Occurs in second and third trimester

Resolves after delivery

Cause unknown

Probably inherited

Can be administered by estrogen administration

Other causes

Total parenteral nutrition (TPN)

Non hepatobiliary sepsis

Benign postoperative cholestasis

Infiltrative diseases

Tuberculosis

Lymphoma

Amylod

Paraneoplastic syndrome is associated with a number of different malignancies,

including:

Hogkin’s disease

Medullary thyroid cancer

Wave Test. Ask the patient or an assistant to press the edges of both hands firmly down
the midline of the abdomen. This pressure helps to stop the transmission of a wave
through fat. While you tap one flank sharply with your fingertips, feel on the opposite
flank for an impulse transmitted through the fluid. Unfortunately, this sign is often
negative until ascites is obvious, and it is sometimes positive in people without ascites.

Non-neoplastoic (benign) causes of extrahepatic cholestasis