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    Certain liver disorders affect specific genders, like primary biliary cirrhosis primarily affecting middle-aged women, while autoimmune hepatitis affects young to middle-aged women. Dubin-Johnson and Rotor's syndromes typically present with asymptomatic jaundice in patients in their second decade of life. Gender predisposition occurs in some disorders, and Gilbert's syndrome has a male to female ratio of 2-7:1. Hyperbilirubinemia can result from overproduction of bilirubin from increased unconjugated bilirubin, impaired conjugation of bilirubin, impaired uptake of conjugated bilirubin by the liver, or impaired excretion of conjugated bilirubin into the

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    Certain liver disorders affect specific genders, like primary biliary cirrhosis primarily affecting middle-aged women, while autoimmune hepatitis affects young to middle-aged women. Dubin-Johnson and Rotor's syndromes typically present with asymptomatic jaundice in patients in their second decade of life. Gender predisposition occurs in some disorders, and Gilbert's syndrome has a male to female ratio of 2-7:1. Hyperbilirubinemia can result from overproduction of bilirubin from increased unconjugated bilirubin, impaired conjugation of bilirubin, impaired uptake of conjugated bilirubin by the liver, or impaired excretion of conjugated bilirubin into the

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    5 views1 page

    DD 3

    Uploaded by

    GOT7 for 7
    Certain liver disorders affect specific genders, like primary biliary cirrhosis primarily affecting middle-aged women, while autoimmune hepatitis affects young to middle-aged women. Dubin-Johnson and Rotor's syndromes typically present with asymptomatic jaundice in patients in their second decade of life. Gender predisposition occurs in some disorders, and Gilbert's syndrome has a male to female ratio of 2-7:1. Hyperbilirubinemia can result from overproduction of bilirubin from increased unconjugated bilirubin, impaired conjugation of bilirubin, impaired uptake of conjugated bilirubin by the liver, or impaired excretion of conjugated bilirubin into the

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    of 1

    Primary biliary cirrhosis - Middle-aged women

    Autoimmune hepatitis - Young to middle-aged women

    Dubin Johnson and Rotor’s syndrome - Patients present with


    asymptomatic jaundice, typically in the second decade of life

    Gender

    Predisposition by gender occurs in certain disorders

    Primary biliary cirrhosis - Middle-aged women

    Gilbert’s syndrome - Male to female ratio: 2-7:1

    MECHANISM

    stool dark

    Intestinal flora also degrades bilirubin into urobilinogen, which is


    reabsorbed and excreted in the urine, turning it dark as well

    Unconjugated bilirubin binds to serum proteins and does not follow the
    abovementioned pathways

    In unconjugated hyperbilirubinemia, neither dark stools nor the presence


    of urobilinogen occur.

    Hyperbilirubinemia may result from 4 primary mechanisms:

    Overproduction of bilirubin, which results in an increase in unconjugated


    bilirubin (ex. From massive hemolysis)

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