Biopharmaceutics 2 Marks Solution Carewell Pharma

Page 1 of 19
Carewell Pharma - A Family of Learning

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2 Maks Most Mpotau qestins
Dufin Riophamacewtica
Abtophion
Non-1one ifosim
DfindDtin
a
Distibuion Pasaive), Atirc
Defi Dfiu
rm
facilitatt dlfuim
Dufius (Inhacellulov) tanspouh
DeH Endoutosis Pinocytosts +Phagputo sis)
ha
Defin Poe trausport
DfinDefi Ton pair ttanapovt

lP
Defi Defin Appanent volunu Of Distibuhion and as siqificancuL
tnumuals th touts ofF obcorphim

el
10 Nom t non per ovo extra vaswlav roufts of Absorptton

02fHms scuu peymtobilil.
ew
Defius plasma and -Hssuu prokin binding of drug

drugs.
protun daug bindiug
ar
(9 Defins fuip -fiop muthod n Ev. admiistohion.

C
Duftn )- patition hypotheis
Dufis (Dispositim)-
on-Biopawsfornmatim + Exoehm
DeFiuL Elimination
Defin Renol exuetion

4Tofal body Clearanc
www.carewellpharma.in (free notes)

Provided by :- Jaspreet Kaur
Page 2 of 19
(19 na OF Non- venol rouHs exoehion
of dug
Definu th m
i) Rioovailabilit
) Define Bioeguivaln studits
quauu oou v)
lohin
a
) TVIVC
rm
(iv)) Dilf. bl Abcolut Relativt bloavailalesli
2 Dufin phamacokinuhie Moduls
ha
Defi
Companliut moduls
Non Conpaamunt moduls

lP
Ont CompoarnunF modls
Two Conmpomu open modl

el
2 Dufia u phoamacokiuic pananuhe -
CMax Va Cle
ew
tmox
AUC
- Ca
ar
Dalayud dispiburion modets
Wha l Soft dugs

C
wha toxitloqia achivahion
tumratu bioloqicol facos afcching biotransfor matton.
2 Diswss BCC clamfiahion
2 Defina Statichical MOmnts

Page 3 of 19
a
Deff
(3 b biophanmacouhics and dino linicol phamocotintica
rm
eqvahjon.
Deft Noyu+whitnuy
Michealls men
ha
wrie eqvation.
Describa hupatie cknant

lP
factor aus of non-iua kinahca
Equahon ndy Bpa dau Conc

el
36 ipinskis rulu of five

ew
Relahon b/w Mooconatonls hypid costants
Ditf blos loading dou maintnanu dosus

ar
Defi Agnir Nelson milhod

C

Page 4 of 19
BiOPHARMmACEUTICS - 6ASEM
SOLUTIONS
a
2 MoaksVey shour Awswe typa)
rm
OBiophavmaceuti
T is tu tudy oF th chunical
ha
and physical factors tha atfeects H rak and
amoUn of Kug -Hhat Cachis yste

lP
irculanio
00
el
dsuos
cou tat affci t
oophm
ew
ftbsorphon
T procaAs of MOvemn of unhanga

ar
drug tom sits of admjnistoton to tL

Sustonic cirwlnn
C
ftbsorphon of (Yup) pPm oal ur

Distiburio
T move manF
of du fom Systtnic

Page 5 of 19
dulaion nto diff-dtt Compoatmnt ( body' 04ga)
i.. LungA, kidy, tHea, lveL ee..
Con osibl
a
-ww
ttawfea of dug blood to liel -
rm
ThhacellulL raupouF >
hi vawspout, druq Svbsfanu
ha
rans pouted4 ivto Cell tprovgh mmbran
lP
Pairefrans po o nouln as NOn-lonic difunin
diHuim,
almost 907. dwg follow tu Man m
el
iu ropot dug svbsanu u easly kach

ew
ciruladhon by USingConch qadient

H
AHve ranport
n this transpovt
-
ar
Drug subatant
MOve Syskemic irwlahm aqolnAFt
Cone - g
C
qvadiet wlth hulp of

Tons, lang9 -Aotetrt prokin Conplux suqan. a
rans pottd

Page 6 of 19
facaluhae dilfotm
mov auoss
a00s
drug. molewlus
Th thu transpod,
buF with th lp of
th (onuntodion godien.
a
Carler bodi es|
why al.o
hal'
rm
mudioed panspord
Tt works or a mud
ToAj
rai an t simp pasi dfvsion
ha ,
Cq ty of glucosu into RC.
absorphn of vit. 4 8
lP
Endocutosuu
Tn tutpanspot, dnugs o ve laAg Mz

el
9u tranpoutcd enqulfmu by_cell mmbrand.
uptalke of langa mskIcuud

fat+Atmth
ew
coil Aolubla utanius (A,0,E PU dwq Aah Dalio

ar
paspon
Pou Pou
Calud Conwctive awpo
C
TF nvolves tL bsorpim
weg ou nelutulon aza nn Boluhl_dugb
Uka, waet Sugan asgh Navrod, aqueas chahnls
po Cpusktn chod) m
tu miunovanL

Page 7 of 19
a
Appa volumu of duhibuhM
rm
s duind
datind a ypotuhical volum
dissolve
of bod ftuid ino widh druq
dicbibuk.
ha
lP
AmoaF of dug in tuu body
tppe Valuns d
dsbibuim Plasma dAug ConCovaian
el
Va
ew
C mL/L
ar
(T
C
(T, ELf. et-)

Page 8 of 19
tumro tu (roatis) offbsorption
Eera rouky Panuea
a
Ovally, Suttal V, L M, pausdnmol
rm
Sulliguod, Recta Subwtavs Tnhalatiam
Non-pL KDaa Vasulon roull
MA
ha which oth
lP
Bucal tou, Sublinqual, Nasal Topical
Wta MUSulan, ek
ubutamass, Rectal rouli Vaqino ek
el
Tiss parmuabil
ew
oii oft a dug vossanu
0os manblaW Of issu (cd)

ar
dupmds m phusiocku|
Gpopties of daug
teke MA.Ci2A Pka /» paittHin Cacficde.

C
physioloqia bamiesOR0 placanta elt..

Page 9 of 19
Ploma
proteln -dug Tiss &Aug
bindina bundih
(exbavakcuan
L bud wit Dugs bino to
playma appaun
a
pAettins inuds issuu) hurt lonq
diubiowhn
rm
Systunic Voluh
of
Ciulahm (blovd )
Tinvolvts wta bom tvolvinvolves Abmg a4

Kesid Covalun bad thus
aDug Albm
ha vea, Cidy.Us
lP
(C
(4lip fop mukods
el
Ratt o obophon Abweton thi

elunahon
ew
pH- pahihn hypotiuy

ar
provida a Dac fran wok fo

Undnstandi ng duug ab&oftion.
C
Ca to t,
dau subfa C of Ma.wig qRualn an loo,
whidh L Pima Taspod a0u bjonnlnbrah
pame difuin qovemid y

Page 10 of 19
dunociahim Conatant (pka)
upi Aolu
bl du
pPH
a abionpim sl
a
Dupouhon
rm
Th prouA a Hend to lowe
PlaA ma Conc duu
ha
YUuh
lP
Diübibuhon Pureblu raf of a dug bl
ConbandT (oo)
Eliminaham) pom tu
Zvrtniblu lo of diug
el
body
ew
iopofomain
ar
C

Page 11 of 19
OIine Elininalian
i delincd a Ahe IatNIYSiblc móa
al
he
badhF
a
Rliminadian
rm
imialian
ia-lanarmaiian LYAiLon-
IOne Renal
ha
celion 6 talbody deazantz-
lP
Ke na
xlion ideined_as ihe uolume
Dlaoc dx blasma ahih i
Lomplilleataa he unchantd
r
el
Unit hme
aidniy
Renal Eudfon Rataaaliminat fon.hu d
ew
1laima daugconc
laal Body_clearanuahen badylid(oniainin

ar
dzug am day is nih

Atma \ie dcomplelelyiSße tiipeiad- imt
C
fiminale kai
lug plasma (on>

Page 12 of 19
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YouTube
i_amt oon-1tmlaule u
Ludion-
aihe
ns lhe at ihe ouleo tiian mihy-
dug 01tinLIL led
icyIh
a
rm
ad inoniuiinal uudion
GnidatLuLiion-
LILA1on-
ha
aluaay
Kul monany iLiion- -
Glandular uLlion-
lP
ShinRLLILiion.-
Dint Biotquivalintt studias

el
ansn_whfth he_dug substante inRs-

m idniitaldalagcJom athis ihe-
ew
SslmithulaiionaAh
Slalis
Samt
ale ard dent
ar
iNIVC LIa_uilho In viuo Ca11Llalfon
nsT h is ihe srciappnoach

adsuin-
C
tlalïqnshi
brlwrnainio
0m
lvon_in and

Page 13 of 19
ine þhaama tabineditmodtl.

Y
ing4 aihumaiitally
quaniioliuyhe me Caui
Ahialugh, oufAh boclyandd,
a
meaningul-
J
rm
OR
yfhamáLchin.li i dinas lhsdud
im Lourse daug HOmE
ha
ond hir Yt laiianshib Llh huahruiiu
ad oit a daug
lP
0 he desmai
Lambariment adels= lt_i suallytmhloued
el
mainial in sdami Sut himical

NLLiion bialäaitalNaLLiLL and ita lagiza-
ew
inlii0ciion hy niiT LolleiiAn

yeinlnlinhid
Dy- diintdidt
ar
Non tompar imeni nmodLi t dots nai_auume

ihe numbiy
om iminl uums t fmínafon_
C
a llo2 iri mdir his mtihod is Simale

Ana_ _Lommon lydo Lalulsi.
phox maLohineil aYamini urh_ul
.a
* **, De wle ne bepng tea

Page 14 of 19
a
Date
mdl=tish
rm
CneLompaxim.ni
Simblri
dsibedhe-pxaLss nt. d Thi
ha
in
lumiaion lba didg ah
And
hmcl aLm ihbod And the
ltautiht sngl-
lP
ih
mint-
uhiloim-Lompaxt
me
el
Lamparimeni optn modil lhe

Lu
ew
llauas A
uG (omDalm
dug hato iuo
shasa ihblasmu
hat
DiLMponrh iially a
LonLeniiaiíon dtlints
ar
iatordr bidteAs
heSumolua
dR ttonandlimlmilOn-
C

Page 15 of 19
Y..aaSnaa
la Snaa loneeiainmax amaunt
duq puuntua posma
CCmax)
a
rm
ha
Tvex)
T
nn.ai ad atwheh puaR plasma Coneentua

i
lP
an ü athieued
Auc Auua undu Cuwe, dinu pulacd eu usent
badu
el
e >Aue-
ew
T-
ar
)Ni Apbaunt ualura okistuubudtia u hupathati.ca

AiLALLLLAALat dugdstribulid ubdly
C
aSma binckuatáliaa
h lasoa hali ion iad in ulhieholu
So aolnaiadika- D pedy
Cducation Is UFE t SEU

Page 16 of 19
u) K lbsoxptoa. Nali Conglat, Bat at uslaiola a

-CHuo- ulutoar dyslia
dumea Comhlfl mbNa
a
R-Kunakanuana Ridnuup
Ha
rm
hop.c2ydapddsdibudim.eels
Combautmint madul u. Jhioa dmua paua
Xudies wd
usa Compaudtm.enta.-
nwhOh_alo
set_Aueqsh
Exampli
a noccmlas Zubtancs
nat aaNeSuuiousCautxalucducallay
Supin ils
ha
cte-
lP
Ansi26 ai0alpatcaadUNatiam ALimd dn thu
onditicm Luhun a dxuq üdnministuA
Laahy wel a. iiby y_þxaducuy
el
Acbteusiiaeliam in bady
ns-29Bislogical_faclau uuncunudabalisna
ew
eadu
uanouna
3: Hoxdaona iabalane
ar
nzya itecludjaaiuhbitioo-
ie
Lotin Binoliu
OloR
C
oloaioa
Stiodhai lal saali duua
pna-KIS alasuicatin
Education ts UFC IR SCA

Page 17 of 19
gs
xu a aighSalubilit y pumabilt
las I uitn lausolubili hiqhexm
uClass IL with Hiah alubility ylatuNuumia
bilh
ClaAY_ua uita bw sbelubilkty-y laubexmacu
a
bilitu
dti: Lq Aitiaia Alldlibin
rm
nsulin
N ao
ns29 atiat eal puuhaa l g_qan matnad alLiciion.
Intiuautalin Adlata
ha
aaniug nanLombailaent analygis
_plns-30Siaphamatuiiey uaicah:(aRinii
lP
Alind 43 Suduy und AaudAMudy
laadly
Slaiding dosageoa MEmhumon
Octioa m bialogiea
el
FRs Nays Lauati

ew
-DAK CCs-C
Nh.
fns-2 MichalLs hALnlntauatuaa

ar
Umax C
dt KmtC
C
Aa-33Hupatia lhauant .haual a lomluti

imavaal duq uom NeY
Rngoli
EGucauon Is uFE it sELF (CRRena Cuaranc

Page 18 of 19
n-84 aclasy ausinq Nlon iniaaskinilis

AngAabs.axption u_Anq Mutabolism
maww.c istaubutiea
a
ua Elinainabiom
rm
Ans 2
d
Atad Saion.cuniualia
sionRat
Ttal uaxana- ha
lP
24Kule ea lipinbki a taat
Mw (MolLcula ut ooua nlst hu Saa
el
eaphilidty
-
ew
No. Hbond actstix l6

u No: dH þond donay_
ug
ar
adidlaki
Conolluns auOug tnasalim ab8oxplucn
C
RT
Gducatlon Is UFE It
5
SELF

Page 19 of 19
a
rm
Hna-
Alind a
Aoadiu4 ase
ha Maintainanc Aag
lP
hu. humauy OY- _amount
Aadase aiven in laua hma-|dase tar ig uuauise cdan
und tatbain dtead
ataluiaia teaditat
HaSma okxuq Con.tantuatiao Conaanluálim
el
auioRlu-
na39 lagnu lelaon paad ulund asth nuth.

ew
Aox dilumini RStimation Oug abgant

un
intatal Qmaunt tbe abserhee
ar
C


Biopharmaceutics 2 Marks Solution Carewell Pharma

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Page 1 of 19

Carewell Pharma - A Family of Learning

DeH Endoutosis Pinocytosts +Phagputo sis)

DfinDefi Ton pair ttanapovt

tnumuals th touts ofF obcorphim

10 Nom t non per ovo extra vaswlav roufts of Absorptton

Defius plasma and -Hssuu prokin binding of drug

(9 Defins fuip -fiop muthod n Ev. admiistohion.

Duftn )- patition hypotheis

Defin Renol exuetion

www.carewellpharma.in (free notes)

2 Dufin phamacokinuhie Moduls

Non Conpaamunt moduls

Two Conmpomu open modl

2 Dufia u phoamacokiuic pananuhe -

Dalayud dispiburion modets

Wha l Soft dugs

wha toxitloqia achivahion

tumratu bioloqicol facos afcching biotransfor matton.

2 Diswss BCC clamfiahion

2 Defina Statichical MOmnts

www.carewellpharma.in (free notes)

Describa hupatie cknant

Equahon ndy Bpa dau Conc

36 ipinskis rulu of five

Relahon b/w Mooconatonls hypid costants

Ditf blos loading dou maintnanu dosus

Defi Agnir Nelson milhod

www.carewellpharma.in (free notes)

amoUn of Kug -Hhat Cachis yste

T procaAs of MOvemn of unhanga

drug tom sits of admjnistoton to tL

ftbsorphon of (Yup) pPm oal ur

www.carewellpharma.in (free notes)

hi vawspout, druq Svbsfanu

iu ropot dug svbsanu u easly kach

ciruladhon by USingConch qadient

qvadiet wlth hulp of

www.carewellpharma.in (free notes)

Tn tutpanspot, dnugs o ve laAg Mz

9u tranpoutcd enqulfmu by_cell mmbrand.

uptalke of langa mskIcuud

coil Aolubla utanius (A,0,E PU dwq Aah Dalio

Uka, waet Sugan asgh Navrod, aqueas chahnls

www.carewellpharma.in (free notes)

(T, ELf. et-)

www.carewellpharma.in (free notes)

Eera rouky Panuea

Non-pL KDaa Vasulon roull

oii oft a dug vossanu

0os manblaW Of issu (cd)

teke MA.Ci2A Pka /» paittHin Cacficde.

physioloqia bamiesOR0 placanta elt..

www.carewellpharma.in (free notes)

Tinvolvts wta bom tvolvinvolves Abmg a4

Ratt o obophon Abweton thi

pH- pahihn hypotiuy

provida a Dac fran wok fo

www.carewellpharma.in (free notes)

PlaA ma Conc duu

www.carewellpharma.in (free notes)

laal Body_clearanuahen badylid(oniainin

dzug am day is nih