Lipid Digestion, Absorption &

Transportation

Submitted by-
Priyanka Bhalla
Sec-”O” 5028
Source of Energy in our body
Carbohydrates

Lipids

Proteins
 Lipid Digestion & Absorption
Dietary lipids Stomach
in mouth (chyme)

Small lipid droplets Duodenum

-emulsification by (large lipid
bile salts aggregates)

Forms free fatty Retain association

acids by hydrolysis to form micelles
by lipases in lumen

Transported to ER for
Enter enterocytes
conversion of micelles
into triglycerides through diffusion

Move to Golgi complex

to combine with
cholesterol &
 No digestion
takes place here cause
SALIVA contains NO
LIPASE
Dietary lipids Stomach
in mouth (chyme)

Small lipid droplets Duodenum

-emulsification by (large lipid
bile salts aggregates)

Forms free fatty Retain association

acids by hydrolysis to form micelles
by lipases in lumen

Transported to ER for
Enter enterocytes
conversion of micelles
into triglycerides through diffusion

Move to Golgi complex

to combine with
cholesterol &
Dietary lipids Stomach
in mouth (chyme)

Small lipid droplets Duodenum

-emulsification by (large lipid
bile salts aggregates)

Forms free fatty In stomach the food is partly digested

Retain association
acids by hydrolysis to to
form
formamicelles
semi fluid mass called
by lipases in lumen
CHYME. But still full digestion
doesn’t take place cause stomach
lacks fat-emulsifying agent.
Transported to ER for
Enter enterocytes
conversion of micelles
into triglycerides through diffusion

Move to Golgi complex

to combine with
cholesterol &
apoprotiens
Dietary lipids Stomach
in mouth (chyme)

Small lipid droplets Duodenum

-emulsification by (large lipid
bile salts Gastric juice in duodenum contains aggregates)
gastric lipases which converts some
fats into monoglycerides and fatty
Forms free fatty Retain association
acids
acids by hydrolysis to form micelles
by lipases in lumen

Transported to ER for
Enter enterocytes
conversion of micelles
into triglycerides through diffusion

Move to Golgi complex

to combine with
cholesterol &
apoprotiens
 Duodenum
Dietary lipids Stomach (large lipid
in mouth (chyme) dissociate
Large lipid aggregates aggregates)

into small lipid droplets due to

EMULSIFICATION
Forms free fatty by BILE SALTS
Small lipid droplets
acids by hydrolysis -emulsification by
which are obtained by Cholesterol
by lipases bile salts
Metabolism.
Retain association Transported to ER for
Enter enterocytes
to form micelles conversion of micelles
through diffusion into triglycerides
in lumen

Move to Golgi complex

to combine with
cholesterol &
apoprotiens
 Lipid Digestion & Absorption
Dietary lipids Stomach
in mouth (chyme)

Small lipid droplets Duodenum

-emulsification by (large lipid
bile salts aggregates)

Forms free fatty Retain association

acids by hydrolysis to form micelles
by lipases in lumen

Transported to ER for
Enter enterocytes
conversion of micelles
into triglycerides through diffusion

Move to Golgi complex

to combine with
cholesterol &
Dietary lipids Stomach
in mouth (chyme)

Small lipid droplets Duodenum

-emulsification by (large lipid
bile salts aggregates)

Forms free fatty Retain association

acids by hydrolysis to form micelles
by lipases in lumen

Transported to ER for
Enter enterocytes
conversion of micelles
into triglycerides through diffusion

Fatty acids retain association with bile salts

and complex with other lipid molecules to
Move to Golgi complex
to combine with
form micelles of 4-8 nm diameter
cholesterol &
apoprotiens
 Lipids are broken down by
Dietary lipids pancreatic lipase and bile, and Stomach
in mouth then diffuse into the (chyme)
ENTEROCYTES. Smaller lipids are
transported into intestinal
Small lipid droplets Duodenum
capillaries, while larger lipids are
-emulsification by (large lipid
processedbilebysalts
the Golgi and aggregates)
smooth endoplasmic reticulum
into lipoprotein chylomicra and
Forms free fatty exocytozed into lacteals. Retain association
acids by hydrolysis to form micelles
by lipases in lumen

Transported to ER for
Enter enterocytes
conversion of micelles
into triglycerides through diffusion

Move to Golgi complex

to combine with
cholesterol &
apoprotiens
 Steps of
Absorption
Of LIPIDS.
 Lipid Transporatation
Move to Golgi complex
for conversion of Form
micelles to triglycerides
for diff. functions
chylomicrons

Fuse with cell

membrane &
released exocytosis

Enter lymphatic Proceed to

system BLOOD stream
 From the micelles fatty acids ,
Move to Golgi complex
for conversion of Glycerides,sterols and fat Form
Soluble vitamins re-
micelles to triglycerides
for diff. functionsSynthesize in ER to get
chylomicrons
converted into very small
Fat molecules called CHYLOMICRONS
Fuse with cell
membrane &
released exocytosis

Enter lymphatic Proceed to

system BLOOD stream

Finally to
ORGANS
 Diagramatic representation of Lipid
digestion, absorption and transportation
Gal bladder
Gal bladder

1. Bile salts emulsify

Dietary fats in small
Interstine, forming
Mixed micelles.
 Gal bladder

2. Intestinal lipases
Degrade triacylglycerols.
 Gal bladder

Small intestine

3. Fatty acid and other

Breakdown products are taken up
By the intestinal mucosa & converted into triglycerols
Gal bladder

Small intestine

Intestinal mucosa

Apo C-II

4. Triacylglycerols are
Incorporated, with cholesterol
& apolipoprotiens into chylomicrons
Gal bladder

Small intestine

5. Chylomicrons move
Intestinal mucosa Through the lymphatic
System & blood stream
Apo C-II To tissues.

Chylomicron
Gal bladder

Small intestine Lipoprotein lipase

6. Lipoprotein lipase,
Activated by apoC-II in
Intestinal mucosa The capillary, converts
Triacylglycerols to fatty
Apo C-II Acids & glycerol

Chylomicron
Gal bladder

7. fatty acids enter cells

Small intestine Lipoprotein lipase

Intestinal mucosa

Apo C-II

Chylomicron
 8. Fatty acids are oxidized as
Fuel or reesterified for storage.
Gal bladder

Myocytes & adipocyte

Small intestine Lipoprotein lipase

Intestinal mucosa

Apo C-II

Chylomicron
 I Hope I could make your
concepts clear regarding the
Lipid
Digestion,
Absorption &
Transportation.
THANK YOU