Name of Drug Dosage and Mechanism of Action Adversary Contraindication Nursing Interventions

Frequency Reaction
Generic name: Dose: Bactericidal action against Blood: Post-surgical Use cautiously in patients
Ampicillin 500mg sensitive organisms; inhibit Anemia, procedures with other drug allergies.
synthesis of bacterial cell thrombocytopenia,
Brand name: Frequency: wall, causing cell death. thrombocytopenic Hypersensitivity Have the patient undergo
Antibiotic Every 6 hours purpura, to penicillin, skin test to drug before 1st
Penicillin The addition of sulbactam, eosinophilia, cephalosporins, dose.
Route: a beta-lactamase inhibitor, leukopenia. imipenem, oe
Classification: IVTT to ampicillin extends the other beta- Before giving ampicillin,
Anti-infective spectrum of ampicillin to GI: lactamase ask patient if he’s had any
Intraabdominal, include some beta- Nausea, vomiting, inhibitors allergic reactions to
gynecologic, lactamase producing diarrhea, glossitis, penicillin.
and skin- organisms; inhibits stomatitis.
structure bacterial cell wall synthesis Tell the patient to take
infections by binding to one or more Local: medication exactly as
caused by of the penicillin binding prescribed.
susceptible proteins (PBPs); which in Pain at injection
beta- turn inhibits the final site, vein irritation,
lactamase- transpeptidation step of thrombophlebitis.
producing peptidoglycan synthesis in
strains. bacterial cell walls, thus Others:
inhibiting cell wall Hypersensitivity
ADULTS AND biosynthesis. Bacteria (erythematous
CHILDREN eventually lyse due to maculopapular
WEIGHING 40 ongoing activity of cell wall rash, urticaria,
KG. (88lbs.) or autolytic enzymes anaphylaxis),
more. 1.5 to (autolysins and murein overgrowth of
38. (18 hydrolases) while cell wall non-susceptible
ampicillin and assembly is arrested. organisms.
0.5 g sulbactam
to 2 g ampicillin
and 1 g
sulbactam) I.M.
or L.V. q 6 hrs.
(maximum
dosage is 4g
sulbactam
daily)

CHILDREN
AGES 1 YEAR
AND OLDER:
15 mg (50 mg
ampicillin and
25 mg
sulbactam)/ kg
I.V. q6 hrs.