Crnt-

* Alka/ods
Demien-
Alkaloids ane merturul OCCOTmg mitogem
COntammg Osgenic (onpoud3 wit e encePtien Ob
Ominno acid Peptida nd derrhcH ves, Pines, arrimo Sugo
Ond artbiottc3
MesTe imtodute thetemm al ka loio whych uess
detmed
as asic
mitog Cenrtaimimg Cempoumd 1SDqT
ISolqtedd

o plapts.
Allkaloids Ce deyirmed CS basic mitogen Cetamnmg
meturu Producs, masty Optically crqctve amd passe8ima
mitogen heteole as the. Stetral nt and hauis
a
PronaUnced phy siological actten
e m e ceptHons ctw givon here- bchicne is hd ag
m allkaloid which is mot mitaogon hehocyle
TKlamim mot Censideed a an alkaloid becaucse itSs
UniveSaly dishiadted athogh H Corten hetvocyc ba

NeOnclature
L a s t Coses alkaloids an2 cemoted by
i ' i a l ames which c mosty emsl m Tn Coge e
Several digoenant al Kaloid Occorst 1mh S c n PloMt
he Sulo*-ldime, -mine, alie, -Imie a e added o he

Prcipal rarme
alkaloids ae derved rom botanical
T h e mame oU a s t
mame o h SoUrte plan eaPapcavem
2eme alkalejds deve brOm t e phySiological actten ~
morphme
OccwreNce - mast alkalotds aceim bíora , imanimal.
The mo Strcttrally difteent alkalocds is esttmaled
to he aNOUNd 6ovo A[Kalordg a OCCO m Saveral
Pot et haPlo- Tn &ee CoseclRalords have bov
y
octfecrom alt ha Ports Plont (-P:paver Smmrm)
othe/er ca,fhae have aem omd omly im r a Pre
e fe calkakoidls Aphalandha o

dolizdim
*ex toucten, isolaferti@n, Phyaoldtical dctien and Fole o
afkalods m plamt m book13-1967
Hygotme
CLassibicatien dAlkaloids
Suolmsenme
Thc cuRaloids Can e cosibted chemniccy
Nicotte to meoA
cop accosdim ohe matuv oy rueleaus Preest he
cullRaleid. Coceine
d m e group- Piema, Cemmme
Pdmrol idime Ph

pume -Aopine Cocaime

Hygme

OH H dH

herontherey Mophime, Herbi , Co ceime

CHO-
cheical Methed oShekre delenionaten
Dovble
Nemly
dedemmne Temeral
)Moleclo
&pechoseN
cro
t
thor alkakoids
pend ha y SPectrosoP mtod ar nøt
wel ano
tefore
by Aleed chemical Method
Sobiciet decrese
They o

o he wctune meeol
to by mfta.s(S
be coirm by
taKen
pe Cemetal mafher
a
eq0ivalends
Mole
cre

orrulu
qualittte
place
deleronimatten
ole
bomola
im
CPDE)
amedysis
give
do
6omu
commPond
omaienby
ater
no
tog T+ is v mp imlyormution te
doy
DBE Cam be calcota e dd oy CHe
acbau
e
Cm
twoH
DOEa
db
y
 bond3- 3
- Mu Hple
Ba

|Ha CH - CH
Co- add'htn Produc wIP
Ptper acid fosm eha bOmo -

fm ccly how te preremce ot two double hond3.

Sx
Ryd,oxy bem20Ae by
eponrton a c e t a t e
cihori de
rea wih Cc4 thloria / benzoy
reaHg Co
CHcoc R-o -E-cm
R-OH
Phcoc RR -0--ph

Onmine adso ve -
RNR ACoc 12-H co
R
No o oH - aceta le +reqed woith alkanne hydrolys
mo o H is eqal to amoUt db al lkult nsUmasd

Preol/alkokolic phemol ara de'sso leim aon md goma

la u4 whch com be upreclpitat
wh CO

NHON O
OXt'N

Cuodoorylic acid- Rc O0H latco RcoOnla t¬a tho

A RCOOAlA
 the e AlaoH
fss dotemmine by AlaOH
Ob -Coo n
o

No
Conred loy oe Co0n 9Up

CCoboxylc ocld deuvcrtHe

e3te Ond midR
PoeRnce d
hop is Co-trmad by th hydoygls o tha Compoud
nd amalyainq th Produt
er atopine wheeacted wiH Ba(ot)a Yield hovi c

acd md a ctlcohol (topiro) So itto be on

Aludl
RCoOR'+HaO RCOOM A'bH

Metnoy ChroP-
Roch ROH CHh T 9 ) AT Crpt)

onst alkaloids have N o

hetaceli Syslem ohre M rs Praert es mime
-AI CTR-NHC R N CCH), T
-lHa
total 9 CHI
2CI
KNCEM)
N C CHhT
R A
(2
 C md Mhod R-NH R4Ko A + Ofto Podo
A

Aa: Ra ChH +0the Prodye

R-AlCCHa Aa ko
(LHB nIH +Ohe Product

eod- N-C
3 d

rt-C% HT NH-CT
Degordat en Alkaloids
or he 3oeton dafermimaio
( Ha omm ELiomtraGn
CSeplneHod or suctu e
elvcidaton al kloidg Aninas OS
a healed wt
Meth lodide lo get querc comonium jodido3
tohich are conveuted to huproxide by w h Aot
tseate
h de compoSe on autt a+ 200c to Yield al kone

C) C T
+CH

Ptpuridine

Ago Ce

Co
Emde s deqaondatien. alkeoids do
o r fha
nO COmtcan P-H
rohtmam nehod beato fetva hdroquimolne
CI tCOM
N
Cr

nde eHrod.
CHbT

H CHT
Cb

Ao
Hobo

Sye
-Cs

Sep
e. C crb
 Phcoc

Co Ph r-B
Ph

Drst

pheN
ReducHe desoadaion-
Reducion on al kako id
Cwith
wi Hat 300° is Usef o
ve krowin 3ekON

+N NH
HI
H
T 30C

z n dst dstlatien-
2m dut

So 6nwber Ki Preen

6 bn Ju9 r e
 CONTINE

H
Hembck is a miay poisonous
plan Hemlak
POemi is due to tte Presemto. dsevoal alkalos
which ceniime s most+
(oiime dahous a 6orm3mpotat
d iye ond Caut dect
by Pavu'ysis.
Cominne we *
alkaloid 4o be uthaaized
Colarles. opttcalu aci4ve
Shrtcture 23tblished Poisonas i d
oy Homamm. RE)
StructurR dede
qiHen
OMolecohoruloa - CgnN
Cenitme +CHT qualonor amoniu Sa
COmiia NO
N is e Sec Cmmj me

cadogenaton -
2m dust

disI N
C9ni i
NCooH
Coyrm PU2 Cbomylic acd
deudopahem os et kellen dr Conite Is
Pydhe Cehe sPuidie dedvatBve rh a-CH
side cam or C2
 T h e Side chai conine Con Jaa n or
(so proRj

)
Comine gie m-octane when e a t d wih Hal algic
Chich wn be otan-ed Goly o m Cop T.

HI
3aD
-oc4eme

N
So Oteme

Hoboms es haustve degordaton

CHaT,ACaRE
AO N
Aja
A
C

-Octoe
C Ven Bvum deqcrdatkon -

Phcoc
NaOH N

Co-Ph

Phcy
Pn
o Shwctte I s Coee

Sotesls-
c
= ANCH
Pdina c Ph

Al ,CattB
caho
ch
Conln

E pherne

E phodaeime s om nnporBot cGns+itueth c e e

dru Ma Huomg TH dise blood persure
0 a
pouRrhol sttonu leu wid LDn be Hkor
Used hor t etnont s
bondtaCthnm
 - i+ is kaevoratator o eHng Wte olld
Molecofon homela oMNo (DeAE)=4

2Kaloton 30
Omdatien with C3gi benzolc cicid
p-dazivutie
uhono C00

E phedntne erolc acd

Cimnj m

HT +CrI
NHCH A
epedie Oamn

phoc
AMc

i s a dibenzoyl douivave beccuse NHC al3o

beoyed 2o O OR Is Pre3ent

Cutio Noe-Ph
Pkocl
q j o No

NHCH

Oridaion gi keon lo alcool

 -o

Hc +CNK

Popio phenone
Po-oP openone Cam h om by two Soctune

NHCh
HC

s Other evi devce is maaded

(6) Hofhmam enhausi ve Mety laton

o
Cy CHy I

Al HC
AgOH

So StwctUe I is Conec
Ths a COtsm
oPtiwllyacfivih ob epkedr

HC
 Synthesi's

CHhAl
ChhoH

pt

+CHhCh No AlO2

ChI
AHC