bucks Q. Mtg., 8-28-1777, 29.
[1248] Min. Buckingham Mo. Mtg., 12-6-1779, 202.
[1249] Min. Bucks Q. Mtg., 2 vols., 1684-1804. Newtown First
Nat’l Bank.
[1250] Ibid., 6-27-1730.
[1251] Ibid.
[1252] Ibid., 8-28-1766.
[1253] Ibid., 8-27-1772.
[1254] Ibid., 8-28-1777, 29.
[1255] Min. Bucks Q. Mtg., 8-28-1777, 29.
[1256] Ibid., 11-27-1777, 33.
[1257] Ibid., 8-27-1795.
[1258] Ibid., 2-28-1799, 289.
Ibid., 2-7-1758.
[1259] Min. Falls Mo. Mtg., 2-2-1757.
[1260] Ibid., 8-7-1771, 86; 8-5-1772, 105; 9-6-1780, 275; 8-6-
1783, 350.
[1261] Ibid., 8-1-1781, 301; 3-2-1763; 2-4-1767; 7-2-1769.
[1262] Min. Buckingham Mo. Mtg., 11-2-1778, 181; 8-1762,
107.
[1263] Davis, Hist. Bucks Co., II, 297.
[1264] Ibid., 296.
[1265] Ibid., 297.
[1266] Min. London Mo. Mtg. 1792, I (deposited at L. G. Mtg.).
[1267] Min. Kennett Mo. Mtg., 8-16-1770—439.
[1268] Ibid., 10-16-1777, 619.
[1269] Ibid., 1-14-1779, 658.
[1270] Min. Kennett Mo. Mtg., 8-14-1788, 887.
[1271] Futhey and Cope, 424.
[1272] Min. New Garden Mo. Mtg., 12-5-1778, 419 (committee
had been appointed in 1774).
[1273] Ibid., 5-5-1781, 108.
[1274] Ibid., 9-1-1781, 119.
[1275] Ibid., 8-6-1785, 256.
[1276] Ibid., 9-5-1789, 419.
[1277] Futhey and Cope, Hist. of Chester Co., 424.
[1278] Min. Uwchlan Mo. Mtg., 3-1-1765, 66.
[1279] Min. Uwchlan Mo. Mtg., 9-9-1779, 65f.
[1280] Ibid.
[1281] Ibid.
[1282] Min. Middletown Mo. Mtg., 1-7-1699, 113.
[1283] Min. Sadsbury Mo. Mtg., 7-17-1782, 340.
[1284] Ibid.
[1285] Ibid.
[1286] Col. Rec., XII, 99; Laws of Pa., III, 268-272.
[1287] Futhey and Cope, 424.
[1288] Min. Chester Mo. Mtg., 10-25-1779, 31.
[1289] Ibid.
[1290] Ibid., 7-30-1781, 73f.
[1291] Ibid., 9-23-1785, 177.
[1292] Min. Concord Mo. Mtg., 6-9-1779, 86.
[1293] Min. Goshen Mo. Mtg., 10-18-1756.
[1294] Ibid., 7-18-1757.
[1295] Ibid., 7-17-1758.
[1296] Ibid., 2-5-1762.
[1297] Ibid., 8-6-1762.
[1298] Ibid., 2-10-1764.
[1299] Ibid., 4-5-1776.
[1300] Ibid., 3-7-1777.
[1301] Min. Goshen Mo. Mtg., 7-10-1778.
[1302] Ibid., 12-11-1778.
[1303] Ibid., 8-11-1780.
[1304] Futhey and Cope, 424.
[1305] This statement is based on the results of G. Cope’s
study of local history.
[1306] Bunting, Recs., Mtg. Phila. Yr. Mtg., 24.
[1307] Rec. Horsham School Com., 11-15-1793.
[1308] Martindale, Hist. of Byberry and Moreland, 49.
[1309] Ibid., 50. (The sources used by Martindale are not
found.)
[1310] Min. Byberry Prep. Mtg., 9-15-1779.
[1311] Min. Gwynedd Mo. Mtg., 4-25-1756, 215.
[1312] Min. Gwynedd Mo. Mtg., 7-27-1756, 164.
[1313] Ibid., 7-28-1767, 13.
[1314] Ibid., 7-26-1768, 40.
[1315] Min. Gwynedd Mo. Mtg., 8-27-1775, 202.
[1316] Ibid., 5-25-1779, 306.
[1317] Ibid., 8-26-1783, 172.
[1318] Ibid., 7-27-1790, 112.
[1319] Kaln, P., Travels into North America, I, 390, 394.
[1320] Min. Warrington and Fairfax Q. Mtg., 9-16-1776, 11.
[1321] Ibid., 9-20-1779, 73. (Warrington Meeting, in the County
of York.)
[1322] Applegarth, Quakers in Pa., Johns Hopkins Univ.
Studies, VIII-IX, 56.
[1323] Mention should also be made of the Friendly Ass’n for
Preserving Peace with the Indians. For reference see Vol. 3,
Penn’s MS., relating to Indian Affairs, pp. 17-18, an address to
Governor Dewey, 1757; also p. 89, an address to Proprietaries
Thomas Penn and Richard Penn on same subject.
[1324] Col. Rec. II, 16.
[1325] Ibid., III, 356.
[1326] Bowden, II, 70.
[1327] London Yr. Mtg. Epistles, 1795, 487.
[1328] Conduct of the Society of Friends towards Indians, 98-
99.
[1329] Ibid.
[1330] A brief account of the Committee’s proceedings (pub. in
Phila.), 7.
[1331] Ibid.
[1332] Ibid.
[1333] Ibid.
[1334] Conduct of the Society of Friends towards Indians, 10.
[1335] Ibid., 8, 9, 10.
[1336] Ibid., 11.
[1337] See page 263.
[1338] No summary is given of conditions in each of the
meetings; if desired, see in index, “negro education.”
[1339] The digest of the standards to be attained may be seen
on pages 172f.
[1340] Bowden, II, 247ff. (tables showing the particular monthly,
and quarterly meetings, etc.).
[1341] See in index: Merion and Valley, for example.
[1342] Bowden, II, 157.
[1343] Ibid., 156; quoted from Oldmixon, I, 304.
[1344] 6,200 new settlers came in 1729 (Bowden, II, 156).
[1345] Ibid., 157.
[1346] Winterbotham, II, 438-439; also, census report, 1790.
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