Name: __________________

Date: ___________________

BSN Biochemistry Exam

Total Marks:100

Section 1 (70 marks)

1. The general formula of monosaccharides is

a. CnH2nOn
b. C2nH2On
c. CnH2O2n
d. CnH2nO2n

2. Synovial fluid contains

a. Heparin
b. Hyaluronic acid
c. Chondroitin sulphate
d. Keratin sulphate

3. The general formula of polysaccharides is

a. (C6H10O5)n
b. (C6H12O5)n
c. (C6H10O6)n
d. (C6H10O6)n

4. Hexokinase has a high affinity for glucose than

a. Fructokinase
b. Galactokinase
c. Glucokinase
d. All of the above

5. Dihydroxyacetone phosphate and glyceraldehyde-3-phosphate are intercoverted by

a. Triose isomerase
b. Triose Phosphate Isomerase
c. Diphosphotriose isomerase
d. Dihydroxyacetone phosphorylase

6. The reaction succinyl COA to succinate requires

a. CDP
b. ADP
c. GDP
d. NADP+
7. . The carrier of the citric acid cycle is

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 a. Succinate
b. Fumarate
c. Malate
d. Oxaloacetate

8. The conversion of alanine to glucose is termed

a. Glycolysis
b. Oxidative decarboxylation
c. Specific dynamic action
d. Gluconeogenesis

9. Under anaerobic conditions the glycolysis one mole of glucose yields __ moles of
ATP.
a. One
b. Two
c. Eight
d. Thirty

10. During glycolysis, Fructose 1, 6 diphosphate is decomposed by the enzyme

a. Enolase a
b. Fructokinase
c. Aldolase
d. Diphosphofructophosphatose

11. Tricarboxylic acid cycle to be continuous requires the regeneration of

a. Pyruvic acid
b. oxaloacetic acid
c. α-oxoglutaric acid
d. Malic acid

12. The tissues with the highest total glycogen content are
a. Muscle and kidneys
b. Kidneys and liver
c. Liver and muscle
d. Brain and Liver

13. Gluconeogenesis is increased in the following condition

a. Diabetes insipidus
b. Diabetes Mellitus
c. Hypothyroidism
d. Liver diseases

14. Out of 24 mols of ATP formed in TCA cycle, 2 molecules of ATP can be formed at
“substrate level” by which of the following reaction?
a. Citric acid→ Isocitric acid
b. Isocitrate→ Oxaloacetate
c. Succinic acid→ Fumarate

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 d. Succinyl coA→ Succinic acid

15. Glucokinase
a. Is widely distributed and occurs in most mammalian tissues
b. Has a high km for glucose and hence is important in the phosphorylation of
glucose primarily after ingestion of a carbohydrate rich meal
c. Is widely distributed in Prokaryotes
d. None of these

16. The conversion of pyruvate to acetyl CoA and CO2

a. Is reversible
b. Involves the participation of lipoic acid
c. Depends on the coenzyme biotin
d. Occurs in the cytosol

17. Epimers of glucose is

a. Fructose
b. Galactose
c. Ribose
d. Deoxyribose

18. Human heart muscle contains

a. D-Arabinose
b. D-Ribose
c. D-Xylose
d. L-Xylose

19. Cane sugar is known as

a. Galactose
b. Sucrose
c. Fructose
d. Maltose

20. Which of the following is not reducing sugar?

a. Lactose
b. Maltose
c. Sucrose
d. Fructose

21. Invert sugar is

a. Lactose
b. Mannose
c. Fructose
d. Hydrolytic product of sucrose

22. A dissaccharide linked by α-1-4 Glycosideic linkages is

a. Lactose

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 b. Sucrose
c. Cellulose
d. Maltose

23. Hyaluronic acid is found in

a. Joints
b. Brain
c. Abdomen
d. Mouth

24. The epimers of glucose is

a. Fructose
b. Galactose
c. Ribose
d. Deoxyribose

25. N–Acetylglucosamnine is present in

a. Hyaluronic acid
b. Chondroitin sulphate
c. Heparin
d. All of these

26. Gluconeogenesis is decreased by

a. Glucagon
b. Epinephrine
c. Glucocorticoids
d. Insulin

27. Amylose is a constituent of

a. Starch
b. Cellulose
c. Glycogen
d. None of these

28. The 4 rate limiting enzymes of gluconeogenesis are

a. Glucokinase, Pyruvate carboxylase phosphoenol pyruvate carboxykinase and
glucose-6-phosphatase
b. Pyruvate carboxylase, phosphoenol pyruvate carboxykinase, fructose1,6
diphosphatase and glucose-6-phosphatase
c. Pyruvate kinase, pyruvate carboxylase, phosphoenol pyruvate carboxykinase
and glucose-6-phosphatase
d. Phospho fructokinase, pyruvate carboxylase, phosphoenol pyruvate
carboxykinase and fructose 1, 6 diphosphatase

29. For glycogenesis, Glucose should be converted to

a. Glucuronic acid
b. Pyruvic acid

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 c. UDP glucose
d. Sorbitol

30. The formation of citrate from oxaloacetate and acetyl CoA is

a. Oxidation
b. Reduction
c. Condensation
d. Hydrolysis

31. The following examples are important heteropolysaccharides except

a. Amylopectin
b. Heparin
c. Peptidoglycan
d. Hyaluronic acid

32. The standard free energy of hydrolysis of terminal phosphate group of ATP is
a. –7.3 Kcal/mol
b. –8.3 Kcal/mol
c. 10 Kcal/mol
d. +7.3 Kcal/mol

33. An uncoupler of oxidative phosphorylation such as dinitrophenol

a. Inhibits electron transport and ATP synthesis
b. Allow electron transport to proceed without ATP synthesis
c. Inhibits electron transport without impairment of ATP synthesis
d. Specially inhibits cytochrome b

34. Organisms which Obtain energy by trapping sunlight are called

a. Chemotrophs
b. Phototrophs
c. Hydrotrophs
d. All of the above

35. Which of the following statements regarding T.C.A cycle is true?

a. It is an anaerobic process
b. It occurs in cytosol
c. It contains no intermediates for Gluconeogenesis
d. It is amphibolic in nature

36. Compounds having the same structural formula but differing in spatial configuration
are known as
a. Stereoisomers
b. Anomers
c. Optical isomers
d. Epimers

37. α-D-glucose and β -D-glucose are

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 a. Stereoisomers
b. Epimers
c. Anomers
d. Keto-aldo pairs

38. α-D-glucose + 1120 → + 52.50 ← + 190 β-D-glucose for glucose above represents
a. Optical isomerism
b. Mutarotation
c. Epimerisation
d. D and L isomerism

39. In glucose the orientation of the —H and —OH groups around the carbon atom 5
adjacent to the terminal primary alcohol carbon determines
a. D or L series
b. Dextro or levorotatory
c. α and β anomers
d. Epimers

40. Isomers differing as a result of variations in configuration of the —OH and —H on

carbon atoms 2 and 4 of glucose are known as
a. Epimers
b. Anomers
c. Optical isomers
d. Steroisomers

41. The sugar found in DNA is

a. Xylose
b. Ribose
c. Deoxyribose
d. Ribulose

42. The sugar found in RNA is

a. Ribose
b. Deoxyribose
c. Ribulose
d. Erythrose

43. The constituent unit of inulin is

a. Glucose
b. Fructose
c. Mannose
d. Galactose

44. The polysaccharide used in assessing the glomerular fittration rate (GFR) is
a. Glycogen
b. Agar
c. Inulin

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 d. Hyaluronic acid

45. The glycosaminoglycan which does not contain uronic acid is

a. Dermatan sulphate
b. Chondroitin sulphate
c. Keratan sulphate
d. Heparan sulphate

46. Keratan sulphate is found in abundance In

a. Heart muscle
b. Liver
c. Adrenal cortex
d. Cornea

47. An example of a saturated fatty acid is

a. Palmitic acid
b. Oleic acid
c. Linoleic acid
d. Erucic acid

48. If the fatty acid is esterified with an alcohol of high molecular weight instead of
glycerol, the resulting compound is
a. Lipositol
b. Plasmalogen
c. Wax
d. Cephalin

49. A fatty acid which is not synthesized in the body and has to be supplied in the diet is
a. Palmitic acid
b. Lauric acid
c. Linolenic acid
d. Palmitoleic acid

50. Essential fatty acid

a. Linoleic acid
b. Linolenic acid
c. Arachidonic acid
d. All these

51. Cephalin consists of

a. Glycerol, fatty acids, phosphoric acid and choline
b. Glycerol, fatty acids, phosphoric acid and ethanolamine
c. Glycerol, fatty acids, phosphoric acid and inositol
d. Glycerol, fatty acids, phosphoric acid

52. The importance of phospholipids as constituent of cell membrane is because they

possess

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 a. Fatty acids
b. Both polar and nonpolar groups
c. Glycerol
d. Phosphoric acid

53. Deterioration of food (rancidity) is due to presence of

a. Cholesterol
b. Vitamin E
c. oxidation of lipids
d. Phenolic compounds

54. Molecular formula of cholesterol is

a. C27H45OH
b. C29H47OH
c. C29H47OH
d. C23H41OH

55. The cholesterol molecule is

a. Benzene derivative
b. Quinoline derivative
c. Steroid
d. Straight chain acid

56. Unpleasant odours and taste in a fat (rancidity) can be delayed or prevented by the
addition of
a. Lead
b. Copper
c. Tocopherol
d. Ergosterol

57. All the following have 18 carbon atoms Except

a. Linoleic acid
b. Linolenic acid
c. Arachidonic acid
d. Stearic acid

58. 144. A 20-carbon fatty acid among the following Is

a. Linoleic acid
b. α -Linolenic acid
c. β -Linolenic acid
d. Arachidonic acid

59. Lecithin contains a nitrogenous base named as

a. Ethanolamine
b. Choline
c. Inositol
d. All of these

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60. Gangliosides are the glycolipids occurring in
a. Brain
b. Liver
c. Kidney
d. Muscle

61. Arachidonic acid contains the number of double bonds:

a. 2
b. 3
c. 4
d. 5

62. Δ9 indicates a double bond between carbon atoms of the fatty acids:
a. 8 and 9
b. 9 and 10
c. 9 and 11
d. 9 and 12

63. Saponification number is

a. mg of KOH required to saponify one gm of fat or oil
b. mg of KOH required to neutralize free fatty acids of one gms of fat
c. mg of KOH required to neutralize the acetic acid obtained by saponification
of one gm of fat after it has been acetylated
d. None of these

64. Lecithins are composed of

a. Glycerol + Fatty acids + Phosphoric acid + Choline
b. Glycerol + Fatty acids + Phosphoric acid +Ethanolamine
c. Glycerol + Fatty acids + Phosphoric acid +Serine
d. Glycerol + Fatty acids + Phosphoric acid +Beaine

65. LCAT is
a. Lactose choline alamine transferse
b. Lecithin cholesterol acyl transferase
c. Lecithin carnitine acyl transferase
d. Lanoleate carbamoyl acyl transferase

66. Chylomicron, High density lipoproteins (HDL), low density lipoproteins (LDL) and very
low density lipoproteins (VLDL) all are serum lipoproteins. What is the correct
ordering of these particles from the lowest to the greatest density?
a. LDL, HDL, VLDL, Chylomicron
b. Chylomicron, VLDL, LDL, HDL
c. VLDL, HDL, LDL, Chylomicron
d. Chylomicron, LDL, VLDL, HDL

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67. A fatty acid which is not synthesized in human body and has to be supplied in the
diet is
a. Palmitic acid
b. Oleic acid
c. Linoleic acid
d. Stearic acid

68. Which of the following is not essential fatty acids?

a. Oleic acid
b. Linoleic acid
c. Arachidonic acid
d. Linolenic acid

69. When choline of lecithine is replaced by ethanolamine the product is

a. Sphingomyelin
b. Cephalin
c. Plasmalogens
d. Lysolecithine

70. The nitrogenous base in lecithin is

a. Ethanolamine
b. Choline
c. Serine
d. Betaine

Section 2-Short Essay Questions (30 marks)

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1. Describe the electron transport chain reactions, and give its importance in oxidative
phosphorylation.

2. What are the function of essential fatty acids?

3. Define Carbohydrates. Write down the biomedical importance/function of carbohydrate?

4. Differentiate between amylose and amylopectin?

5. Briefly describe types of lipoprotein?

6. Classify and write the main function of phospholipids?

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