Fig. 4.

11
Fig. 4.9 Fig. 4.10
Scissors
Blunted and Pointed ForcepS
Curved Scissor Blunted and Pointed

6.5 Mariottes bottle

a steady pressure nead since tho
t Is employed as a convenient device for maintaining
pressure always corresponds to the lower lever of the glass tupe

7.0 Questions
be allotted by subject teacher)
write answers to Q.... Q.... Q.... Q.... (Questions to

1. Name the five equipments experimental pharmacology.

used in

2. Name the five levers used in experimental pharmacology.

recording device.
3. what is thespeed requirement for Sherringtons
4. How the capacity of organ tube is measured ?

5. Name the five parts of organ bath assembly.

6. Which lever is used for experiment of isolated heart of frog
muscle of frog?
7. Which lever is used for experiment of rectus abdominus
8. List five instruments used for dissection of frog9
9. What is the use of Marriott's bottle?
10. What is the use of Symes Venous Cannula?

(Space,for answers
3 0 s soution test appve=
1 y Analyucal Balan te ) pH meler

4 ) Flaume photomelo
Frontal witing Jever
m ple Jpwe
3) Stcwding hecuct Bawe 4) Flxtleves
s)G11mbad Jeve.

he peed
speed A equive merit Ys 01 ,
0.5 0 50, O t 5 ,

MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION 16

 Pharmacology andoxicology (0813)
Experiment No.4

(Space for answers)

he fssve eocuby con tractina/
fsomebic ox T sotonf selaxfng and Can
tacune cuLces s s ea tD neas uee
Jorte x clisplace oent
es P
6 Ffue pasdi o Tganbecth asserob Cu leun,
colon, Vas deevens tracheq, bladled e blood vess els et

G Psolat he cuct TO stoodling Jevex ueel

TheThe Jevex Used or edhu abdominu
Yso tonkc Jeves de ok

8. O f'ssectfon P an

Probes, ecalpel. Froceps s cY'ssoTSd'ssecting P

A Mariott s bottle s A deutce that

eenstunt ekusfon proutdes
velodtu Pquids
10 ACannula Ps a thin Jube hedt
nbo apes ons oloctors ios eedt
body cauuty Such as th
n to a 'vefn. Docto nose
administex USe hemto edrafnude
medicatfon 7
proutde oxugen.

MAHARASHTRA STATE BOARD OF TECHNICAL

EDUCATION
 2. 90 seconds: Allow the drug to contact with tissue.
3. 120 seconds: Give the first wash. (Give three
subsequent washings at
the interval of 1min.)
4. 300 seconds: Give the second dose.
7.0 Questions:
Write answers to Q.... Q... Q.... Q.... (Questions to be allotted
by subject teacher)
1 What is the composition fixing solution used for
of
kymograph paper?
2. How the fixing solution is prepared?
3. Write the time cycle, which should be followed for recording of response.
4. What is contact time?
5. How the magnification is adjusted?
6. By which method the response is recorded kymograph?
on

Write the tension

applied for preparations of guinea pig ileum and frogs rectus abdominus
muscle?

8. Which laboratory techniques you learnt from this experiment?

9. What is the use of Kymograph paper?
10. What is smoking of drum?

(Space for answers)

1 Th's wa Caoiec ouut by CCaull seperctfng he
Smoked
9Smoked papex rom the bumcudtying, the
the moked
papex h both "hands and passfng sloy meuing
he papex in a pUdole x i n g so etfor con sisting

alcobollc gson ' shelfac, Colophony esio or

oh ex Vavehis hing gsoution.

1 .FPxing Agent qsodiurn Cmmonium tnf osuld
diss elves stwer
on exposec siwe
YHadenexPotessiun auan to hcucdun he gelatin
emuls fon nilm.
3.
3
Acioi|fee suLphibicacet acid to vemove any
devetoping
Heseuadcikalintyrom preuous devetoping
3 0 seconds take hhe base ne 'Aecorcl
AMoto he ebuug to contact wlh tiss ve
. q 0 seconds
3 20 eeconols Gve the Prst wash
4 300 Seconde, Gve the Se cen el eos e
5 minulas o n yele 20
MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATON
 Phamacologyand iOXIcology (0813)
Experiment No.5
The me alowed (Space for answers)
o t h fhe tissve
O CcuuLg Terocin n conta ct
Ccule Contact time
5 Acliuut o mcgnifcouflon
Ranting tip and uOum Propeduy b dfstan ce bettoee
ghtinq
tpofnt dnd he
atach roerdt tb he ten te betoe en
tfssves and
and ne he uoumthe
uourn
by aclustinga he eldtfve ePs tan ces desire &egsu
mgnicatfon Ps obtained

The SLesponse Js ecorded

Smopknn2 couuum method. Fymogaph by

Guoea
fleun
pla 0.59m . Frog s HeTun
ab dominus mus de

kymogaph pp ee TsAenexaly tostuc the

wsed
d xenobotres on tssue prepeuattf
fs
s q 9tand alone
on. 1t
Tt
xecovcling Qppeuucius along.ufth the
PPcual Such as
both

o. he prepascoctfon tne
the
smoked pepcper, q0 aat
tsel, Consfsted o wp ptn O blaNk sheet
OVese kymogaph cbuum'and xtng dum Pa
C
q on
borizontel ing stand and ex posfng t to behz
Or Recosene umesn qtham be spect&l made
doT teaMed Smo king cbuun

MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION 21

 ang ORICOOgy (0813)
armacology
Experiment No. 6

Standard Table:
7.0
(Values are in gram/ Litre.)

Composition Frog- RingerDe

Sr. Ringer -Locke Jalon Krebs Function
No.
To provide lsotonicity,
Sodium Chloride 6.5 9.0 9.0
1 6.9 Isomolarity, Contractility
and excitability
Potassium Chloride 0.14 0.42 0.42 0.35 To provide lonic balance
Calcium Chloride 0.12 0.24 0.06 0.28 To provide contractility
3
Magnesium Sulphate 0.28 To stabilize the
preparation.
0.2 To provide alkaline
Sodium Bicarbonate 0.5 0.5 2.1
medium.
Sodium Dihydrogen
0.008 As a buffer.
Phosphate
Potassium Dihydrogen 0.16 As a buffer.
Phosphate
Glucose 2.0 2.0 0.5 2.0 To provide energy.
8

8.0 Questions:

Write answers to Q.. Q... . . Q... (Questions to be allotted by subject teacher)

1. Why sodium bicarbonate is added at the time of setting up of the experiment? Give
reason.

2. What is the function of each composition in frogs ringers solution?

3. State three physiological salt solutions other than frogs ringer solution.
4. What is the use of ringer solution?
5. Which Physiological Salt Solution is used for experiment of isolated heart and retus
abdominus muscle preparation?
6. Which precaution should be taken while preparing the physiological salt solution?
7. What is contractility?
8. What is lsotonicity?
9. Why there is need of providing isotonic solution?
10. What is the need to provide buffer in physiological salt solution?

(Space for answers)

1.Sodium blcasbonte 1s added at the ume o selirg p
h e eXpeimert to proulde alkalune mediun sin ce Calciurn
eabone is teab le to be
Predpfted the Cclcium.
Com p os fton selngers golo incudee
Sodiun cblode To prOuY'de lso tonf'ciü .

MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION 3

 Experiment No. 6
Phamacology and Toxicology (0813)

(Space for answers)

Psonlc balan ce
) Potasslun ehloicl e - To p roufele
Ste Cculcuo chlo/de Toproufde contaca ctity.
J 9oclfum bfcaxbonite-To proulde alkaline mecuurm
o-thex physfo logfcal gat qs ouiion cU Rng g oulien,
De Ualbnsouuon and Koebs soufon.
solution o seveval 6abb dissowee
Rhger's soilon a

tn ooitie t-he pwp0Se o Creattng anisotoric

anoinal.
Souilen uelte to he boc uld & n
6 The ng golulien s vsed solottud heasd and

He lus ablomdnus muste.

61.Wosk aaa should haue sukfdert exhaust veniaien.
R. Avoid ege contact and oecue eut prolecuon.
3 AvoTd en eontact oece befoe closhirq glou
he capabtlity or qUality shinki ng or contaacting
J
Hhe powes k mus clo ib e shortning irdp amere
Compact
8 Tsotonitry s delfned as a con litfon în tohfch the musde
Le maung obe in a xelatively ton stan t tensfon ohl
Jength
chunges
he isotonic qsoution alow the cell to
moe un dee
to oTu and nutienti in and o ut o the cells,

se n physfo logical
to mauntaun
salt soldion athelps
a constant pH

MAHARASHTRA STATE BOARD OF

TECHNICAL EDUCATION
24
ARASHIrn ui
 Fill the observatons irom the
observed CD,
Dose of Adrenaline
Sr. Heart rate
(ml)
No
Frogs ringer
(Beats/min) Force of contraction
Tone
30-35
Normal
0.1 ml Normal

Frogs ringer
0.2 ml
4

5 Frogs ringer
6
0.4 ml

Frogs ringer
0.8 ml

11.0 Conclusion
Therefore, from the observations, it is concluded that
1..
adrenaline causes,
2.
increase/decrease) in heart rate,
3.. * ************
..(increase/decrease) in force of contraction,
increase/decrease) in tone.
12.0 Questions :
Write answers to Q.... Q... Q.... Q....
1. List five drugs
(Questions to be allotted by subject teacher)
having sympathomimetic action.
2. Which type of effect is
produced by adrenaline?
3. Name the adrenergic
receptors present in the heart.
4. Name the cholinergic
receptors present in the heart.
5. Why there is increase in heart rate
and force of contraction?
6. What is Tachycardia and
Bradycardia ?
7. Which precautions should be taken while performing the
8. Name the parts of isolated heart of a
experiment?
frogs assembly.
9. Draw the graph of effect of
adrenaline on isolated heart of a frog.
10. What is your
interpretation from the graph?

1: Druqs hauing (Space for answers)

8mpatn o mÍymee cton
aAdemalihe Me Me tho xamunt Cpinephine
wPhenulephun Pheny pTopanolamine
MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION
31
 Pharmacology and Toxicology (0813) Experiment No. 7
(Space for answers)
TOcui ced by
Sympatho mimdhie
Symp actfon p
Aclernaliny
in he h euct
ecep toy pTesen
3Betq 1

are
the Chloron exgi
chlovon exgut e ceptby
ceptor
us Casuni M Ae

un the heat
present

S Ad eunalune a the Sump adhomimeu dug

cbulg tohi
incT@se
Lohich
Sttmulalusthe
heast
Hheve
thérelove there a
sqncs

contaction.
Yo heat ol 1
alt sis inoua uPon
inOLase
hecud
Ca.cioac -when Tachy
l o c h y eeCUdiac
CUroiac.
achy colled Qs
at s
hovtHal
heat AQL decve ase bp
decte ase upon
hen
Brady couelia- a
B7adycosolia o
B radycakclia

y called
noTma a t

con tact
Lofth
with all ehemical
all chermicals.
Avofd qgkin eye
Avofd he expeument done
elean o wash our hands

sem bl
Assem bl ee
fsolatud heat o
he past e
8he
one Uenbuce ond Jue Abua

32
OF TECHNICAL EDUCATION
MAHARASHTRA STATE BOARD
 (0813)
Pharmacol09y and TOXicology Experiment No, 8

Also Potassium ions causes,

...ssnssn.(increase/decrease) in heart rate,

2.. .*snonssss ..(increase/decrease) in force of contraction,

3....ssos *usso tos(increase/decrease) in tone.

11.0 Questions
Write answers to Q... Q........(Questions to be allotted by subjectteacher)
1. How a Calcium ion produces contraction of heart?
2. Why there is increase in heart rate and force of contraction?
3. Which type of effect is produced by .Calcium ions?
4. Which type of effect is produced by Potassium ions?
5. What will be the effect, if the dose of Calcium ions is increased7
6. What will be the effect, if the dose of Potassium ions is increased?
7. How the concentration of calcium within the cells is increased?
8. Draw the graph of effect of calcium ions on isolated heart of a frog.
9. Draw the graph of effect of Potassium ions on isolated heart of a
frog.
10. What is your interpretation from the
graph?

(Space for answers)

Wheo caulcium entu the sarco plasm binds to
Coucliac o p oni - C which moves the tro pomycen
auo ay Lem tha adion bin din 9ft thus exposfm
dnftiting ontsoction.
An n aase
sym padh tutic 3tmulatfco to the
heat intuase Contoactflth and heaut a t an
fncxeas ed in preload Aesui inan incte as
ed orce
o onbactfon by stauilings Jano e the heasd ' s
dose not St equlvë a
chahge in contrac titiy
Thy play an Im portant Leto n
slngcu tran sculatior
palioay toha hy A Cs a
second MoLSS enger
nwLotransmittr eloose TO newtong euN
and un t t lizalilen

MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION

39
 Pharmacology and Toxicology (0813)
Experiment No B
(Space foranswers)td
JOactd
he cell mumbrane pouhial by pote
ens alloos the ceU
So diu
and
pouniialsple e elecbucal Quat
.an
the abfU
csthaxg
aTion
e
sCiücal
eells to pYocuce ecbital
Docly undüer
b.cthe
Os neulohans mttey mus cle CoMta on
und
gbeh
heasct unlor

5 he amount eCcaltium ons absorbed to t h

monotn ougy An CHoases Coluum donS haue uoo n menuo
eech on the phosphati clayl cholne memb ,Name
ct Jower Conc. Cind haAccanino
sotaning eecb
ConC

t t neuwonal exdtebitti,
6 1 Potqss+um lons COun

memban nes and hgh extracelLb

clepolcui2frg
potassTUm ton entratfons Can procluce astogl
S welling.

espon se o qehemital eledbital or physfeal stlmulu

i n a eellulay
fntna cttdn toth q eeu SwaLe Heceptor
calcum Concentctfon suse ror a n ' x o extracelldu
or rom fntracellla Calcium $tores 8veh
olium O
as the endo plashe 6T 3ancoplas mlC STtcuum

40
TECHNICAL EDUCATION
ARASHTRA STATE BOARD OF
 Phamacology and Toxicology (0813)

9.0 Observation Table: Exoeriment No

Fill the observations from the observed CD.

Sr. Dose of Heart ratee

Force of contraction
No Acetyicholine (ml) (Beats/min)
Frogs ringer 30-35 Normal Tone
2 0.1 ml Normal
Frogs ringer
0.2 ml

5 Frogs ringer
0.4 ml
7 Frogs ringer
8 0.8 ml

10.0 Conclusion:
Therefore, from the observations, it is concluded that acetylcholine
causes
es,
1....**** .increase/decrease) in heart rate,
2.
...(increase/decrease) in force of contraction,
3.. (increase/decrease) in tone.

11.0 Questions
Write answers to Q... Q.... . . Q... (Questions to be allotted by subject
1. Write the mechanism of action of
teachasl
acetylcholine
2. Why there is decrease in heart rate and force of contraction ?
3. List five drugs having parasympathomimetic action.
4 Which type of effect is produced by Acetylcholine?
5 Name and write the location of muscarinic receptors in the
body.
6. Name and write the location of nicotinic receptors in the body.
7. Draw the graph (dose response) of effect of acetylcholine on the heart.
8. List five drugs having parasympathomimetic action.
9. List five drugs having parasympatholytic action.
10. What is your interpretation from the graph?

(Space for answers)

Acetylcholine procuces neqiliue chronotaophuc
negdiu Jonotrophic eet en heast ae ileholune
ateleholune
mciny ats as muscasunie nuicotfni ece ptors
eceptors

MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION 46

 v and Toxicology (0813)
P h a m a d o r O g ya n d T o x i e

Experiment No. 9

oAfng conbractU clone oimauüy bu

pechenux aucum eoreas
e o
m&intafning lowese
calc
LrO Jev els an Ahe cuto set CouLouac mqocgtu
CUn CL ctfon
dxing potentfal.
hcuingpcua sympochcuc
DuLgs
o ctfon-
3 PiLo capthe Belthan echel Methacholine
wNestofme
endro phonium
ACetylchotfhe Chie
u Chie neuotran Smittx t h e paa sUym-
p

oeuwous
a t h e t e

Suslem me pouat e utonomic nesutus3

sysemthod contodot 8mooh mustles
n ceoses diledtis Dlood
e s
vess
ell
bodiuy Secre-tfon s and sloos heudt at
M M,, MaM4, Ms he Ma eceptoas ound n
ceLebral cortex estut
Me
salfucdu glanda M
ceptoTS
Heceptors Locetd in smooth musdles
G.Nfcotnic AeceptoTS Au Jound in ihe cowdlicC tfssuves
cental neuwous
Ktum, h e pephexal systts and neswous
skeletal mus ds.
& Dugs houina
PtloP?lo catpInep Cbcaukymp auhite Action-
cuthatlechel
MeMe-tha choline
w Nesti gfme
En droho niun.

haufng Sym patholau actfon

GUdne thteine
ndoramene
od
Dexa20 S*ne
eta blockex
v PLprenelel

MAHARASHTRA STATE BOARD OF TECHNICAL

EDUCATION
47
 and Toxicology (0813) Experiment No. 10
Phamacol0gy

(Space for answers)

Oodtus
Recus abelominu mu cle e the LeS t h e vountcuuy
k e l t a l musd thect pYOcLiecs Louo e conttractfon
Hes ponse To TH duug aceych oline o
The mchansm s actfon o aceyl choine a
he chotnexgtc ds an este aceu aid cho üne
ohfch act as a newLDt san Smit hashas A Aee a
Vasoclflator agunt a Mus Casünie agonfst hogmone a
hunan
human metaboteq mLsde meteubote q neuLo tCuNS M
Acellchetine metabolls back Jnlo a celate and eh oineo
time o maximum bTain elevciio ACh and
choüne
ehoine pToduced b y A aone Jaggedl slighty behind
behind
he peak Jevel m obsesw ed e ARE
6The Le cus abdo minus mus di known as the
the
a bdo minau Muste er abs a pciud mus cle
unring Uedically en each sicu t h e a u a l
woul
woll e he hudan abdome as oel oLS ha
Some othes

8 Tonosi tet uphos phadi ve cuLonium

LO LwLDnium Suotra cusdum Vmva twiium.

MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION 53

 rmacology
and
Toxicology 313)
(0813)
Experiment No. 11

(Space for answers)

Nis(exad 9ans.

he luno euinea pfa belongs to Smoath mus clo.

Avoide
Avoid the JLse o o r e p s db taans ex the Stern becau e

damage he tissue hecunclle t

38)
A Avoid
vd d the
Ahe appuecctfon
bygeus
ex cessïve a pressuee.
i Use
Use about
about C - 3 CO pie ce e un os he
O the
ex pexmentl
pupoSe.
TtTs
Tt Co-07de'naleol Controcttoo and uelaxcdtfon
e Ctraul and Jongtudlnal oy musCls.

Spasm Tt fs 3Usai ned nUolun tay mus de

ontactfon
ontractfoo and hedu eohfch Prõcuces Spasms
a Calecl ag s pcsmo an

The
1ahe Contractue
CotoactuUe
eect o ACh ioum
s (
medioted vq muscadnfe Steceptors
on
guinea Pa
and s
compettbively and selectfvely blocked by atropine.

MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION 59

 Experimeni No 12 ogy(O813)
h e r m e c o l o g ya n d T o x i c o l o g y

Experiment No.12
Questions:

11.0 to Q.... Q.... Q.... Q.... (Questions

Write answers to be allotted by subject
teacher)
What are spasmogensr List Tve examples of spasmogens.

Write the clinical applications of spasmogens.

3 What are relaxants? List five examples of relaxants.

Write the clinical applications of relaxants
Which types of receptors are present in rabbit's intestine?
6.Why force of contraction increases after administration of Acetylcholine? Give reason.

7. Why force of contracion is normmal after administration of Acetylcholine in presence of

Atropine? Give reason.

8. Which type of movement is shown by isolated intestine of rabbit?

9. Which is the diference between frog's ringer and tyrode solution in respect of
composition?

10. Which precaution should be taken while performing this experiment?

(Space for answers)

Theduuug uohich procuces Spasm cauled ag
Spasmogens L caleel as p c sm ocPes pas mog enfea

Nceucholüne BaÄn ohlbide, HPstamine

PTOSta 2anciin hromboxane eu kodenes
-

douug o hith seleua3 he sp as m e the smooth

Ihe
elax odfon 9 meoth musdla
ms cles PrOcuclng
Relaxcun lsd calledas anti PCLL Oodres S poam
elaxa and 9pcus m oucs Atropine
Acloxna in SUccincholine pan cuon um atracrium

e c e pt0 r
AdaunerC
) P heasct eceptor

Prpha C) Beta (B)' adreno Tecepto

unXinal calium 30pvessess the voltage-

(spasmogenic heue in
calcum Awserit A thivd împortanit
depenont anuoasol
tion / relaxation)

EDUCATION
TECHNICAL
STATE BOARD OF
MAHARASHTRA
64

realme Shot on realme 7

 Pharmacology and Toxicology(0813) Experiment No 12
(Space for answers)
ekke C he opening o channels i nich Couse 4,0
Aepoladi2atfon omemboane and so neoease acto

potnual dfschaug V
and
Conttraotfon in ohele mus d
2.0

8.
ritustina mouument in he inact anfmal n c d .
h a me îs most mauked but sfmilau
act on
e s ulta obtalned COCousfng an n hibiti on
the P encluuum moverment wh a
low esuin9 onus
Tyuode ss soution is a soutien tha oughly isotD
toith 'ntostfHal uid and ed in physfologfcal
expeiments anod tfssue cutweo e S em b les ocated
sol, bu ontalns magnestum4 sUgcuc as en
ene y ource and uses bi coebonate phosphad
lactaiu
abeukex însterd ot

1o Auofd the uses e o e p s transee the ntestns

becaus e tdamagu he we hanclle t bynges

Avoid he a pplcodion e x
excessdue a i presSU

Ose quboudt Ci 3 pfece ce nuiUn

t h expesiment pUpOse

MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION

66

realme Shot on realme 7

 Phamas
Pharmacoloay and Toxicology (0816)
ExDeriment.No.13
7. Write the onset of action and duration of action of xylocaine.

8. For which purpose the surface anesthesia is used?

J e a c

9. How the duration of action of local anestheticS is increased?

10. Write the therapeutic uses of local anesthetics.

(Space for answers)
FPue buugs oca naes-thes Tq Calagoy-
Cu

)Procoan A Tetrac aine ii) oxe-thazaun lhe

3w Lidlo caine VRoplva caun

The mechanism o actton o oca cun

aesth esua
anaestheles mainy looks Nat chan nels. his cuses doc To
stc
blo ckade oInitaLen oncd propogauoo acuon pouni mur

b Preventfng the voltage clepenclerit încrease in Nqt

POL

eoncuctoance, o hich
e c oepolcsu2otion.

3 he onset oactfon, polency Cnd cuion actfon e

doca qnes-thetc qbo lwurun ed by he ag e na pka,
epil soubi bi prouun b'nlire Vas ocil aloy e along
oth s ue pH

Cornea Replex The wick e ottoO s touched on the

COne a e abbit eye abbit closes the
eyelies
fs calle positive coynea e e and eyelkes
aemaung Open han t s caled S neq atfve
CoTn ead
eex
The actfon tohfch
aecls the
proces o depolavacdfon
MAHARASHTRA STATE BOARD OF
TECHNICAL EDUCATION
2

realme Shot on realme 7

oeriment No.13 (OB13)-
p h a m a c o l o Y . a n 0I O X I C o l o g y . ( 0 8 1 3 )
xoarimeni No13

(Space for answers) oithot

pYpogotforn oan tmpuls e
cing oeuuee 13 knouon as mernbrane
J e a c l i

DLesttngpotendtla
he
ablinect
Laplcl. The
dwucdio0 e qctton
unR on set
acton
The
1 t O 14/ howLs.

AeUeue pcn and

esua Jora Topfcal
anesthia
used o
Ueh as Sunbwn 0s othex
Cus es Condibtons

stchehq
COLLLg ed
by pofson ock,
polu $Tin95, pofson Ju
mino u n s ingect biu
un Nqt and
minor udt
SUmac

poison
a
naesthetc Ps the
loca
epfd aseuble the actfo and
The more
heeus
the on set
acton o high he pouny e acton.
ena pka me onge he
duatior

Preveni p cin
outpatfert
ProcedueLs
m>nor

E)Use t ox
on the
eyeliey

yele

uzatfon
EDUCATION

TECHNICAL

B O A R D OF
STATE
MAHARASHTRA

72

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 Experimeni No 14 PhamacoOy.and1oxlcology(0813)
Experiment No 14
der and close it
gently so
that 7. When the light reflex is taken as a positive?
the
8. How the corneal reflex is checked?
m to the eye).
9. How the light reflex is checked?
by drop using 10. Write the therapeutic uses of mydriatics.
ental purpose.
dropper
(Space for answers)
k.
MAbinis he eect which ca es Intuases i
ha pen torch to the
corne a from
the Sl2-e opupr othe ey and he gert hith
causes mycbiasis called 0s Mydbintics
instillation or the drug.
scale without Ex-Epealune Helaxnaline Homo troplne
touching to the
ne
rom the effect of
the
g.
drug. Mycbuas cQus es myobuasis dhue To Contra cton
Saclial Muscle b e and elaxaluoh &ctla msle
pine 1%) bxe e iso eye cue o sympathali stímulaiero
Pupil Size (mm.)
5-6
Topical mycbetalsae used en ege examinoen To
aleco i's valizedTon Huna Qnd othex suduse deep
sorhin the et myciaLs m

4The ight elex a Aeter hat contrels the aiamatoe

ek he pupit, in uesponse to -he Tntenstt ight that a l l s
en The sUnad gcunguer cells h Uia n the back o

t.
eye ha assisting in adaptatfon o usfon so vaslous
Jves o ightnes7 dawkess.
subject teacher)

EA an aqnt that încuees aton

fhe PLpil

bhe uwlck ot cotton 1s touc hed en the Cov nex abbits

MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION 79

/8

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 hamuluny and.uotonyt0b 13

(pace for snswer

elose he e
raht Title
,0
(afer
oeueec tn1 Prior
ho dhpe bearn e g t Yo pr 2.0

on he pupll by
noung he pen tch o r Corne

he pupl noves o e NeW

lght eovnex o ye eye hen Me igh sueex 1,
3.0
Prope
Mioe
Maken as poslYue

Prope
& wfek e coton s touched on he Con Miou
abbt closeg the eyelfe t fs called a
relane
e 1 stúrma
posltfve conea) eex. Prop
Due
relax-

The shasp beam o u g h t preuicedl voh apen tre

thick
he to» ch
on the pupl by meufng pn kron let to can't

ight conca ohe eye he pup mov

4.0 Lea
4.1
o10sed cudnq cin eye exumninetlon to aloo

'sualiaalfon o Jeunc
)Useol to uat Ynlaurnaletu e .oondtons 4.2

Svch as t's and cyctbii. 5.0 Req

Used to ueduce celopleqta

MAHARASHTRA STATE BOARD OF TECHNICAL

EDUCATION
MAHARASH

reame Shot on realme 7

 Toxi (OB13)
ogyY and ToxIcology
and

16 Pha
Experiment No. 15

10.0 Questions:

ateite answers to Q... Q.... Q... Q.. (Questions to be allotted by subject teacher)
conduct of 1. What are miotics?

2. List five drugs ot Miotic category.

What is miosis?
the head 3
4. How the process of Miosis takes place?
5. Write the precautions to be taken while performing the experiment.

6. Which step is to be taken to avoid the drainage of the drug from the ocular cavity?
7. Write the difference between mydriatic and miotic drugs.
8. What is the effect of paralysis of accommodation on the focal length of eye?

9. Which another major class of drug produces miosis?

the therapeutic uses of Miotics.
ornea from 10. Write
(Space for answers) In he
a fos fs is the eect ohfch CaLseS decreage
pup fl e eye he agent ohfch caus es mfos ?s
are chleA mdotica.
9
Prlo caspfo ai) Cascba tel e c h othfo phil fodfoe
t h a l mib uCasb opeic m ochot

ohich Cases Contracttoo o the

Miosfs 1s the ekect
called miosis. eqt PhyeosHamine.

miosis due To contractioo cirulat

CauLeS
Mfotcs
o acdiol mus ctebres
musde and elaxatton stimuletion
t h e ege ue GUa sym pathate
JIULS

)Should
not h cuum e
be wauhed
should
sed d roppe PpUcation
Ptieo
ex cessiue
au Pess Uee

3 Avofd he

EDUCATION
TECHNICAL
BOARD OF
MAHARASHTRA
STATE

84

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 Pharmacology and Toxicology (0813)
Experiment No. 15

(Space for answers)

My cbuinics Mioc cuugs.
1 1Mycbinsf's i the di latiorn 1 Myosis s eX (essiue
the pupit Lons uclor Ppil
ho close the eyes One pupil bei mere dilau

8. he cilay mus cle Consbuiri making the one

thicke
Shovtenfmit oa lergth he Constafc n oscles
preven
staong clivesging ight as heatur
the he Aens o Vo
ening
the
phes CoYned anc
ee and ceadina
rmag
OpOpYofcs Can procuuco miosis

lo. ) Tt fs Causfn contractio ethe pup?l tothe

uL e h e eye
to nduce th'e dre mfo
Tt is ed PCasmp cuh omumelco
Sw Ttîsalso ALL ed op thalic sug

MAHARASHTRA STATE BOARD OF TECHNICAL

EDUCATION

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 Fnarmacology and Toxicology (0816 Experiment No 16
(Space for answers)
Cenal heUOUS Syst
stimulart c on the and 1.0
proudu a timpovay sense albtness and well
ugui Hhmoniq
bng as well a 4 l i e em
sq Is also mectull&y timulont the
Smelina spine cod stmuen 2.0
atkalotd is a
s ychan
Pferoto nn Dona pam
stychine tamines
SwCakeine v Aro phe 3.0
actiut et ec the ventanl hom
3 Grly cine's in hibito

he
spfna COrd Lohfch is the sit omotor neona
and he braun stem under noma! cirumstantes
ayine Prouiole nhibition omuscle tone that balante
thot exttetion ek musde tone that prourde by ofhe
neuro transmitix
Stychin s a neusatoxin ohich ac a aD antagonist
aycine and aciyl cho line ue ceptovs. 16 pimaxuly alah
he motoY neue ibres fn spina) tov d whtch tontrel
mus de entraction
As as the fu leg in a n acidl, it et the
soon
o dip ped
bupunin sensation that the aâd makes a p txs o9eel.
1) Used to uat many hum an cunerit ) Usee as
pestfclole.
Cocaine
Modaktnit
A me danil
4) A-to me x etine -

MAHARASHTRA STATE BOARD OF TECHNICAL

EDUCATION
92

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 oharma D Oxic (0813)
ioOO9y
y and
periment Noi17t Experiment No 1
nat is hypodynamic neart te19wens 1o1 99sqe)
3.
How the h y p o o y n a n s a e o neart is produced experimentally?

4 law of Heart?
is starlings
6. What
How digitalis is useful in congestive heart failure?
Tone
t h e effects of digitalis on cardiac output, conduction
Normal 7. velocity, automaticity and blood
pressure.

What is the effect of digitalis on electrocardiogram?

8.
What is the effeat of digitalis on the heart rate?

10.
LAlhy digoxin and calcium chloride are administered in markedly failing heart? Give
reason.

(Space for answers)

ot ort bso9 duugs uohich e sBLength Cosneu tothe
3nsminsqxe actiuiy
the hecu CUL aled oas asdlo torics.

Os ed To a t Congestive head ab CCHE)

)Used t treat h east hthm
i6 21G9
3)Recuuce uoelnq
Problems
hanes ' a n klug.
4) noLALE b lo od oro
sme s eviÐ a

enueee1
to ertt iu 8
Processing exctibrüng ha subhormal powe orrce
4Haclei aed by ittle Hecuced actiuiuy or change
sne riosi1A .Or exhibiüng ebnornm cuiy lo o Qmount o P0wee or
svel hesr
musuua con tra t o n e nup oclynamic
heay°

he is olatto heast peukused at constandt oress uoa4

spontaneeusy beaung cine able to generte physfological Ualus

G9ds Cocac output, Ventbue w& and poLoER.
Ouput pressuwe
eachier)
omeP.
Jeup utiis thad the stroke v oume e the lekt verbkle
5The Stooinq increcses clue Te the
vollume
evio
tolu Inureaseas
the dert venbiculae
iiezsd a moreorteul susto ic tontration.
monou
Steh causina
orT&

10 0AD 3TAT2 AHTHDA99-A

EDUCATIONDITAIO3 JA0M3
MAHARASHTRA STATE BOARD OF TECHNICAL
AACA981/

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 amacology and ToxicolO9y too
Experiment No 17 iacoogy

(Space for answers)

înwed or
weakened hecuc
h ecut uP me
Dataus belps an
mwudonoTe
heouoct
t h e o r e o the
ekktcient. It stren gthes he ouct
4,0
DD estore aq norma, stecy
Conctrecfon, b elps
fmproues blooel crulauer
uthm V

nd
2.0
he class to ligo x in ekkect ppeous as d o
culso Phdon OS he 3.0
Ist segmertt depvess for,
tox îcit
SHEVELe
ick Levesise check slgn cigoxin COun
CUochythmi ex cept
ncduce taly evesu
concuuced ucd ouohupthnia
seapfelly
Dfg-talis pYOcluucus an inowase o pteb Blooc o w
Cxease 'eUcuscuuex eslstance ve noci laLbor and aa
and dlecrea4
Cenkal venous pYesswxe anc h e t saT

Dfgoxin înhbiu s odiuro potassium ATPase eading t o

ocease in inbsc cellule soclum hich fo wn
inhibf
Socliuo depende Cclcium truns out po7t Ctopum
and ultimaTal esub n a n Inceas e
ba celular calclum.

4.0

MAHARASHTRA STATE BOARD OF TECHNICAL

EDUCATION 100
MAH

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