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Q.3 What is the diff erence between the skeletal, cardiac, and smooth muscles?
The difference between skeletal, cardiac, and smooth muscles is shown in the table.
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Skeletal muscle is supplied by somatic nerves. Cardiac and smooth muscles are supplied by
autonomic nerve fibers.
Myofibrils are the thin parallel filaments present in the sarcoplasm of the muscle fiber.
The structural and functional unit of skeletal muscle is known as sarcomere. It extends
between two ‘Z’ lines.
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A muscle cell consists of alternate transverse dark (anisotropic) A-band, and light (isotropic) I-
band. A-band has in its center a region of low refractive index (H-band or Hensen line), and I-
band a line of high refractive index (Z-line or Dobie line).
‘A’ band is the dark band present in the myofibrils of the muscle. It is anisotropic to polarized
light; i.e., if polarized light is passed through this area of the muscle, the light rays are refracted
in different directions. So this band is called ‘A’ band.
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‘I’ band is the light band present in the myofibrils of the muscle. It is isotropic to polarized light,
i.e. when polarized light is passed through this area of the muscle, all the light rays are
refracted at the same angle. So this band is called ‘I’ band.
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Myofilaments are the thread-like protein filaments present in the sarcomere. Myofilaments are
of two types, actin filaments and myosin filaments.
Actin filaments.
Actin filaments are thin filaments with a diameter of 20 Å and extend from either side of the ‘Z’
lines, run across the ‘I’ band, and enter into the ‘A’ band up to the ‘H’ zone. Myosin filaments
are thick filaments with a diameter of 115 Å and are situated in the center of the ‘A’ band.
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The actin filament consists of three types of proteins called actin, tropomyosin, and troponin.
The myosin filament consists of myosin molecules.
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The contractile elements of the skeletal muscle are the muscle proteins namely myosin, actin,
tropomyosin and troponin.
‘H’ zone is a light area in the middle of the ‘A’ band. ‘M’ band is the middle part of myosin
filaments situated in the middle of the ‘H’ zone.
The ‘T’ tubules are responsible for the rapid transmission of the action potential through the
muscle fiber. The “L” tubules store a large quantity of calcium ions.
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The properties of skeletal muscle are excitability, contractility, and muscle tone.
The response of the living tissue to a stimulus in the form of physicochemical change is known
as excitability.
Conduction of nerve signal by depolarization which changes the normal resting negative
potential to positive potential followed by repolarization back to the normal negative
membrane potential is called Action Potential.
Stimulus is an agent or influence that brings about the response in an excitable tissue.
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Intensity or strength
Duration.
The strength-duration curve is the curve that demonstrates the relationship between the
strength and the duration of the stimulus. It is also known as the excitability curve.
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Rheobase is the minimum strength of the stimulus that is required to excite the tissue.
Utilization time is the minimum time required to excite the tissue when a stimulus with
rheobasic strength (threshold strength of stimulus) is applied.
Chronaxie is the minimum time required to excite the tissue when a stimulus with double the
rheobasic strength is applied.
Chronaxie helps to determine the excitability of the tissue. Longer the chronaxie, the lesser is
the excitability.
Paralysis of muscles
Neural diseases.
Isotonic contraction
Isometric contraction.
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Isotonic contraction is the type of contraction in which the tension remains the same and
change occurs only in the length of the muscle fibers. An example is the contraction of the
biceps muscle during simple flexion of the arm.
Isometric contraction is the type of contraction in which the length of the muscle fibers
remains the same and change occurs only in the tension. An example is the contraction of arm
muscles while pulling any heavy object.
It is the load that the muscle must generate to overcome the higher pressure.
Q.36 What are the diff erent periods in a simple muscle twitch?
Q.37 Give the normal duration of diff erent periods of a simple muscle twitch.
Q.38 Why is the contraction period shorter than the relaxation period?
The contraction period is shorter than the relaxation period because the contraction is an
active process and relaxation is a passive process.
The latent period is defined as the time interval between the point of stimulus and point of
contraction.
It is the time taken for the impulse to travel along the nerve from the place of
stimulation to the muscle
It is the time taken for the initiation of chemical changes
It is the delay in the conduction of impulse at the neuromuscular junction
It is the time taken for the release of neurotransmitter at the neuromuscular
junction
It is the time taken to overcome the viscosity of the muscle
It is the time taken to overcome the inertia of the instruments in experimental
conditions.
Cold conditions
During the onset of fatigue
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Q.43 Classify the skeletal muscles depending upon the contraction time. Give
examples.
Slow or red muscles, which have longer contraction time. Examples: back muscles
Fast or pale muscles that have shorter contraction time. Examples: hand muscles and ocular
muscles.
Q.44 What are the diff erences between red and white muscle fibers?
Myoglobin content is high. So. it is red Myoglobin content is less. So, it is pale
Blood vessels are more extensive Blood vessels are less extensive
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Response is slow with long latent period Response is rapid with short latent
period
Depends upon cellular respiration for Depends upon glycolysis for ATP
ATP production production
Q.45 What are the factors aff ecting the force of contraction of the muscle within
physiological limits?
Subminimal stimulus
Minimal stimulus
Submaximal stimulus
Maximal stimulus
Supramaximal stimulus.
Threshold or minimal stimulus is the stimulus with minimum strength required to cause
minimum response in the tissues.
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Q.48 What are the eff ects of two successive stimuli on muscle?
Beneficial effect
Superposition
Summation.
When two stimuli are applied to a muscle one after another in such a way that the second
stimulus falls after the relaxation period of the first twitch, two separate contractions are
recorded and the force of the second contraction is greater than that of the first contraction.
This is known as a beneficial effect.
An increase in the temperature during the first contraction decreases the viscosity of muscle.
So, the force of the second contraction is more.
While applying two successive stimuli, if the second stimulus falls during relaxation of the first
twitch, the first curve is superimposed by the second curve. This is called superposition or
incomplete summation.
When two stimuli are applied one after another and if the second stimulus falls during the
contraction period or second half of the latent period, two contractions are summed up, giving
a single contraction which is bigger and broader than a simple muscle curve. This is known as
summation or complete summation.
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The decrease in the response of the muscle due to repeated stimuli is known as fatigue.
Exhaustion of acetylcholine
Accumulation of metabolites like lactic acid and carbon dioxide
Lack of nutrients like glycogen
Lack of oxygen
Q.55 Mention the order of site (seat) of fatigue in the intact body.
Q.56 How to prove that the neuromuscular junction is the first site of fatigue in the
frog’s muscle nerve preparation?
In the isolated muscle nerve preparation, the nerve is stimulated continuously and the curves
are recorded till the fatigue occurs, i.e. till the muscle fails to respond to the stimulus. Then,
immediately the muscle is stimulated directly. A response is noticed in the form of a curve. This
shows that the muscle is not yet fatigued. The nerve cannot be fatigued. So, the site where
fatigue must have occurred is the neuromuscular junction.
Removal of metabolites
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When the frequency of stimuli is not sufficient to cause tetanus, the fusion of contraction is not
complete. This is known as clonus or incomplete tetanus.
Frog muscle:
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clonus = 55/sec
Pathological tetanus is a disease caused by bacillus Clostridium tetani. It affects the nervous
system and its common features are muscle spasm and paralysis.
Q.63 What is the eff ect of a moderate increase in temperature on the muscle? What
are the causes of the eff ect?
Moderate increase in temperature to about 30 to 40° C, increases the force of contraction and
decreases all the periods, i.e. the activity is accelerated.
Causes:
• Increase in excitability of the muscle
• Acceleration of chemical processes
• Decrease in the viscosity of the muscle.
Q.64 What is the eff ect of a decrease in temperature on the muscle? What are the
causes of the eff ect?
Decrease in temperature to about 10° C, reduces the force of contraction and increases all the
periods, i.e. the activity is slowed down
Causes:
Q.65 What is the eff ect of very high temperature on the muscle?
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Stiffening and shortening of the muscle fibers because of high temperature is called heat rigor.
It is due to the coagulation of muscle proteins.
Stiffening and shortening of the muscle fibers due to extreme cold is called cold rigor and it is
reversible.
Cause:
After death, there is loss of ATP. Relaxation cannot occur because of lack of ATP and that is the
cause of rigor mortis.
Freeload or fore load is the load that acts on the muscle freely even before the onset of the
contraction of the muscle.
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Q.72 State whether the muscle works better in after loaded condition or in free
loaded condition. Why?
Muscle works better in free loaded condition than in the after loaded condition. Because, in
free loaded condition the initial length of the muscle fibers increases even before the onset of
muscular contraction. And according to Frank Starling’s law, the force of contraction of the
muscle is directly proportional to the initial length of the muscle fiber within physiological
limits.
Optimum load is the load at which the work done by the muscle is maximum.
The refractory period is the period at which the muscle does not show any response to a
stimulus.
Absolute refractory period—the period during which the muscle does not show any response
at all, whatever may be the strength of the stimulus
Relative refractory period—the period during which the muscle shows some response if the
strength of stimulus is increased to maximum.
Q.76 What is the duration of absolute and relative refractory periods in skeletal
muscle?
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The absolute refractory period extends for 0.005 sec, i.e. during the first half of the latent
period. The relative refractory period extends for 0.005 sec, i.e. during the second half of the
latent period. Thus, the duration of the refractory period in skeletal muscle is 0.01 sec.
Q.77 What is the duration of absolute and relative refractory periods in cardiac
muscle?
The absolute refractory period is 0.27 sec, i.e. it extends throughout the contraction period.
The relative refractory period is 0.25 sec, i.e. it extends during the first half of the relaxation
period. Thus, totally the refractory period in cardiac muscle extends for about 0.52 sec. It is
very long compared to that of skeletal muscle.
Q.78 What is the significance of the long refractory period in cardiac muscle?
Because of the long refractory period, fatigue, tetanus, and complete summation cannot be
produced in cardiac muscle.
The muscle fibers always maintain a state of slight contraction with a certain degree of vigor
and tension. This is known as muscle tone or tonus.
Skeletal muscle: Maintenance of tone is neurogenic and it is under the influence of the gamma
motor neuron system.
Cardiac muscle: Maintenance of tone is purely myogenic and it is by the muscle itself.
Electrical changes
Physical changes
Histological changes
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Chemical changes
Thermal changes.
The potential difference between inside and outside of the cell across the cell membrane under
resting conditions is known as RMP. It is negative inside and positive outside.
Q.83 What are the mechanisms involved in the ionic basis of RMP?
Series of electrical changes taking place in the cell when stimulated is known as an action
potential.
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Action potential:
Is propagative
Is biphasic
Obeys all or non-law
Summation is not possible
Shows refractory period.
Depolarization
Repolarization.
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When stimulated, the resting membrane potential is lost in the cell. The Interior of the cell
becomes positive (up to +55 mV) and the exterior becomes negative. This is known as
depolarization.
Depolarization is due to the opening of sodium channels and the rush of sodium ions into the
cell.
The restoration of negativity inside the cell and positivity outside is known as repolarization.
Repolarization is due to the opening of potassium channels and the efflux of potassium ions
from inside to outside the cell.
When the cell is stimulated, depolarization starts slowly. After the initial slow depolarization up
to – 15 mV, the rate of depolarization increases suddenly. The point at which the rate of
depolarization increases is known as the firing level.
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During an action potential, the rapid depolarization and rapid repolarization are together called
spike potential.
After rapid repolarization, slow repolarization takes place and this is known as after
depolarization or negative after potential. It is due to a decrease in the rate of potassium efflux.
When repolarization occurs, it does not stop at the level of resting membrane potential but
goes beyond that level causing more negativity inside the cell. This is known as
afterhyperpolarization or positive after potential.
Unlike sodium channels, the potassium channels remain open for a longer duration allowing a
large number of potassium ions to move out of the cell. So, the interior of the cell becomes
more negative than the resting level.
Stimulation of the receptors, synapse, or neuromuscular junction produces some mild change
(mild depolarization) in the membrane potential. It loses its intensity as it starts spreading. This
potential change is called graded potential.
Graded potential:
Is non-propagative
Is monophasic
Does not obey all or non-law
Summation is possible
Has no refractory period.
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Patch-clamp technique is the method to measure the ionic currents across the biological
membranes.
When muscle is stimulated, action potential develops leading to the development of excitation-
contraction coupling and formation of actomyosin complex. This makes the actin filaments to
slide over the myosin filaments leading to the contraction of the muscle.
The process involved in between the excitation and the contraction of the muscle is known as
excitation-contraction coupling. Calcium is responsible for it.
Q.102 What is Ratchet theory? What are the other names for it?
Ratchet theory explains the mechanism involved in the sliding of actin filaments over the
myosin filaments during the muscular contraction. The other names for it are sliding theory
and walk along theory.
Tilting of the head of myosin towards the arm and dragging the active filament along with it is
called power stroke.
Q.104 What are the changes taking place in the sarcomere during contraction of
muscle?
The length of ‘A’ band, actin filaments, and myosin filaments remains the same.
After contraction, the calcium ions are actively pumped back into the sarcotubular reticulum
from the sarcoplasm. Decreased calcium content in sarcoplasm leads to detachment of calcium
ions from troponin. This causes the release of myosin from actin and the relaxation of muscle
occurs.
Q.106 What are the chemical changes taking place during muscular contraction?
The energy for muscular contraction is obtained by the breakdown of adenosine triphosphate
(ATP) and resynthesis of ATP from creatine phosphate and glycolytic pathway.
The breakdown of glycogen into pyruvic acid is called the glycolytic pathway or Embden–
Meyerhof pathway. Two molecules of ATP are formed in this pathway.
Q.109 Amongst the aerobic glycolysis and anaerobic glycolysis, which one is better
and why?
Aerobic glycolysis is better because a greater amount of energy is liberated during this process.
Q.110 How many molecules of ATP are formed during carbohydrate metabolism?
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38 molecules of ATP are formed during carbohydrate metabolism, i.e. during break down of
each glycogen molecule. 2 molecules are formed during glycolysis and 2 molecules are formed
during the Krebs cycle. The remaining 34 molecules of ATP are formed by the utilization of
hydrogen atoms which are released during the Krebs cycle.
In resting condition, the reaction is alkaline with a pH of 7.3. During the onset of contraction,
the muscle becomes acidic due to breakdown of ATP. During the later part of contraction, the
muscle becomes alkaline due to the resynthesis of ATP from creatine phosphate. And at the
end of contraction, once again it becomes acidic due to the formation of pyruvic acid and lactic
acid.
Q.112 What are the diff erent stages of heat production during muscular contraction?
Resting heat
Initial heat
Recovery heat.
The junction between the motor nerve ending and muscle fiber is known as the neuromuscular
junction.
Q.115 What are the important structures present in the axon terminal?
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Acetylcholine
Q.117 What is the eff ect of Ca-ions and Mg-ions on the release of acetylcholine from
motor nerve terminals?
Ca-ions serve to stimulate the release of acetylcholine while Mg-ions inhibit this release.
Q.119 Name the important events taking place during neuromuscular transmission.
Release of acetylcholine.
Action of acetylcholine
Development of endplate potential
Destruction of acetylcholine.
The change in electrical potential in neuromuscular junction is called end plate potential. It is a
slight depolarization up to – 60 mV.
Q.121 What are the diff erences between endplate potential and action potential?
It is nonpropagative
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It is monophasic
It does not obey all or none-law.
The significance of endplate potential is that it causes the development of action potential in
the muscle fiber.
When a small quantum of acetylcholine is released from the synaptic vesicle, it produces a
weak endplate potential up to – 0.5 mV. This is called miniature endplate potential.
Q.125 Name some drugs, which can stimulate the neuromuscular junction.
The single motor neuron with its axon terminals and the muscle fibers innervated by it are
together called motor units.
During muscular exercise oxygen demand increases, but muscle can keep on contracting
anaerobically. The amount of oxygen required for muscle recovery after this is called the
‘oxygen debt’.
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Smooth muscles are the nonstriated involuntary muscles, which form the contractile elements
of various organs in the body.
Actin, myosin, and tropomyosin. Troponin or troponin like substance is absent in smooth
muscles.
Q.131 Name the substance that initiates the contraction of smooth muscles.
Q.132 What are the diff erences between the electrical activity of smooth muscle and
skeletal muscle?
Tonus or tone is a state of partial contraction maintained by the smooth muscles of some
visceral organs. It is due to the tonic contraction of the smooth muscle without action potential.
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Q.134 What is the diff erence between the nerve supply of smooth muscles and
skeletal muscles?
Smooth muscles are supplied by autonomic nerve fibers (sympathetic and parasympathetic
fibers) whereas the skeletal muscles are supplied by somatic nerve fibers.
An electromyogram (EMG) is the record of the electrical activity of the muscle. It is useful in the
diagnosis of neuromuscular diseases.
Muscular cramps are involuntary, localized painful contractions of muscles often relieved by
stretching the affected muscles.
Muscular fasciculation is the spontaneous contraction of motor units, which is visible through
the skin as fine ripping movement in the relaxed muscles.
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Myasthenia gravis is an autoimmune disease in which the body develops antibodies against its
own acetylcholine receptors. The antibodies destroy the acetylcholine receptors. So even if the
acetylcholine is released, it cannot act because of the destruction of the receptors. So the
neuromuscular transmission is affected leading to weakness of the muscles.
The maximum force that can be developed during contraction is known as the strength of the
muscle.
The amount of work done by the muscle in the given unit of time is called the power of the
muscle.
The capacity of the muscle to withstand the power produced during activity is known as
endurance.
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