PARVOVIRUS#Murray Pg.

453-457
SONYA ESTI KHOLIFA

1. What is the smallest genus of the deoxyribonucleic acid (DNA) viruses ?

Parvoviridae

2. Mention two virus are the only Parvoviruses known to cause human disease.
B19 virus and Bocavirus

3. Which virus of Parvovirus that can cause aplastic crisis in patients with
chronic hemolytic anemia ?
B19 virus

4. Which virus of Parvovirus that can cause acute respiratory disease ?

Bocavirus

5. What are the other Parvoviruses that have not been shown to cause human
disease ?
RA-1 and fecal parvoviruses

6. What are the other Parvoviruses do not cause human disease and are preventable
with vaccination of the pet ?
Feline and canine parvoviruses

7. What is the morphology of Parvovirus ?

nonenveloped icosahedral capsid

8. What is the genome component of Parvovirus ?

linear, single-stranded DNA

9. How many serotype of B19 is known to exist ?

Only one

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10. Where are the B19 virus not replicates ?

1. fresh human bone marrow cells
2. erythroid cells from fetal liver
erythroid leukemia cells
3. mitotically active cells
4. respiratory epithelium
5.
in mitotically active cells and prefers cells of the erythroid lineage
(such as fresh human bone marrow cells, erythroid cells from fetal liver, and
erythroid leukemia cells)

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11. What is the viral receptor of B19 Virus ?

erythrocyte blood group P antigen (globoside)

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12. Mention two structural capsid protein of B19 virus?

VP1 and VP2 structural capsid proteins

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13. Where is the structural capsid proteins of B19 virus synthesized ?

in the cytoplasm

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14. What is the target cell of B19 virus ?

cytolytic for erythroid precursor cells

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15. What is the name of virus that has similar immunopathogenesis with B19 ?

1. Rubella virus
2. Ebola virus
3. Adenovirus
4. Herpesvirus
1. Rubella virus
Both are caused by immune complexes with virions, hence both cause rash and
arthralgia in adults.

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16. Where is Bocavirus replicates ?

respiratory epithelium

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17. Which one of the following best describes a physicochemical property of

parvoviruses?
1. Enveloped virus particle
2. Single-stranded DNA genome
3. Infectivity is inactivated by ether treatment
4. Virion exhibits helical symmetry
5. Virion is about the same size as herpesviruses
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18. Which one of the following statements is not true about parvovirus B19 ?

1. Capsid virus resistant to inactivation

2. Contagious period precedes symptoms
3. Virus crosses placenta and infects fetus
4. Transmitted via respiratory droplets
5. Disease usually occurs in summer and autumn
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19. Human erythroviruses and bocaviruses share the following properties except for
which one?
1. Nonenveloped virus particles
2. Difficult to culture
3. Cause anemia
4. Global distribution
5. No vaccine exists
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20. Which one of the following statements is most accurate concerning human
infections by parvovirus B19?
1. Parvovirus B19 is transmitted by sexual intercourse.
2. Patients with Parvovirus B19 infection should be treated with acyclovir.
3. Parvovirus B19 does not cause any human disease.
4. There is no vaccine for human parvovirus.
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21. Mention two stage of B19 viral disease .

The initial febrile stage is the infectious stage.
The symptomatic stage is immune mediated

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22. Which symptoms coincide with the second phase of the illness of B19 virus
infection?
1. Sore throat
2. Skin rash
3. Headache
4. Diarrhea
5. Cough
2
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23. What disease that caused by B19 virus that most common in children and
adolescents aged 4 to 15 years ?
1. Mild flulike illness
2. Erythema infectiosum
3. Aplastic crisis
4. Arthralgia and arthritis
5. Bronchiolitis

2. Erythema infectiosum

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24. What diseases that caused by B19 virus that are likely to occur in adults ?
1. Mild flulike illness
2. Erythema infectiosum
3. Aplastic crisis
4. Arthralgia and arthritis
5. Bronchiolitis
4. Arthralgia and arthritis
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25. What is route of transmission or spreading pathway for Parvovirus B19?

1. Respiratory droplets
2. Blood Transfusion
3. Transplantation
4. Sexual contact
1. Respiratory droplets and oral secretions

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26. Mention two season for the Parvovirus disease usually occurs .
late winter and spring

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27. What is route of transmission or spreading pathway for Bocavirus ?

1. Respiratory droplets
2. Blood Transfusion
3. Transplantation
4. Sexual contact

1. respiratory secretions

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28. What is the most serious complication of Parvovirus B19 infection ?

1. Mild flulike illness
2. Erythema infectiosum
3. Aplastic crisis
4. Arthralgia and arthritis
5. Bronchiolitis
3. aplastic crisis that occurs in patients with chronic hemolytic anemia (e.g.,
sickle cell anemia)

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29. What is the name of condition results from the combination of B19 depletion of
red blood cell precursors and the shortened lifespan of erythrocytes caused by the
underlying anemia ?
1. Granulocytopenia
2. Reticulocytopenia
3. Thrombocytopenia
4. Leukocytopenia
2. Reticulocytopenia
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30. What is the disease caused by B19 Virus that infect the fetus and kill
erythrocyte precursors, causing anemia, edema, hypoxia, and congestive heart
failure ?
hydrops fetalis

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31. A 10-year-old patient has a 5-day history of a flulike illness (headache,

fever, muscle pain, feels tired) and then a week later develops an intensely red
rash over the cheeks and a fainter “lacy” rash over the trunk and extremities.
What is the disease and etiologic agent ?
B19 Virus
Erythema infectiosum

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32. Which one of the following is a disease in which the role of parvovirus B19 has
not been established ?
Erythema infectiosum
2. Transient aplastic crisis
3. Hydrops fetalis
4. Fulminant hepatitis
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33. A 42-year-old man with HIV/AIDS presented with aplastic anemia. Using the
polymerase chain reaction, parvovirus B19 was detected in his serum. The patient
presumably acquired his parvovirus B19 infection from another person. The most
likely route of transmission is ?

1. By contact with respiratory secretions or droplets

2. By contact with a skin rash
3. Through sexual activity
4. Through a recent blood transfusion
1
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34. An 8-year-old child recently had erythema infectiosum. Her 33-year-old mother
subsequently developed arthralgia followed by painful arthritis with swelling in
the small joints of both hands. In addition to the apparent tropism for joints,
human parvovirus B19 is highly tropic for which cell type?
1. CD4 T lymphocytes
2. Renal tubule cells
3. Erythroid cells
4. Glial cells
5. Peyer patches
3. Erythroid cells

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35. What disease and what clinical appearance exhibited by the picture below?
Erythema infectiosum/fifth disease, “slapped-cheek” appearance

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36. What is the severe disease occurs in children younger than age 2 years caused
by Bocavirus ?
bronchiolitis with wheezing

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37. Which one is not the disease that caused by Parvovirus (B19)?

1. Mild flulike illness

2. Erythema infectiosum
3. Aplastic crisis
4. Arthropathy
5. Bronchiolitis
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38. What is the diagnostic test that very sensitive method for detecting the B19
and bocavirus genomes in clinical samples ?
1. Enzyme-linked immunosorbent assays
2. Enzyme immunoassay
3. Radioimmunoassay
4. Polymerase chain reaction test
4. polymerase chain reaction test

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39. What must we detect to distinguish the rash of B19 from that of rubella in a
pregnant woman ?
1. specific immunoglobulin (Ig)A
2. Specific immunoglobulin (Ig)E
3. specific immunoglobulin (Ig)M
4. Viral RNA
3. specific immunoglobulin (Ig)M
viral DNA

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40. Human bocavirus is a newly discovered parvovirus. It has been detected most
frequently in which type of sample?
1. Urine
2. Cord blood
3. Respiratory secretions
4. Fetal liver
5. Bone marrow

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