KS BETA-LACTAM.

1. Nguyn liu chnh iu ch penicillin bn tng hp: 6-APA.

2. Nu 2 giai on ca qu trnh iu ch penicillin bn tng hp: ct penicillin
to 6-APA. Acyl ha 6-APA to penicillin bn tng hp
3. Nhm chc no ca amoxicillin c cho l gip ks ny bn trong mt acid
d dy: NH2

KS AMINOSID

1. Phn bit streptomycin v Dihydrostreptomycin bng thuc th:

A. Fehling
B. CuSO4
C. FeCl3
D. Nyhydrin
2. Khng sinh no tng i t c vi tai:
A. Streptomycin
B. Amikacin
C. Netilmicin
D. Gentamicin
3. Aminoglycosid c th b bt hot bi enzyme ngoi tr:
A. AAC
B. APH
C. ANT
D. AAP
4. Phn ng sakaguchi dng pht hin:
A. Nhm NH2
B. Nhm OH
C. Guanidin
D. Ose
5. Khi th v tr no th rt c khng dng ng tim, ch dng ti ch
A. 4,5
B. 4,6
C. 3,4
D. 3,5
6. Khi th v tr no th c tc ng ton thn:
 A. 4,5
B. 4,6
C. 3,4
D. 3,5
7. Thuc th no c dng pht hin nhm amin trong aminosid:
A. Ninhydrin
B. 2,7-dihydroxy-naphtalen/H2SO4 d
C. FeCl3
D. Tollens
8. Thuc th no c dng pht hin phn ng trong aminosid:
A. Ninhydrin
B. 2,7-dihydroxy-naphtalen/H2SO4 d
C. FeCl3
D. Tollens
9. Aminosid no c th dng ph IR nh tnh:
A. Amikacin
B. Spectinomycin
C. Toramycin
D. C A v B
10. Aminosid no c th dng ph 1H-NMR nh tnh:
A. Amikacin
B. Spectinomycin
C. Toramycin
D. C A v B
11. Thay i th Kanamycin A chuyn thnh Kanamycin B:
A. 1 nhm NH2 thnh OH
B. 1 nhm OH thnh NH2
C. 2 nhm NH2 thnh OH
D. 2 nhm OH thnh NH2
12. Khi bt. Th Kanamycin B chuyn thnh Tobramycin:
A. 1 nhm OH
B. 1 nhm NH2
C. 2 nhm OH
D. 1 nhm OH v 1 nhm NH2
13. Nhm khng sinh no t xi IR trong nh tnh:
 A. Beta-lactam
B. Aminosid
C. Cloramphenicol
D. Tetracyclin
14. Khng sinh no trong nhm aminosid chuyn dng tr lu cu:
A. Streptomycin
B. Spectinomycin
C. Neomycin
D. Amikacin
15. Streptidin (streptamin) (desoxy-2 streptamin) l genin ca:
A. Streptomycin
B. Spectinomycin
C. Fortimicin
D. Cc aminosid khc

KS TETRACYCLIN

1. Cc khng sinh sau y c tnh cht km khun liu iu tr ngoi tr:

A. Tetracyclin
B. Doxycyclin
C. Minocyclin
D. Oxytetracyclin
2. Dng no ca tetracyclin c tc dng: t trin
3. V sao ks nhm ny km hp thu khi dng chung vs thc n: v to phc
chelat vi ion kl trong thc n
4. Sp phn hy ca tetracyclin trong mi trng kim l g: anhydrotetracyclin
v isotetracyclin.
5. Nhm no c tnh cht pht hunh quang trong mt kim: cyclin
6. Lu khi s dng tetracyclin: khng dng cho tr em di 8 tui.
7. C ch tc dng ca tetracyclin: cc cyclin kt dnh vs tiu th 30s ca
ribosom -> c ch tng hp protein.
8. Khng sinh no sau y dng tr H.pylori:
A. Tetracyclin
B. Doxycyclin
C. Minocyclin
D. Tigecyclin
 9. Thuc la chon u tin cho trng hp tiu chy du lch:
A. Tetracyclin
B. Doxycyclin
C. Minocyclin
D. Tigecyclin
10. V sao khng dng doxycyclin hay minocyclin tr HP: v thuc hp thu
tt nn nng thuc khng ti ni c HP
11. Thuc ch nh c bit vi mn trng c:
A. Tetracyclin
B. Doxycyclin
C. Minocyclin
D. Tigecyclin
12. Thuc tt nht trong nhm cyclin tr vi khun ym kh: doxycyclin.
13. L do tetracyclin d to phc chelat vi ion kl:
A. Nhiu O-ceton
B. Nhiu OH-enol
C. Nhiu OH-phenol
D. C A v B

KS MACROLID

1. Do km bn trong acid nn erythromycin mun ung th phi: s dng

dng mui, ester, vin ung tan trong rut.
2. Phn ng vi cc cht sau y xy ra do phn ng 2-desoxy ngoi tr:
A. Xanthydrol
B. HCl
C. H2SO4
D. Anisaldehyd
3. Phn no sau y khi thiu s gim tc dng ca macrolid:
A. Nhm N(CH3)2
B. Nhm C=O/C10
C. Phn t ng
D. Vng lacton
4. Dn cht no ca erythromycin hp thu tt nht qua ng ung nhung gy
suy gim chc nng gan:
A. Base
 B. Ester
C. Estolat
D. Stearat
5. Khc bit trong cu trc ca spiramycin v erythromycin:..
6. Dng no ca Erythromycin khng hp thu d dy:
A. Base
B. Ester
C. Mui
D. Mui ester.
7. Thuc no phi hp vi metronidazol tr nhim trng khoang ming:
A. Erythromycin
B. Spiramycin
C. Clarithromycin
D. Roxithromycin
8. Khng sinh no gm 3 heterosid c cu trc rt gn nhau:
9. Khc bit gia cu trc ery v clary:
10. Tnh cht khng phi ca Azithromycin:
A. Dn cht methylated oxime
B. Vng lacton 15 nguyn t n N trong vng
C. M rng sang gram m
D. Kt hp cao vi protein
11. Vai tr ng ca ceton -C3 (mt phn nhnh ko di thn du tng, methyl
ha OH-C6, C11-C12-carbamat) ca telithromycin:
A. Gim khng thuc
B. Tng s gn kt thuc vo ribosome
C. Tng tnh bn trong mt acid
D. M rng ph khng khun

SULFAMID

1. Sulfamid ton thn c c im ngoi tr:

A. t lin hp vi protein
B. Lin hp glucuronic nhiu
C. L nhng sulfamid th h u
D. t gy kt tinh thn
2. Sulfamid tc ng chm c c im ngoi tr:
 A. Hp thu chm vo mu
B. Kh nng lin hp vi protein ln
C. t b acetyl ha
D. u c cha trong phn t nhm CH3O
3. Bactrim l ch phm ca:
A. Sulfamethoxazol
B. Sulfacetamid
C. Sulfadimetin
D. Sulfadiazin
4. Sulfamid c tc dng trn virus mt ht:
5. Sulfamid c nh hng ti vi khun ng rut nn ung thm men tiu ha
v ung km B1:
6. Sulfamid lm gim hp thu acid folic v digoxin: sulfasalazin
7. Sulfamid lm da v nc tiu chuyn sang cam: sulfasalazin
8. Thuc chng lao c th lm thiu ht vit B6: INH
9.