Republic of the Philippines

Department of Education
Region V – Bicol
Schools Division Office
Camarines Norte
Eco Athletic Field, F. Pimentel Ave., camarines.norte@deped.gov.ph (054) 440-1772/(054) 440-4464
Daet, Camarines Norte DepEd Camarines Norte

CODE S10LT-IIIe-38

GRADES 1 to School Labo Science and Technology H.S. Grade Level 10 Quarter 3
12 DAILY Teacher Pierre S. Lalaqui Learning Area SCIENCE 10
LESSON PLAN Teaching Date and Time April 17-18, 2023 7:30-8:30/2:00-3:00/ 3:00-4:00

The learners demonstrate an understanding of:

1. the information stored in DNA as being used to make proteins;
A. Content Standards
2. how changes in a DNA molecule may cause changes in its product; and
3. mutations that occur in sex cells as being heritable.
The learner shall be able to write an essay on the importance of adaptation as a
B. Performance Standards
I. OBJECTIVES

mechanism for the survival of a species.

Explain how mutations may cause changes in the structure and function of a protein.
S10LT-IIIe-38

C. Learning Competencies/ At the end of the lesson the students should be able to:
Objectives a. define chromosomal mutation;
b. explain chromosomal mutations and their causes;
c. identify different types of genetic disorders; and
d. create an illustration of chromosomal mutations.
HEREDITY: INHERITANCE AND VARIATION
II. CONTENT (Subject Matter/Lesson)
Chromosome Mutations
1. Teacher’s Guide pages
A. REFERENCES
III. LEARNING
RESOURCES

2. Learner’s Materials pages Page 209-213

3. Textbook pages
4. Additional Materials from
Google Images, PowerPoint Presentation, Manila Paper, and Pen touch
Learning Resource portal
B. Other Learning Resources https://youtu.be/vl6Vlf2thvl (Mutations by Amoeba Sisters)
The teacher will administer the recapitulation using the paper ball game using these
questions.

1. What might happen to the DNA sequence after having a mistake in replicating
I. ELICIT
itself?
2. In what process do changes in DNA sequence occur?
3. Will this cause changes in the genes?
4. What do you call these changes?
IV. PROCEDURES

GUESS WHO
The students will identify and guess if who is/are in the picture.

II. ENGAGE

CYCLOPS MARVELS SUPER HERO

“SDO Camarines Norte: Facilitating Dreams…, Valuing Aspirations…”

 Republic of the Philippines
Department of Education
Region V – Bicol
Schools Division Office
Camarines Norte
Eco Athletic Field, F. Pimentel Ave., camarines.norte@deped.gov.ph (054) 440-1772/(054) 440-4464
Daet, Camarines Norte DepEd Camarines Norte

How can you describe Cyclops? What do they have in common?

Leonardo, Raphael, Donatello and Michelangelo of teenage mutant ninja turtles.

Are they real? Do they really exist?

Do you know its story? How do they become mutant ninja turtle?

The students will perform the activity in the learner materials. Page 284-287 of
Grade 10 Science LM.

In this activity the students are expected to illustrate and differentiate the kinds of
chromosomal mutations.

TRANSLOCATION
Procedure:
1. Using modeling clay, make models of two (2) chromosomes. One should have a
different color and size from the other.
2. Break one part of each of the chromosomes. Exchange the parts and attach them
to each of the other chromosomes.

DELETION
Procedure:
1. Make a model of two (2) chromatid (one of the duplicated copies of a
chromosome).
2. When done, in your second model, remove a portion of it (close to either end of
III. EXPLORE
the chromosome or within the long arm or short arm). If you choose to remove a
part within the arms, be sure to join back the bottom part.

INVERSION
Procedure:
1. Make two (2) colored chromatids.
2. In the second chromatid, break a portion (with two colors) of it.
3. Reinsert it to the chromatid in reverse manner.

Guide Questions:

Q1. How are the three chromosomal aberrations different from each other? How are
they similar?
Q2. Do you think the normal genetic content of the chromosome is affected?
Q3. Which condition results to gain of chromosome material? Loss of chromosome
material?
Q4. What are some possible effects of these chromosomal mutations?
Q5. What are the positive effects of mutations?

“SDO Camarines Norte: Facilitating Dreams…, Valuing Aspirations…”

 Republic of the Philippines
Department of Education
Region V – Bicol
Schools Division Office
Camarines Norte
Eco Athletic Field, F. Pimentel Ave., camarines.norte@deped.gov.ph (054) 440-1772/(054) 440-4464
Daet, Camarines Norte DepEd Camarines Norte

The teacher will choose 3 groups to present their work in the class. Then the teacher
will check and analyze the group outputs.

IV. EXPLAIN

The teacher will discuss the different effects of chromosome

mutations which can lead to variety of genetic disorders.

Genetic disorders

1. Recessive disorders
A child receives two defective genes from each parent. The carrier does not express
the disorder because it is not detectable by the dominant normal gene, it can pass
the defective gene to their children.
a. Sickle Cell Anemia – inherits two defective genes will have abnormally shaped
red blood cells and may die at an early stage.
b. Tay-Sachs disease – lack of an important chemical in the brain.
c. Phenylketonuria – can cause serious mental retardation in infants.
d. Cystic fibrosis – a disease in which some glands produce too much mucus that
clogs and damages the lungs.

2. Sex-linked Disorders
V. ELABORATE
Sex-linked disorders are more common in men because they have only one X
chromosome, so all defective genes on the chromosome will be expressed.

Shows picture of example of human genetic syndrome and students will try to
describe the appearance of each individual in the picture.

3.Human Genetic Syndrome – genetic disorders that may have few or too many
chromosomes.
a. Cri du chat – deletion of part of the short arm of chromosomes 5.
b.Down syndrome – (trisomy 21) is known as mongolism. A child receives extra
chromosomes (chromosome 21) and has a distinctive physical appearance.
c. Edward syndrome – (trisomy 18) happens when there is an extra number 18
chromosome.
d. Patau’s syndrome – (trisomy 13) caused by an extra copy of the number 13
chromosome.
e. Klinefelter’s syndrome – (XXY) a male who have this syndrome has two or more
X-chromosomes in addition to their Y-chromosomes.

“SDO Camarines Norte: Facilitating Dreams…, Valuing Aspirations…”

 Republic of the Philippines
Department of Education
Region V – Bicol
Schools Division Office
Camarines Norte
Eco Athletic Field, F. Pimentel Ave., camarines.norte@deped.gov.ph (054) 440-1772/(054) 440-4464
Daet, Camarines Norte DepEd Camarines Norte

f. Turner’s syndrome – has 45 chromosomes.

I. Identify what genetic disorders are being stated.
1. Deletion of part of the short arm of chromosome 5.
2. Has an extra chromosome 21.
3. Has 45 chromosomes.
4. It is caused by an extra copy of chromosome 13.
5. There is an extra number 18 chromosome.

II. Identify the type of chromosome mutation.

1. A portion of the chromosome is missing or deleted. Known disorders in
humans such as Cri du chat.
VI. EVALUATE
2. In one type of Down syndrome, one chromosome breaks off and attaches
to another chromosome.
3. When a portion of one chromosome is transferred to another chromosome.
Sometimes, parts of different chromosomes switch places (reciprocal
exchange).
4. A portion of the chromosome has broken off, turned upside down and
reattached, therefore the genetic material is backward.
5. Jacobsen syndrome is a disorder caused by this type of mutation. This is
a very rare disorder. Those affected have normal intelligence or mild
mental retardation, with poor or excessive language skills.

VlI. EXTEND Watch the link provided and answer the questions provided below. (Use your
notebook in answering the questions)
https://youtu.be/vl6Vlf2thvl (Mutations by Amoeba Sisters)
1. What can you say about the video?
2. How this video contributes to your knowledge about mutation?
3. Why it is important to study mutation?

“SDO Camarines Norte: Facilitating Dreams…, Valuing Aspirations…”