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Respiration 12 Interstitial lung diseases

Respiration 12 Interstitial lung diseases

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Published by: api-19641337 on Dec 02, 2009
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03/18/2014

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Interstitial Lung Disease
Diffuse Parenchymal lung
disease

Introduction

Interstitial lung disease, or diffuse
parenchymal lung disease, comprises a
heterogeneous group of disorders that
share a common response of the lung to
injury:

\u2022Alveolitis, or inflammation
\u2022Fibrosis of the inter-alveolar septum

\u2022The term "interstitial" is misleading since the
pathologic process usually begins with injury
to the alveolar epithelial or capillary
endothelial cells

\u2022Persistent alveolitis may lead to obliteration of
alveolar capillaries and reorganization of the
lung parenchyma, accompanied by irreversible
fibrosis

\u2022The process does not affect the airways
proximal to the respiratory bronchioles
\u2022At least 180 disease entities may present as
interstitial lung diseases

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