UPH654

KNOW YOUR MEDICINE

CASE STUDY

FACULTY OF HEALTH
SCIENCE UITM

LECTURER’S NAME NUR SABIHA MD HUSSIN

NAME NUR DIYANA ASYIQIN BINTI KHAIRI

STUDENT ID 2020859574

CLASS HS2454C
INFORMATIONS ABOUT PATIENT
Name Of MR . K
Patients
Age 52 years old
Weight 72 Kg
Height 170 cm
BMI The formula of BMI = kg/m2

BMI = 72kg / ( 1.70 )2

BMI = 72 / 2.89
BMI = 24.91

BMI status = Healthy weight range

Past - Levothyroxine sodium

medication - Lansoprazole
list
Current - Perindopril Erbumine 4 mg tab
medication - Simvastatin 10 mg tab
list
Social history - Government worker
- Married
- Male
- Has family with the same mental illness
Past medical - Diagnose with thyroid
condition - Gastric pain
Current - Hypertension
medical - High cholesterol
condition
 Informations about Medications
Generic Name of Perindopril Erbumine 4 mg tab
Medicines
Brand name of Provinance
medicine
Specific Hypertension
indication of the
medicine
Strength of the 4 mg per tab
medicine
Dose of the Adult: As perindopril erbumine: Initially, 4 mg once daily, may be titrated
medicine according to clinical response. Max: 8 mg daily. As perindopril arginine:
Initially, 5 mg once daily, may be titrated according to clinical response. Max: 10
mg daily. Patient with renovascular hypertension, volume depletion, severe
hypertension or patient on diuretics: As perindopril erbumine: Initially, 2 mg
once daily; As perindopril arginine: 2.5 mg once daily.

Elderly: As perindopril erbumine: Initially, 2 mg once daily, may increase dose

to 4 mg if necessary. Max: 8 mg daily. As perindopril arginine: 2.5 mg once
daily, may increase dose to 5 mg if necessary. Max: 10 mg daily.

Pediatric: Not recommended

Instruction on Should be taken on an empty stomach.
how to take
medicine
Formulation of Formulations of making tablets
the medicine 1) Lactose as fillers
2) Cellulose as disintegrants
3) Acacia as a binder

Route of Oral
administration
Registration 416751
number

Medicine storage Room temperature (Store between 20°-25°C. Protect from light and
moisture)
Contraindications 1) History of angioedema
2) Hereditary or idiopathic angioedema
3) Bilateral or unilateral renal stenosis
4) Concomitant use with aliskiren especially in patient with diabetes
mellitus or renal impairment
5) Concomitant use with sacubitril/valsartan
6) Pregnancy and lactation
Adverse 1) Cholestatic jaundice
reactions 2) Hypotension
3) Syncope
 4) Hyperkalaemia
5) Cough
6) Neutropenia
7) Agranulocytosis
8) Anaemia
9) Thrombocytopenia
10) Cardiac disorders: Palpitations, Tachycardia
11) Ear and labyrinth disorders: Tinnitus
Use in pregnancy Under category D ( US FDA ) : Adequate well-controlled or observational
and lactation studies in pregnant women have demonstrated a risk to the fetus.
However, the benefits of therapy may outweigh the potential risk.
Shape of Tablet ( round )
medicine
Colour of White
medicine
Photo of the
medicine
 References

1) Fleig, S. V., Weger, B., Haller, H., & Limbourg, F. P. (2018). Effectiveness of a Fixed-
Dose, Single-Pill Combination of Perindopril and Amlodipine in Patients with
Hypertension: A Non-Interventional Study. Advances in Therapy, 35(3), 353–366.
https://doi.org/10.1007/s12325-018-0675-3
2) Hodzic, E., Pecar, E., Dzubur, A., Smajic, E., Hondo, Z., Delic, D., & Rustempasic, E.
(2020). Efficacy and Safety of Perindopril in Patients with Essential Hypertension.
Materia Socio Medica, 32(1), 4. https://doi.org/10.5455/msm.2020.32.4-9
3) Morgan, T., & Anderson, A. (1992). CLINICAL EFFICACY OF PERINDOPRIL IN
HYPERTENSION. Clinical and Experimental Pharmacology and Physiology, 19(S19),
61–65. https://doi.org/10.1111/j.1440-1681.1992.tb02812.x
4) Mims Malaysia : https://www.mims.com/malaysia/drug/info/perindopril?mtype=generic
5) Medscape : https://reference.medscape.com/drug/aceon-perindopril-342320#0
6) U.S. National Library of Medicine. (n.d.). Perindopril: MedlinePlus Drug Information.
MedlinePlus. https://medlineplus.gov/druginfo/meds/a602017.html.