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24/10/65 24/10/65
Mx. Mx.
- Off cefotaxime -> Meropenem (120 mg/kg/day) - On ETT No. 4 with cuff
- Lactulose 15 ml oral tid - NPO
- FFP 120 ml IV drip in 1 hr q 12 hr - Octeotide (2 mcg/kg/hr)
- LPRC 60 ml IV drip in 4 hr - Morphine (10 mcg/kg/hr)
- 5%DNSS 500 ml IV rate 45 ml/hr - ปรับ LPRC เปOน IV drip in 1 hr
- Observe neurological sign
แจWงอาการและ prognosis ใหWญาติรับทราบ
- Octeotide (1 mcg/kg/dose) IV load in 15 mins then
ญาติขอปฏิเสธ CPR, การใหWยากระตุWนความดันโลหิต
Octeotide (1 mcg/kg/hr)
ไมJเจาะเลือดตรวจเพิ่มเติม
- Tranexamic acid (10 mg/kg/dose) IV q 6 hr
23/10/65 24/10/65 25/10/65 26/10/65 27/10/65 28/10/65 29/10/65
FFP, LPRC
Lactulose
Omeprazole Octeotide
Cefotaxime (150MKDay) Metronidazole (15 MKDay)
Meropenem (120 MKDay)
23/11/65 24/11/65
Mx. Mx.
- 0.9%NSS 160 ml IV drip in 1 hr then 5%DN/2 500 ml - retain foley catheter
IV drip rate 90 ml/hr (MT+7% def-load) - Work up lab เพิ่มเติม ไดWแกJ LFT, Triglyceride,
- Record I/O, keep urine output > 125 ml/8 hr Cholesterol, UA, urine protein, urine Cr
- วาง cold pack กระตุWน void - 5%DN/2 500 ml IV drip rate 90 ml/hr (MT+7%
- 03.00 น. Void ออกเพิ่ม 1 ml/kg/hr (in 3 hr) def - load) -> (15.00 น.) IV rate 85 ml/hr
(MT+5%def)
Investigation (24/11/65)
Liver function test Urinalysis
Total bilirubin Color, Transparency Yellow, clear
Direct bilirubin Specific gravity 1.015
Albumin 2.83 pH 6.0
Globulin 1.49 Leukocyte Negative
AST 45 Protein Negative
ALT 16 Glucose 4+
ALP 72 Ketone Negative
Erythrocyte (Blood) 4+ (trauma)
RBC 1-2
Triglyceride 237
WBC 0-1
Cholesterol 105
Epithelium cells 0-1
ผูÄปäวยเสียชีวิต
25/11/65 เวลา 03.40 น.
No autopsy
Ceftazidime
Ceftriaxone Amikacin
PICC line
LPRC LPRC
LPPC
Consult
palliative
Progression 16/10/65 Complete blood count
Hb (g/dL) 9.5
Hct (%) 27.9
MCV 77.6
• V/S: BT 38.2oC, PR 120/min, RR 24/min, BP 113/80 mmHg, WBC (cell/mm3) 2,390
SpO2 97% ANC 2,007
• PE: Alert, tender at both mandible, no swelling Neutrophil (%) 84%
Lymphocyte (%) 10%
• Management: Monocyte (%) 6%
• Consult ทันตกรรม ประเมินเรื่อง dental root abscess -> Eosinophil (%) 0%
ไม'พบ source of infection Platelets 34,400
• Empiric antibiotics: ceftriaxone (cell/mm3)
Nasopharyngeal swab
RSV Negative
Progression 19/10/65
Complete blood count
Hb (g/dL) 8.6
• V/S: BT 39.6oC, PR 120/min, RR 26/min, BP 118/70 mmHg, Hct (%) 25.8
SpO2 98% MCV 79
• PE: puffy eyelids, no crepitation, liver just palpated WBC (cell/mm3) 3,025
ANC 1,506
• Intake 3175 ml/ output 2500 ml (positive 6725 ml) Neutrophil (%) 67%
• Management: Lymphocyte (%) 18%
• Step antibiotics: ceftazidime, amikacin Monocyte (%) 12%
• Furosemide 20 mg IV Atypical lymphocyte(%) 1%
Myelocyte (%) 2%
Platelets (cell/mm3) 34,400
22/10/65 23/10/65 24/10/65 25/10/65 26/10/65 27/10/65 28/10/65
Progression CT brain
Ceftazidime
Amikacin
PICC line
LPRC LPRC LPPC
Progression 24/10/65
มีปzญหา abdominal pain with bilious
vomiting
PE: V/S: BT 37.2oC, PR 120/min, RR
28/min, BP 101/75 mmHg
Abdomen: no distention, generalized
tender, no guarding, no rebound
Management:
- NPO
- 5%DNSS 500 ml IV 130 ml/hr.
- Ondansetron 6 mg IV
- Omeprazole 40 mg IV q 12 hr.
CT brain 28/10/65
CT brain 28/10/65
CT brain 28/10/65
Progression
Hypervolemic hyponatremia
• Management: restrict fluid
Progression
Ceftazidime
Amikacin
Dexamethasone 4 mg IV q 6 hr
PICC line
LPPC
5/11/65 6/11/65 7/11/65 8/11/65 9/11/65 10/11/65 11/11/65
Progression
ผูÄปäวยเสียชีวิต
8/11/65 เวลา 14.16 น.
No autopsy
PICC line
Cause of death
• Ewing sarcoma/PNET
Point of learning
Ewing sarcoma/PNET
• Clinical manifestation
• Pain, swelling, limitation of motion, and tenderness over the involved bone or soft tissue
• Patients with huge chest wall primary tumors may present with respiratory distress
• Patients with paraspinal or vertebral primary tumors may present with symptoms of cord
compression
• Often associated with systemic manifestations
• Diagnosis
• A large, associated soft tissue mass often is visualized on MRI or CT
• Evaluation for metastatic disease includes CT of the chest, radionuclide bone scan or PET
scan, and bone marrow aspiration and biopsy
Point of learning
Ewing sarcoma/PNET
• Immunohistochemical staining
• Small, round, blue cell tumors
• Treatment
• Best managed with a comprehensive multidisciplinary approach in which the surgeon,
chemotherapist, and radiation oncologist plan therapy
• Prognosis
• Nonmetastatic, distally located extremity tumors: cure rate of up to 75%
• Metastatic disease: poor prognosis, with <30% surviving long term
Point of learning
Increase intracranial pressure
• Brain edema
• Vasogenic edema
• Cytotoxic edema
• Interstitial edema