Familija Picornaviridae

*Genus Enterovirus
*Genus Rhinovirus
*Genus Hepatovirus
Genus Cardiovirus
Genus Aphthovirus

Familija Picornaviridae

(24-30 nm)
60

 (30%),
(70%)
- , ,
8-9 kb,
3 - , 5

VPg
- VP1 VP3
,
VP4



(33000; 27000; 23000
6000)






, ,

(, 1949)
, 1-3
(23 )
(1-6)
31 (engl. enteric
cytopathogenic human orphan viruses)

(68-71)

 (+)



72,


, ,
,

(, ),
,
, ,

POLIO VIRUS
1949.

1, 2 3
(MORBUS
HEINE MEDIN)

550 30 min.
UV , .1%



(
)


(HeLa, VERO)



:
-
-

-
3-4





PEYEROVE PLOE

19



(), CNS


IN VIVO



1)
2)
3)
4)
5)


. (
)
. (
,
)
. (
)

:
()

()

18

COXSACKIE VIRUSI
1948 .
COXSACKIE (SAD)

(
)
(23)

COXSACKIE VIRUSI
(6) :
-
-

-
- , ,
,


COXSACKIE VIRUSI
GRUPE A
HERPANGINA (2-6, 8, 10)
ASEPTINI MENINGITIS
(2, 4, 7, 9, 10)
PARALIZE (RETKO) 7 i 9
EGZANTEM (4-6, 9 i 16)
PNEUMONITIS
NOVOROENADI (9 i 16)
HEPATITIS (4 i 9)
BOLEST AKA, STOPALA
I USTA

COXSACKIE VIRUSI
GRUPE B
PLEURODINIJA (1-5)
ASEPTINI MENINGITIS (16)
PARALIZE (RETKO) 2-5
OSPA (5)
PERI I MIOKARDITIS (1-5)
HEPATITIS (tip 5)
NEDIFERENCIRANA
FEBRILNA STANJA


1) -
2) (
)
3) -

4)


5) - COXSACKIE
VIRUS GRUPE B

6)

7) COXSACKIE -24


) (
)
: , ,
,
)
(, )

- 100

pH< 6,

()
,


33

ORTHOMYXOVIRIDAE
( )

:, , 80-120nm
: , (-) ,
, (8 ) 5x106 D,

: (1%), (73%),
(20%), (6%)
:

ORTHOMYXOVIRIDAE

:
() (N)
: ,

:


:
1) (1, 2 )
2) (NP)
3) ()
4) ()

, 550
, 16
5) (N) (
450 ..), 9

 (1-3) N (N1-N2)

: DRIFT IFT
:


,





( RNK II)
,

1-4
()

(
-)
REYEOV SINDROM (
)

: N

:


IgA

: DCK
( ) LLC-MK2 (
)


:
-
(RIH)
- RVK, ELISA, RIA
-



,


-
,
(
15 mg )


N
-

PARAMYXOVIRIDAE

(gr.myxa-sluz)

ORTHOMYXOVIRUSIMA
MYXO VIRUSA

1-4 ,
,

,
,

RNK RNK

8

9 nm

18 nm

RNK

PARAMYXOVIRIDAE
: , , 150-300nm
18nm
: (-) , ,
5-7 D
: (1%), (73%),
(20%), (6%)

PARAMYXOVIRIDAE
:
: HN
(F)
:

VIRUS MORBILA

PARAMYXOVIRIDAE
PARAMYXOVIRINAE
ROD RESPIROVIRUS (virusi parainfluence 1 i
4)
ROD HENIPAVIRUS (Hendra I Nipah virus)
ROD RUBULAVIRUS (v. parainfluence 2 I 4, v.
mumpsa)
MORBILLIVIRUS
PNEUMOVIRINAE
ROD PNEUMOVIRUS (RSV)
ROD METAPNEUMOVIRUS

N

CD46 MO
-

 :
,

MORBILI (RUBEOLA)
- ,

,




,

MORBILI (RUBEOLA)
1)
,


2)
RES-A
3)
(,
)

KOPLIKOVE MRLJE NA
BUKALNOJ SLUZNICI

MORBILI (RUBEOLA)
CNS-a ,
1:1000


(SSPE)

SSPE

MORBILI (RUBEOLA)



(
)

1) (
, )
2) (

)
3) -
(RIH, RVK,
NEUTRALIZACIONI TEST)

,




- ,

MUMPS VIRUS
()
()



, , ,
30%

MUMPS VIRUS
()

,

20% 13 .
( )


(
1%)
: , ,
,

: ,
( )
(RVK, RIH, ELISA)

MUMPS VIRUS

: ( ),
(R)
(MMR)